<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01348

Description Mediator of RNA polymerase II transcription subunit 12-like (Fragment)
SequenceFQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGTGKLFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSNNVNSLKSEDFHMRGLLDELNEDEIWGSSHTLKSCGKAVSIETASLSEYARYVLRTICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGIRECTEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCTKEPGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPNSVGNADTSNTRQNGKKTFLSSSERRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSNASQGGPEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHTHTKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELSDQGKLATDDEKKTKGRKRKSKSSSRADEYPQNNLYRVPPTYSPISSQMMHHPQSALWGYNIMGQPQQPGFFVQNQPLPPGGSRLDPTGSFVPTNTKQALSNMLQRRSGTMMQPPSIHAITPQQQLLQMKLLQQEQQQQRLLRQQAQSRSLQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVNQYGHPSHF
Length1104
PositionKinase
OrganismAptenodytes forsteri (Emperor penguin)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Sphenisciformes> Spheniscidae> Aptenodytes.
Aromaticity0.06
Grand average of hydropathy-0.401
Instability index55.27
Isoelectric point7.53
Molecular weight123354.21
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01348
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.46|      19|     147|      54|      72|       1
---------------------------------------------------------------------------
   54-   72 (36.79/20.26)	VFEGLCGVVKHV..VNPS....ECS
  202-  222 (28.78/14.43)	VVKALCCSSNHVwgFNDL....LCS
  246-  266 (20.90/ 8.71)	CF.SLEDVVQHV..ALPSllaaAC.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.38|      24|      26|    1040|    1065|       2
---------------------------------------------------------------------------
 1040- 1065 (37.61/26.76)	QQEQQQQR...LLRQ.QAQSRSlQQfPRQG
 1067- 1094 (36.77/17.62)	QQTQQQQQtaaLVRQlQKQLSS.NQ.PQQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.92|      28|      34|     418|     451|       3
---------------------------------------------------------------------------
  393-  411 (19.90/ 6.35)	......................ARYVLRTICQQEWVGEhCL
  418-  451 (45.03/44.49)	CTDKdlildpVLSN......KQAQKLLQLICYPHGIRE.CT
  460-  488 (33.99/20.25)	HIKR......ILQNldqwtlRQSWLELQLM.....IKQ.CT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.19|      25|      26|     658|     682|       4
---------------------------------------------------------------------------
  633-  662 (29.93/17.34)	REGLLTSLQNQVNQIlsnwrEERYQDDVKA
  663-  687 (41.26/26.81)	RQMMHEALQLRLNLV.....GGMFDTVQRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.74|      22|      26|     690|     713|       5
---------------------------------------------------------------------------
  690-  713 (33.60/29.59)	WTTDwaLLLLQIITSGTVDMQTNN
  716-  737 (36.14/23.21)	FTTV..LDMLGVLINGTLASDLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.73|      16|      21|     966|     985|       6
---------------------------------------------------------------------------
  966-  985 (27.76/21.97)	GynimGQPQQP.GFFVQ...NQPL
  988- 1007 (20.97/ 7.82)	G....GSRLDPtGSFVPtntKQAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.20|      18|      21|     926|     943|       7
---------------------------------------------------------------------------
  902-  925 (20.49/ 9.48)	R....KSGELSDQgklatdDEKKTKGRK
  926-  943 (30.94/18.05)	R....KSKSSSRA......DEYPQNNLY
  944-  965 (27.77/15.44)	RvpptYSPISSQM......MHHPQSALW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     301.12|      98|     187|      89|     199|       8
---------------------------------------------------------------------------
   89-  199 (158.29/139.81)	CS...HL.RSKFGDLFSSACSKVKQTIYSNvqpSNSNLLWDPEfmlDFIENPSAHSI..NYSMLG..KILSDNAANRYS..FVCNALMnvcmghqDAGRINDIANLCAELTACCTVLS......SEW
  279-  392 (142.83/95.92)	CRlllHLfRTPQVCLFPQGTGKLFPGIRSS...CDRHLLAAAH...NSIEVGAVFAVlkAILMLGdaEIGSNNVNSLKSedFHMRGLL.......DELNEDEIWGSSHTLKSCGKAVSietaslSEY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.01|      23|      32|     818|     841|       9
---------------------------------------------------------------------------
  795-  816 (21.69/ 6.33)	IDTKgNKIAGFD......SID.KKQARGL.
  818-  840 (41.44/21.19)	VSTK.QKVSPWD......LFEGHKNPAPLS
  847-  875 (30.88/14.65)	VRVD.RKVIKYEeqqhllLYHTHTKPKPRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.18|      11|      32|     524|     534|      10
---------------------------------------------------------------------------
  524-  534 (19.92/13.51)	SSNSGIGLFNP
  557-  567 (19.26/12.80)	SERRGVWLVAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01348 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQRLLRQQAQSRSLQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVNQYGHPSHF
2) RSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELSDQGKLATDDEKKTKGRKRKSKSSSRADEYPQNNLYRVPPTYSPISSQMMHHPQSALWGYNIMGQPQQPGFFVQNQPLPPGGSRLDPTGSFVPTNTKQALSNMLQRRSGTMMQPPSIHAITPQQQLLQMKLLQQ
1044
874
1104
1041










Molecular Recognition Features






MoRF SequenceStartStop




1) RSYYLEPLPLP
874
884