<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01369

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceGAVTAAASPGYRLSTLIDFLLHRTYAELTVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYSCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQLTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYHFLSVSYAEGDDSPATALLLQQFKPNIEELVLDTKSGKQMKSGVKRKLSGDPCSIEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRMELSNMDIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPNHLNVFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRAGECTIFAAVRDLMVNLTLPPGGRP
Length1420
PositionTail
OrganismAptenodytes forsteri (Emperor penguin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Sphenisciformes> Spheniscidae> Aptenodytes.
Aromaticity0.07
Grand average of hydropathy-0.185
Instability index53.26
Isoelectric point8.86
Molecular weight157677.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01369
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     140.23|      29|      57|    1027|    1055|       1
---------------------------------------------------------------------------
  991- 1018 (29.99/ 9.83)	........P.PTSYHNtvT..PSPS..MMHTqSPGNLHAAS
 1019- 1052 (47.66/19.98)	SPSgalraPSPASFGP..T..PSPS..SLGI.TMGQTANFA
 1085- 1110 (28.03/ 8.70)	........PSPAARMP..G..MSPAnpSLHS.PVPD.ASH.
 1111- 1138 (34.56/12.45)	SPR....aGTSSQAMP..TsmPPPR..KL.....PQRSWAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     611.09|     190|     508|     111|     347|       3
---------------------------------------------------------------------------
   14-  108 (40.63/53.52)	.............................................................................................STLIDF.lLHRtYAELTV.LADLLPRKtDMERKIEIVQFASRTRQLFVRLLAL.........V..KWANNAgKVE.....KCAMISSFlDQQaILFVDTAdrLASlardalVH......................................
  140-  347 (308.17/199.12)	IPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVAN...GRVKFRVEGefeatltvmgddpdiPWRLLKLEILVEDKETGDGRALVHSMQINF..IHQ.LVQSRL.FADEKPLQ.DMYSCLHSFCLALQLEVLHSQTLML.........IRERWGDLV.QVERYHagKCLSLSVW.NQQ.VLGRKTG..TAS......VHKVTI.KIDE.....TDVSKPLQI..SHEPPLPACDsKL
  649-  847 (262.29/140.00)	IPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANcplNSTSSREQG...............PTRHVYLTYENQLSEPVGGRKVVEMFLNDWnsIAR.LYECVLeFA..RSLP.DIPNHLNVFS...EVRIYNYRKLILcygttkgssISIQWNSIL.Q..KFH....ISLG.......TVGPNSG..CSN......CHNTILhQLQEmfnktPNVVQLLQVlfDTQAPLNAIN.KL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.40|      55|     509|     407|     469|       4
---------------------------------------------------------------------------
  409-  469 (93.20/87.51)	GRSECLHVFVDLHSGMFQlmlYGVDQltlDDIEKS.VNDD.MKRIIPWLQ.QLKFWLGQQR..CKQ
  920-  979 (81.20/52.71)	GLKTFLNMFVDSNQDARR...RSVNE...DDNPPSpIGGDmMDSLISQLQpQQPPQQPQQQpfAKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.65|      30|     829|     496|     525|       5
---------------------------------------------------------------------------
  496-  525 (54.94/29.39)	SKHKLFIKLTR...LPQ..YYIVVE.MFDVPGNPTE
 1328- 1363 (38.71/18.84)	SKMLFFLQLTQkttVPQeaVSIIVPiIYDMASGTTQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01369 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWA
932
1137










Molecular Recognition Features






MoRF SequenceStartStop




NANANA