<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01355

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceAELTGIKWRRYNFEGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVDVIHRELHMVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFIRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPMSQNAANTGGHINVGQQGLGSVKDPASTCGMPLTPPTSPEQAVMGESGCSQSNISHSAVQEGTVSVHSPKKSGKITPKFHSHMVHRVWKECILNRSQSKRNQITTANLEEEVPNNTVSWDFVDPVQRVSCSCSRHKVFKQRCAAGSSRPPTINQPGFSVGTSSSSSLPPPASSKHKTTERQEKGDKLQKRPMMPFHHRPSVTEELCMEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQINMNPMDSPHSPTSPLPPTLSPQPRGQEAENLDPPSIPVNPALYGSGLELQPLPSLDDRTVLVGQRLPLMAEVSETALYCGIIQNNESLDMWRTYSVPSSDDPEFRPPDLPCERYDAKMEINSDSTALKRLLAQPNKRFKILEEQKPVQTLNYLDPLPLIQQPGEGLGDASDPYTFEDGDIKYSFTGNKKCKLGAEKDPLKKNKSEDGIGTKEIPTTGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAGRVGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMSYKDGISSETVTTLGMMESPMVNMVPTQLAEFKMEVDDGLGSPKPEEIKDFSYVHKVPSFQPFMGSSVFAPLKILPSQCLLPLKIPDACIFRPSWAVPPKIEQLPLPPAATFIRDGYNNVPSVGSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMICQSNLISQMGEGARRTHQPPMSLLLLLQNQHTQPFTSLSCLDYMSSNNRQTLPCMNWSYDRLQADSNDSWIECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLDGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWGTEECDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLLPPKYQTPAPASQTQTVPGNTGPVPSSSTCLSAAGAPPTGSSFNSTPSGGTTSLPAGSSSSSGSSVPQLSASSATPSVNQMTATSAPGFSGNIGSGQNTSTGGNTADRSQGSTGPGGDTESSQNLPQQQQEGQEGVTERERIGIPTEPESADSNAYPPAVVIYMVDPFTYTADEESASTNFWLLSLMRCYTEMLDNLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPNRSRRSKLSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISSADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDMDNDIRILITGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length2193
PositionMiddle
OrganismAptenodytes forsteri (Emperor penguin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Sphenisciformes> Spheniscidae> Aptenodytes.
Aromaticity0.07
Grand average of hydropathy-0.398
Instability index59.57
Isoelectric point5.61
Molecular weight241352.55
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01355
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.27|      37|      37|    1528|    1564|       2
---------------------------------------------------------------------------
 1528- 1564 (63.51/28.58)	SSTCLSAAGAPPTGSSFNSTPSGG.TTSLPAGSSSSSG
 1566- 1603 (53.76/22.85)	SVPQLSASSATPSVNQMTATSAPGfSGNIGSGQNTSTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.88|      31|      37|       8|      41|       3
---------------------------------------------------------------------------
    8-   41 (55.03/37.67)	WRRynfEGHGDCGPIISAPAQDDPILLSFI.RCLQ
   48-   79 (58.85/32.10)	WRR...DVKPDCKELWIFWWGDEPNLVDVIhRELH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.21|      12|      17|    1207|    1218|       4
---------------------------------------------------------------------------
 1207- 1218 (22.19/10.61)	QNQHTQPFTSLS
 1226- 1237 (25.01/12.92)	NNRQTLPCMNWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     423.08|     104|     713|     241|     350|       5
---------------------------------------------------------------------------
  241-  345 (171.75/78.04)	FPVAVEVIVGGVRMVyPSAFVLISQSDIPMSQNAANTGGHIN....VGQQGLGSVKDPAS.TCGMPLTPPTSPEQAVMGESGCSQSNISHSAVQEGTVSVHSPKK..SGKIT
  505-  539 (30.48/ 6.19)	............................PLSIPARNPSKQIN....MNP..MDSPHSPTS.....PLPPTLSPQ......................................
  719-  772 (60.60/21.15)	.........................................N....KSEDGIGTKEIPTT.GHSTPV...........PD.GKDAMSIFSSAPKTDTRQDNAAGRvgSGSLT
  961- 1065 (160.26/68.86)	LPPAATFIRDGYNNV.PSVGSLADQDYLQMNTPQMNTPVTLNstapASNSGAGVLPSPATpRFSVP..TPRTPRTPRTPRGGGTAS..GQGSVKYDSTDQGSPAS..TPSTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.31|      29|     713|    1350|    1381|       6
---------------------------------------------------------------------------
 1350- 1381 (51.28/39.91)	SEESPEPLPIPTLLVGYdkdFL.TISPFSLPFW
 2066- 2095 (50.04/30.28)	SREAPEELKQQPLALGY...FVsTAKAENLPQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.38|      20|      28|    1108|    1134|       9
---------------------------------------------------------------------------
 1108- 1127 (40.85/39.05)	CICACNMNIK.GADVGLYIPD
 1138- 1158 (34.53/15.83)	CGFSAIMNRKlGYNSGLFIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.10|      58|    1267|     132|     191|      10
---------------------------------------------------------------------------
  132-  191 (98.89/77.10)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHI.HMAQSSPSPF.QVLVS.....PYG
 1402- 1466 (89.21/60.37)	PENEA.LLDGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGImRVGKTVAQKLtDELVSewfnqPWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.83|      16|     136|    1683|    1700|      11
---------------------------------------------------------------------------
 1683- 1700 (26.44/22.13)	W...LLSLMRC.YteMLDNLPE
 1703- 1722 (20.39/ 9.78)	RnsfILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.57|      27|      27|    1842|    1868|      12
---------------------------------------------------------------------------
 1842- 1868 (47.29/32.32)	IDLPNRSRRSKLS.ARKIGLQKLWEWCI
 1871- 1898 (43.27/28.85)	VQMTSLPWRVVIGrLGRLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      11|     108|     839|     849|      13
---------------------------------------------------------------------------
  839-  849 (23.46/10.06)	FPTPPSLEQHP
  950-  960 (22.68/ 9.47)	WAVPPKIEQLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.08|      12|      16|     661|     672|      16
---------------------------------------------------------------------------
  661-  672 (22.66/16.00)	QKPVQTL.NYLDP
  677-  689 (18.42/11.06)	QQPGEGLgDASDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.66|      18|     144|     417|     440|      20
---------------------------------------------------------------------------
  422-  439 (34.33/23.93)	NQPGFSVGTSSSSSLPPP
 1998- 2015 (36.33/ 9.74)	NEDGFSPTNDDMFDLPFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      26.43|      10|     108|     459|     495|      21
---------------------------------------------------------------------------
  448-  457 (17.11/34.49)	ERQEKGDKL.........Q
  477-  495 ( 9.33/ 9.80)	EQDTSGQKLglagmepslE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01355 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAEKDPLKKNKSEDGIGTKEIPTTGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAGRVGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPV
2) GSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQ
3) KDPASTCGMPLTPPTSPEQAVMGESGCSQS
4) NLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
5) PPKYQTPAPASQTQTVPGNTGPVPSSSTCLSAAGAPPTGSSFNSTPSGGTTSLPAGSSSSSGSSVPQLSASSATPSVNQMTATSAPGFSGNIGSGQNTSTGGNTADRSQGSTGPGGDTESSQNLPQQQQEGQEGVTERERIGIPTEPESA
6) RCAAGSSRPPTINQPGFSVGTSSSSSLPPPASSKHKTTERQEKGDKLQKRPMMPFHHRPSVTEELCMEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQINMNPMDSPHSPTSPLPPTLSPQPRGQEAENLDPPSIPVNPALYGSGLELQ
710
979
292
2029
1503
410
854
1077
321
2071
1652
567










Molecular Recognition Features






MoRF SequenceStartStop




NANANA