<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01339

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMATLMLDDDEFKSLEHIVSRLSQLSSSIQSLRIDILKSNPLPHPSSLQASAQIIQRNLQSLLDSISENSDLLNRLAVRPSPNFPGRTQENALGQLLRKKLEPDVEELVAKGREAAVAATPEGLARMQEVWDDALRWVQQRIAQYVAEEAGDVYTKEEREMGVENVRTGLRRDLDEDEEDEDEDEDEGAGGEGEGEGDGDDNNQKKEGREKREKRGPEPETLLWFAARGDFAVPPNVEYERKQDAYRGLQGVSVPP
Length255
PositionHead
OrganismAcremonium chrysogenum (strain ATCC 11550 / CBS 779.69 / DSM 880 / JCM 23072 / IMI 49137)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreales incertae sedis> Acremonium.
Aromaticity0.04
Grand average of hydropathy-0.875
Instability index53.09
Isoelectric point4.51
Molecular weight28562.10
Publications
PubMed=25291769

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364144
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01339
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.26|      38|      44|      14|      56|       1
---------------------------------------------------------------------------
   14-   56 (52.82/36.08)	LEHIVSRLSQLSSSIQslRidiLKSNPLPH.PSSLQASA..QIIQR
   58-   98 (53.44/25.82)	LQSLLDSISENSDLLN..R...LAVRPSPNfPGRTQENAlgQLLRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.99|      21|      44|     112|     132|       2
---------------------------------------------------------------------------
  112-  132 (37.11/21.96)	REAAVAATPEGLAR.MQEVWDD
  158-  179 (31.87/17.98)	REMGVENVRTGLRRdLDEDEED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.07|      10|      18|     225|     234|       3
---------------------------------------------------------------------------
  225-  234 (20.20/11.61)	AARG..DFAVPP
  244-  255 (15.87/ 7.88)	AYRGlqGVSVPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01339 with Med8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EEAGDVYTKEEREMGVENVRTGLRRDLDEDEEDEDEDEDEGAGGEGEGEGDGDDNNQKKEGREKREKRGPEPETLLWFAARG
147
228










Molecular Recognition Features






MoRF SequenceStartStop




1) LRIDILK
2) NQKKEGREKREKRGPEPETLLWFAARGDFAVPPNVEYERKQDAYRGLQGVSVP
31
202
37
254