<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01356

Description Mediator of RNA polymerase II transcription subunit 1 (Fragment)
SequenceETEKLNKMSTLLERLHAKYNQNRPWTETMKLVRQVMEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVILHENNVPRSLGMNVSVTVEGTMAMYKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQGCTGIPLFDTPPFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPTTNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYASQALTTLGVQVLGADGGENKFKGSNQSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGSNMAGPGIDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGQSKSSAQSVGKPGSSPITKHGLSSGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSMKPESWSKSPISADQSLSMASSAILSAERPSRPSPEFLIGEEDDDLMDVALIGN
Length1573
PositionMiddle
OrganismAptenodytes forsteri (Emperor penguin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Sphenisciformes> Spheniscidae> Aptenodytes.
Aromaticity0.05
Grand average of hydropathy-0.655
Instability index54.53
Isoelectric point8.88
Molecular weight167319.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01356
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1069.90|     184|     184|    1099|    1282|       1
---------------------------------------------------------------------------
  555-  738 (196.64/44.75)	TNTFP..GGPITT.LFNMS...IS....M...........KERHDSVGHGE...DFSkvsqnpiltsllqitgnvgstigSSPTPPH.............HTPPPVS.....SPASN.TKNHPMlMN............................L..LKENPPQDFSTLYGSS....PLERQNSSSG..SPRMEMG..PG......gnkqkKKKSRMPADKPKHQ.TEDDFQRELFSMDV.........DSQ..NPifDVN..MTADT....................................LDTPHI...TPAP.....SQCSTP
  739-  969 (193.00/43.78)	PTTYP..QPIPHS...QPS...IQRmVRL...........SSSDSIGADVT...DIL.......................SDIAEEA.............SKLPTTNE..DCPPI......GTP.V..RDSSS......SGHSQSALFD...PDVF....QTNNSENPYTDPAD....LIADAAVSPN..SDSSNHFFPDGvdfnpdllnsqSQSGFGEEYFDESSqSGDTDDFKGYASQAlttlgvqvlGAD..GG..ENKfkGSNQSdtvdfsiiaaaskalgssdimehhsggqspllntgdLGKEKS...QKRV.KEG..NGSGS
  970- 1159 (221.90/51.45)	NMAGPgiDGKPGKrSRTPSsdgKSK.EKLpkrkkqetdgkSPSHS....................................SSNRPF...............TPPASTggSKSP....GSSGRS.QTPPGVATppipkiTIQIPKGTVT...VGKP..SSHGQYTSSGSVTSSS....SKSHHSHSSS..SS....SSSSS...........STSGKIKSSKSEGS.SGSKMSSSLYSSQG.........GSS..SG..QSK..SSAQS....................................VGKPGS...SPIT.KHGLSSGSGS
 1160- 1339 (281.61/67.29)	TKMKP..QGKPSS.LMNPS...MSK.PNI...........SPSHSRPSGGS...DKL.......................ASPMKPV.............PGTPPSSK..AKSPISS.GSGGSH.MSGTGSSS......SMKSSSGMGS...SGSM..SQKPPPSSNSSTASSS....SFSSSGSSMS..SSQNQHGSSKG..........kSPSRNKKPSLTAVI.DKLK.HGVVTSGPG.........GDDpmDG..QMG..PSSNS....................................SSHTMS...S....KHNMSGG...
 1340- 1542 (176.75/39.47)	...EF..QGKR............EK.SDK...........EKSKVSVSGGSvdsSKK.......................TSDSKNVgstgvakiiiskhDGGSPSIK..AKVTLQKpGEGG.....GDSLRP......QMASSKSYGSpliSGSTpkHERCSPSHSKSPAYTPqnidSESESGSSIAekSYQNSPSSDDG.....irplpeYSSEKHKKHKKE....KKKVKDKDRDRDR.........DRD..KD..RDK..KKSHS....................................M.KPESwskSPISaDQSLSMASSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.42|      12|      37|     195|     209|       3
---------------------------------------------------------------------------
  195-  209 (18.29/18.65)	ILHGSVgylTPRSGG
  233-  244 (23.13/12.62)	ILHENN...VPRSLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     247.42|      86|     103|     322|     423|       4
---------------------------------------------------------------------------
  323-  423 (123.23/128.77)	DTPpfvplyelITQFELSKEADPL.......PLNHNMrFYAALPGQQ..H..CYfLNKDapLPDGRSLQGTLISKIAfQHPGRVPLILNLIRHQVayNT.........LIGSCVKRTVLKE
  424-  530 (124.18/79.60)	DSP.......gILQFEVCPLSDSCfsvsfqhPVNDSL.VCVVMDVQDstHvnCK.LYKG..LSDALICTDDFIAKVV.QRCMSIPVTMRAIRRKA..ETiqadtpalsLIAETVEDMVKKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.90|      14|     104|     143|     156|       5
---------------------------------------------------------------------------
  143-  156 (25.31/18.23)	SKHLRGLVNLYKLP
  248-  261 (25.59/18.53)	SVTVEGTMAMYKLP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01356 with Med1 domain of Kingdom Metazoa
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