<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01338

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETGDYETNIFLIDNISSVAYRVYEPSSDHSQAFASAAIEVEGTLRDDGHLVFYDTTRRGIWHFRIQEKAAAGDAAGADLGYSLAVCGHALGLVEEGSFEPLSLQKGRPQHPPTNNTPTSSSSTGSGLGYPVYASPQSSNPNTNDQVAVGSSTADPWPAQTPQKTAYENFIAAVLLAFTTAFCPATGAIPLNYRTVLLPHNHATSDDKGDTLFAQDAIFGTLVAYLTTLGSLVVSFKVSQCRGLLPMDNMFAAGFNSPGQNILAAPFGIQATNPLAALGDIGTASLAQTPNTQALSFRGPPDANEGTWRQSCLKALQFRGIPASLLEGCPWVSISISRRRLQAAKGDARRIKDAPGPTIISWPGPLCFRQRVLEASATSRLGYSLLNGHEESHDPLGNAGRWLNTAADREEQLSKRKADRSAPAPVETDANGPQAPNPSGHTPAALGRPSTAVVDAMYPTPPDGVQPPSGITPSFDGGTSSPRNLVSAAAPGDSEDLATEMANTHSEIWDQPDTKRERRDSHNLLDGPENVLMGGGDMFGDSDENDITEADFSFFDEQPGGMDLAISDYGASGDSSPQKQSVPKQEEPEPSTAPSSTPPLQDSGGFMKPELKHARSLLNDSQNTRPAGEKTPTLKRSSSPFNQETVLKRVRGPTASIDDRVDSVPPPRRRSSFFQHINLGPTLSLINKKYEKGGIFAVEPRELEAPKPAKQQATVPETNYLQRRKKHSGKPKEIATPSGTLMRRLTALEPPASNGSLRRGPGSPSDDGASSVESDEDDSSYTSDDAISPIKTSFKRPTLDEDAVSPVNSFREVDATEEPDQQLAMELPKLSKPEPPEVQLSKLFLDPEPFSFQMPLSDEDVVNIGQFITEQAATGNLDVWDAHKEEEARSLARSKRQILSSYARDSLNAFRNVVPPPLERAISPQLKGFLEVPDVPLVGQPALLKPRPVPGRDPNAEQLKPSNLYQIPCHHLEVRRAESKLSVLPTAVTFWESLGLAPASGSKNIQAVCVFPGWTGMMDNVRTFLERMKSMYELLRLGSLEKLPLSSELEPGLVPFEVDRISTSPDASVTGHGSALIESMDVLQAAMSSVTATEINFVIVMTYTPSNPGTIVEACLAFQRFVDSYWKPLLKKEYAQRELVLQLVSADFVSSPTSLVMTGSSELVKLCIEAYDRCTMFDGPTPAPAIVLEQALPRIIDFKLTSTPSASLLHENSCIHVAYAQSVDERWVTAAWTDDRGSQQATASYCLGRKGRPLSISMQEVAHEIWESTLEIISRLKVHWRVIITKSGNMEPHEIEFWADLARTESKPNIAMILMTVDTSPSLQLLPPTVQVPSSTAGFYTTPVSTPQANIVSPEQSNTPATPMRDASAAAAPTPGADATGDADSDAVLLDVTDQTWGAVVGHRLNNSSTPLELQPALVSGYLIKRSSTKLEDPPSVMEVNLVHTEATARAYEPLLREMLSNFRGLSTLARARGVVEREADVRPWHVAAAEKAVRALYMLI
Length1501
PositionKinase
OrganismAcremonium chrysogenum (strain ATCC 11550 / CBS 779.69 / DSM 880 / JCM 23072 / IMI 49137)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreales incertae sedis> Acremonium.
Aromaticity0.06
Grand average of hydropathy-0.367
Instability index52.77
Isoelectric point5.12
Molecular weight162289.23
Publications
PubMed=25291769

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01338
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.41|      13|      16|     782|     795|       1
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  782-  795 (19.23/13.62)	TSD.DAISPIKtSFK
  798-  811 (19.18/ 8.65)	TLDeDAVSPVN.SFR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.06|      16|      20|     293|     308|       2
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  293-  308 (33.46/15.78)	QALSFRG.PPDANEG.TW
  314-  331 (23.60/ 9.05)	KALQFRGiPASLLEGcPW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     636.33|     165|     274|     903|    1069|       3
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  903- 1030 (194.08/110.78)	..........................................................................A.RDSLNAFRNVVPPP...LERAISPQLKG.....F..LEVPDVPLVGQPALLK...PRPVPGRDPNAEQLKPSNLYQIP.......CHHLEVRRAES.KLSVLPTAVTFWESLG.LAPASGSKNIQAVCV....FPG..WTGMMD..NVRTF..LERMKS
 1031- 1137 (111.21/67.43)	MYEL.LRLG...SLEKL..PlSSELEPG...L.VP.....FEVDRISTsPDASV....................................................................................................tghgsalIESMDVLQAAM.S.SVTATEINFVIVMT.YTPSNPGTIVEA.CLafqrFVDsyWKPLLK....KEY..AQR...
 1138- 1306 (177.10/100.78)	..ELvLQLV...SADFVssP.TSLVMTGsseL.VK.....LCI..............................eA.YDRCTMFDGPTPAPaivLEQAL.PRIID.....FklTSTPSASLLHENSCIHvayAQSVDERWVTAAWTDDRGSQQAT.......ASYCLGRKGRPlSISMQEVAHEIWEST..LEIISRLKVHWRVII....TK....SGNMEphEIEFWadLARTES
 1312- 1485 (153.94/86.46)	MI.L.MTVDtspSLQLL..P......PT...VqVPsstagFYTTPVST.PQANIvspeqsntpatpmrdasaaaApTPGADATGDADSDA...VLLDVTDQTWGavvghR..LNNSSTPLELQPALVS...GYLIKRSSTKLED..PPSVMEVN.......LVHTEA.TARA.YEPLLREMLSNFRGLStLARARGVVEREA.DV....RP...W....................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     495.71|      88|     299|      76|     163|       4
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   76-  162 (144.65/68.85)	.............................................AGADLG.YSLAVCGHALG.LVEEGSF..EPLSLQKGRPQHPPTNNTPTSSSSTGSGLGYPVYASP...QSSNPNTNDQVAVGS.STADPW..PA..QTP
  163-  290 (70.45/29.34)	QktayenfiaavllafttafcpatgaiplnyrtvllphnhatsddKGDTLF.AQDAIFGTLVAyLTTLGSL.vVSFKVSQCRGLLPMDNMFAAGFNSPGQN....ILAAPfgiQATNP....LAALGDiGTAS....LA..QTP
  377-  433 (78.06/33.39)	.............................................ATSRLG.YSL.LNGH.......EESH..DPLG.NAGRW..................LNTAADREE...QLSK.RKADRSAPAP.VETD.....A..NGP
  434-  515 (100.57/45.38)	Q............................................APNPSG.HTPAALGRPST.AVVDAMYptPPDGVQ......PPSGITPSFDGGTSSPRNLVSAAAP...GDSEDLATEMANTHS....EIWdqPD..TK.
  548-  632 (101.98/46.13)	.............................................TEADFSfFDEQPGGMDLA.ISDYGAS..GDSSPQK...QSVPKQEEPEPSTAPSS..TPPLQDSG...GFMKPELKHARSLLN.DSQNTR..PAgeKTP
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.59|      15|      21|     707|     724|       5
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  707-  724 (15.16/20.18)	KPaKQQATvPeTNYLQRR
  730-  744 (27.43/15.21)	KP.KEIAT.P.SGTLMRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.50|      32|     107|     640|     673|       6
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  640-  673 (53.59/35.66)	PFNQETVLKrvRGPTASIDDRVDSVPPPRRRSSF
  750-  781 (57.91/32.90)	PPASNGSLR..RGPGSPSDDGASSVESDEDDSSY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.29|      12|      21|     169|     181|       8
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  169-  181 (15.29/14.11)	NFiAAVLLAFTTA
  192-  203 (23.00/15.85)	NY.RTVLLPHNHA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01338 with Med13 domain of Kingdom Fungi
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