<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01337

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGGQGGAQSDHGRDPKANGVNGAGTQAPAKDAAAATTQAGDRPLELRPSRMNDLPDEIVHITEGFVPLSLLLTRLAQTTHNSLQDKIVELAKMPTPAGAVNGNSTHPAGDDASSENLRKKSALLNFAQEMHAKWVKALVIAEWSRKSEMVSKLIDLKWHIDQQRILYDTMLDQIVHVKRDLTYARVPSPDLKTALQVLSTGSAPWMPDLQYIEPPPLDAEEVLKWMDNVNTLLSLRLNLEEFDKIPPQFKNYGIDSGRVTFKVDGEFEVDLTIADEDFEKQLWFIDFRFSFTPAAASISESLRGYLESCVNDALAKDGLTGCYQFLHEFVLTCKINELRRQALHLSKTSWTGTLKVEPLHRALAIQYWTCRMPPTIPKSWVLIAVNSGSKRKIPDGVRPTSYLEVKWYRDGKVVTDVDLTLDIGNLSAETLLRNAIGHHIEFILRGIHDRLLETPRFKKHELRISLDTSYDNPAESRLTTQVAHSTTVSLLIEPKTGVFAIKPSSKFTVQQEHKLNNGPNHIEGGFLCLEDVRCAFMEDGIYRRSSPLGWLATRPAIKDDELRSMTKIRDWTRVIWLQRKGWTANWSLVVILSLGGDEWWLVETSPEASRAQRSQVKLPLGSGPPDLSEQFWHGLTILSTALISQNIDKGELHRQEIWYRPSERLSMPTRLIRMPALDISLAAIFPTMVHDPSKDPNHDVPATAFGGQSQALTRRRPTTSTALSPRQAWAMDIVSVRFKMLQAPSRSEAHDDADPSAQRLLCVSEAIVQVRKSAKLATLKGRVDRTVYYDHLNGEFYLLLRHPVGEPILGVLKSRIVAIDRFVCFLEALEKCKGTIESENVSLRGVSFFYGQKPPQGSESNEGAPAQRLRVGLDLSKDKVDVRLEKGNPHLRVIDIMKALVNLDGGISTLMSWLPTSLPTMTAIDAIDTAWEDIQVRAQGRVEIVFRAIDWMAIRYTIMGTNDAGQRVPRRLILEARVRIRRNGLWWHIWRYHSNNNNDRNKKEDRFDAALKSVWDGRGEWWQGFGASAAGRTSDGAATMLHKIDEAIRGLVGNLDGDEGFASTEPPQNQPHLPQPPQPSSSQQQQQQRQQQQQQQQQQKKKPQPKSGKAPDQAIEIG
Length1120
PositionTail
OrganismAcremonium chrysogenum (strain ATCC 11550 / CBS 779.69 / DSM 880 / JCM 23072 / IMI 49137)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreales incertae sedis> Acremonium.
Aromaticity0.07
Grand average of hydropathy-0.439
Instability index45.95
Isoelectric point8.16
Molecular weight125780.68
Publications
PubMed=25291769

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01337
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.10|      14|      18|     340|     353|       1
---------------------------------------------------------------------------
  340-  353 (25.43/14.25)	LRRQALH..LSKTSWT
  356-  371 (21.67/11.12)	LKVEPLHraLAIQYWT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.49|      16|      19|     871|     889|       2
---------------------------------------------------------------------------
  871-  889 (17.65/24.20)	LRVgLDLSKDKVDvrLEKG
  893-  908 (27.83/19.60)	LRV.IDIMKALVN..LDGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.26|      17|      18|     207|     223|       3
---------------------------------------------------------------------------
  207-  223 (34.14/20.90)	WMPDLQYIEPPPLDAEE
  227-  243 (26.12/14.22)	WMDNVNTLLSLRLNLEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.61|      17|      18|     151|     167|       5
---------------------------------------------------------------------------
  151-  167 (29.09/20.50)	MVSKLIDLKWHIDQQRI
  172-  188 (27.52/18.98)	MLDQIVHVKRDLTYARV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.13|      31|     458|     596|     632|       7
---------------------------------------------------------------------------
  596-  632 (46.28/35.95)	LGGDEwWLVETSPeasraQRSQVKLPLGSGPPDLSEQ
 1057- 1087 (59.85/30.48)	LDGDE.GFASTEP.....PQNQPHLPQPPQPSSSQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.01|      37|      57|     692|     728|       8
---------------------------------------------------------------------------
  692-  728 (66.65/49.15)	HDPSKDPNHDV..P.ATAFGGQSQALTRRRPTTSTA.LSPR
  744-  784 (48.36/33.29)	QAPSRSEAHDDadPsAQRLLCVSEAIVQVRKSAKLAtLKGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.98|      16|     458|      52|      70|       9
---------------------------------------------------------------------------
   52-   70 (26.20/21.75)	RMNDLPDeivHITEGFVPL
  516-  531 (31.78/18.30)	KLNNGPN...HIEGGFLCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.15|      25|      33|     941|     965|      14
---------------------------------------------------------------------------
  941-  965 (44.11/26.97)	QGRVEIVFRAIDWMAIRYTIMGTND
  977- 1001 (48.04/30.06)	EARVRIRRNGLWWHIWRYHSNNNND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01337 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HDPSKDPNHDVPATAFGGQSQALTRRRPTT
2) LQDKIVELAKMPTPAGAVNGNSTHPAGDDASSE
3) MENGGQGGAQSDHGRDPKANGVNGAGTQAPAKDAAAATTQAGDRPLELRPSRMND
4) VGNLDGDEGFASTEPPQNQPHLPQPPQPSSSQQQQQQRQQQQQQQQQQKKKPQPKSGKAPDQAIEIG
692
85
1
1054
721
117
55
1120










Molecular Recognition Features






MoRF SequenceStartStop




1) QQQQQQRQQQQQQQQQQKKKPQPKSGKAPDQAIEIG
1085
1120