<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01335

Description Mediator of RNA polymerase II transcription subunit-like protein
SequenceMTSRTPMGVQQRQPQRSLSSQRPAPSQRTISQQHLPSSPARKESSFGDLTTSSDWPDALQSRHGTSTPRRGGSRLRLELSSDHGFGSQVAAESPQSFASARPLQATDGLDAANSPALSRASHQDTDNPPMPMPKRPQLTTARTPIPRRPAPAPSAAKKDNRPKPYTFEEPREAPRMPTKNRNEHRTSDPFGKGLFSGRADFYPWKGKHLEDEWTNESIGKGVWEKYSSSESSSARLAIFPALKQKTGLNALSTIFMGVLNQRRQRGQVNTPSTFKPPPRVTLTDTKREVWLRDLANPATSLRRLSRTIPHGIRGRALLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGVNGAIVMGGEIKWCKDWTVFVEQFVDSVVSATNEEGWKAKATYAIRLATSLYSEYLLDRDHYLDWVISGLEGSAQGRLPMCMLLVRIYWADMLRSRKYGRRLVAALLSHVHSIHNDPDRDILSQLGSQLSIMLASLIKSNPESFIYPSAWTRYRDTLRAVLPADDEVARKAYSRINSRNLRLAVAGNTYPPAGRQRLVRLLDSTFQNSVEADLPAKCWAASDDKAQLVKALIEWATSVHRPGLAKVYTASRLLKNFKAWSTAVPLDATTAVLEVMDDIEADDQNRKSHMYHLVSELIRDRIFSVPQYLQWLISRGGFHDESEVDPESGPCAARLLIEIPVDSLPTRLKKERANLLRRAGNYSVAAEEVDMSNGLKCVRRTLGLPLAPDDPLNQRNPMPMRKLLTRLRNSNRALKCAISSHLREVMVQQGSGGGHQHASVAMLTSVRTILEVTEDFTMLSEVVQCCLKSSDAEILAACADTINANLSIFLALGSAPESFNLLIERLRMFGQQGAVPRPLLAAVCHLAQRMPGRAEVANQLRQDLLQSDRSNAIDACSPVSDSMVPQAHAGDGELSEEIDKLLATGNRIDHPTMNRLFRTIVPRLEAGWAKGDESCRAFASLLAKMRVFDTHHFDKLMSDWISHVRSLAKRPPLPDMYPLLVTTGCLTVSALLHTANASPPMTSNPPSNVESTDGSSATYLQELLALFLTKLPKTASLTQEEVYRFHIYQEAARSDNAATLLTLIRNTIAEYAALRGQHPGLSLPLDSDNLRDRILDALRLLVVADAPAASEALSVTGLPQGATSLVSTMTTKLLLPGAAEDCPISFDQILGLATELTLPFCQLKLEFDLSVNESNPSASEDPTQSRFELFSSAMDRAIEANNITWTSMLPCLSGDISQHLKGLALGRLITLIPSLKSRQASDAVSDDHAHLAENLLGVIEAITTGQTPASSPQLTSSLADKLCDLCEIVAAKDRELDDLRATVLEHWLPAVLRLIILQGKGSDSASLAGPTAGGKPPAPVNHEARGRIVIALCSVLLELPRLPAEAVGDLAQQVFDVAILLVDDLPDDLRQQCAKNILLLPGSSTSTTLSSDPRVYYLLSTPQLTPADNLVLSHRDKSASLQSSGPRGMGAMYGIAPPIQERLTPFVMRRWEMLSESTPNIGENDTSLSLGLFEAIKIQ
Length1528
PositionKinase
OrganismAcremonium chrysogenum (strain ATCC 11550 / CBS 779.69 / DSM 880 / JCM 23072 / IMI 49137)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreales incertae sedis> Acremonium.
Aromaticity0.05
Grand average of hydropathy-0.276
Instability index48.01
Isoelectric point8.45
Molecular weight167788.49
Publications
PubMed=25291769

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01335
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.87|      82|      89|     809|     897|       1
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  809-  897 (123.83/94.80)	SEVVQCCLKSSDAEILAACA.D.TINANLSIFLALGSAPESFNLlierLRMFgqQGAVPRpLLAA......VCHLAQRMPGRAEVANQLRQDLLQSD
  899-  988 (127.04/77.96)	SNAIDACSPVSDSMVPQAHAgDgELSEEIDKLLATGNRIDHPTM....NRLF..RTIVPR.LEAGwakgdeSCRAFASLLAKMRVFDTHHFDKLMSD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     278.28|      88|     264|    1162|    1255|       2
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 1162- 1255 (137.01/122.16)	LLLPGAAEDCPISFD.QILGLateLTLPfcQLKLEFDLSVNESNPSASEDPTQSR.....FELFSSAMDRAIEANNITWtSMLPCLSGDISQHLKGLALG
 1427- 1520 (141.27/104.24)	LLLPGSSTSTTLSSDpRVYYL...LSTP..QLTPADNLVLSHRDKSASLQSSGPRgmgamYGIAPPIQERLTPFVMRRW.EMLSESTPNIGENDTSLSLG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     327.76|     116|     515|     485|     616|       3
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  485-  551 (86.94/53.18)	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLIKSNPESFIYPSAW.TRYRDTLRAVL...PADDEVARKAYSRINSRNLRLAVAGnTYPPAGRQRLVRLL
  552-  602 (51.63/50.83)	DSTFQNSVEADLPAKCWAASDDKAQLVkALI.....EWAT.SVHRPGLAKVYTASRL...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  995- 1056 (70.50/36.96)	.........................................................lknfkawstavpldattavlevmddieaddqnrkshmyhlvselirdrifsvpqylqwlisrggfhdesevdpesgpcaarllieipvdslptrlkkeranllrragnysvaaeevdmsnglkcvrrtlglplapddplnqrnpmpmrklltrlrnsnralkcaisshlrevmvqqgsggghqhasvamltsvrtilevtedftmlsevvqcclkssdaeilaacadtinanlsiflalgsapesfnllierlrmfgqqgavprpllaavchlaqrmpgraevanqlrqdllqsdrsnaidacspvsdsmvpqahagdgelseeidkllatgnridhptmnrlfrtivprleagwakgdescrafasllakmrvfdthhfdklmsdwishvrSLAKRPPLPDMYPLLV.TTGCLTVSALLhtaNASPPMTSNPPSNVESTDGSSA....TY....LQELLALF
 1064- 1155 (118.69/75.58)	ASLTQEEVYRFHIYQEAARSDNAATLL.TLIrntiaEYAAlRGQHPGLSLPLDSDNL........................................................................................................................................................................................................................................................................................................................................................................................................................rDRILDALRLLV...VADAPAASEA..........LSVTG...LPQGATSLV...
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.25|      59|     247|     396|     457|       4
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  396-  457 (95.25/67.52)	RLATSLYSEYLLDRDHYLDWVIS..GL..EGSAQGRLPMCM..LLVRIYwADMLRSRKYGRRlvAALL
  641-  705 (88.99/52.49)	HLVSELIRDRIFSVPQYLQWLISrgGFhdESEVDPESGPCAarLLIEIP.VDSLPTRLKKER..ANLL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     191.64|      56|     240|       7|      75|       5
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    7-   68 (90.79/65.10)	MGVQQRqPQ....RSLSSQRPAPSQRTISQQHLPssparKESSFGDLTTSSDWPDALQSRHGTSTP
  130-  189 (100.85/46.79)	MPMPKR.PQlttaRTPIPRRPAPAPSAAKKDNRP.....KPYTFEEPREAPRMPTKNRNEHRTSDP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.69|      25|     515|      95|     122|       6
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   95-  122 (38.17/27.39)	QSFASARPLQAT.......DGLDAANSpalSRASH
  607-  638 (38.53/19.94)	KAWSTAVPLDATtavlevmDDIEADDQ...NRKSH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.81|      26|      40|     285|     323|       8
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  285-  314 (37.03/48.72)	TKREVWLRDLAnPATSLRRLSRtipHGIRG
  328-  353 (46.78/23.03)	TERAVWLAKCV.GANEIRAFKR...KGVNG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01335 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRTPMGVQQRQPQRSLSSQRPAPSQRTISQQHLPSSPARKESSFGDLTTSSDWPDALQSRHGTSTPRRGGSRLRLELSSDHGFGSQVAAESPQSFASARPLQATDGLDAANSPALSRASHQDTDNPPMPMPKRPQLTTARTPIPRRPAPAPSAAKKDNRPKPYTFEEPREAPRMPTKNRNEHRTSDPFGK
1
192










Molecular Recognition Features






MoRF SequenceStartStop




1) AKKDNRPKPYTF
2) RLRLEL
156
74
167
79