<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01378

Description Cyclin-dependent kinase 19 (Fragment)
SequenceLQLLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIENFKCSLLPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPAAPTKDKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTSDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQNQHQQQTAPQQQPQAAPQQPQPQQQNSTQTNGTAGGAGAGGGGAGAGLQHSQDSSLNQVPPNKKPRIGPSGANSGGPVMPSDYQHSSSRLSYQSNIQGSSQSQSTMGYSTSSQQSSQYHQSHQSHRY
Length437
PositionKinase
OrganismAptenodytes forsteri (Emperor penguin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Sphenisciformes> Spheniscidae> Aptenodytes.
Aromaticity0.08
Grand average of hydropathy-0.747
Instability index61.68
Isoelectric point8.90
Molecular weight49587.41
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01378
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.86|      31|      32|     331|     361|       1
---------------------------------------------------------------------------
  312-  330 (34.97/12.17)	QHQQQTAPQQQ..PQAAP..............QQP
  331-  361 (56.60/23.35)	QPQQQNSTQTN..GTAGGAGAGGGGA..GAGLQHS
  362-  396 (48.29/19.05)	QDSSLNQVPPNkkPRIGPSGANSGGPvmPSDYQHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      32|      85|      99|       2
---------------------------------------------------------------------------
   85-   99 (26.77/17.91)	DLKPANILVMGEGPE
  120-  134 (28.67/19.65)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01378 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TKRITSEQALQDPYFQEDPLPTSDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQNQHQQQTAPQQQPQAAPQQPQPQQQNSTQTNGTAGGAGAGGGGAGAGLQHSQDSSLNQVPPNKKPRIGPSGANSGGPVMPSDYQHSSSRLSYQSNIQGSSQSQSTMGYSTSSQQSSQYHQSHQSHRY
256
437










Molecular Recognition Features






MoRF SequenceStartStop




1) GPVMPS
2) LNQVPPNKKPRIGPS
3) QSTMGYSTSSQQSSQYHQSHQSHRY
4) SSRLSYQSNIQGS
386
366
413
397
391
380
437
409