Description | Mediator of RNA polymerase II transcription subunit-like protein |
Sequence | MGDRLTQLQDAVDQLAQQFVAALHFVHKRHDLEVLGPNDKVRDVNQEPEQREVDPLPADEFRAGMSELSRDLITKEQQIEYLISMLPGLQNSKQDQDRLIKELEEELKAAEADRQVALKERDQVLAELDKVIRSIRRP |
Length | 138 |
Position | Middle |
Organism | Acremonium chrysogenum (strain ATCC 11550 / CBS 779.69 / DSM 880 / JCM 23072 / IMI 49137) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreales incertae sedis> Acremonium. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.742 |
Instability index | 51.02 |
Isoelectric point | 4.85 |
Molecular weight | 15948.81 |
Publications | PubMed=25291769 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi transcription coactivator activity GO:0003713 IEA:EnsemblFungi transcription corepressor activity GO:0003714 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP01344 No repeats found |
MoRF Sequence | Start | Stop |
1) VALKERD 2) VNQEPEQREVDPLPADEFRAGMSELSRDLITKEQQIEYLISMLPGLQNSKQDQDRLIKELEEELKAAEADR | 116 44 | 122 114 |
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