<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01325

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFMKSKDDKNRVPYRLYTPPYVLAKSCEKSENTEAFGKTSLKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKNLKDICEQCALMHPISVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMLDVFRCWDDIPMQQINMPHSRPGSPSQFEGNQQSPGESKGAGARDGYGAHDSEEVGVVLQQPLAIGYLVSTAPTGRMPAWFWSSCPHMENVCPVFLRTALHLHTPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALASSITFTVIFVLLPKNITMLISILFCKSVENFSTEEFVAVYNKIFQSAADDIEAMENSIQWLNVWKVRQTKDIPICIRCTLAVLEARLFDLRSQRDGRENTTETKNIYAGAFTRFINFITEGSVAFRFNKATIADFVRGQGIETYMVELRHLCAHKSISVSIDVFRRSAQYCMDWLKVSYWERELALIQPVTIFTNKTVELRSTIKYGEMITCLRQYDVVSGGRASGFETVPELKAARKDDKDLQLLDEFDSTKLKVISESIVKHLREKLRPPPTSAGVRALCKSVLANCRRLLLYPPGWKEEPSVSAIYSDFFQYLAEVGCLQPFLEQLLAICENEAESDELRRGAQYWALKIAVGFRLLAQFKKTCKSLPAAQLIRFHQIKCPVTKKRARVVYTDFVNAALKTPRYQLVLGLTVDCPWHLNLSRVYLLDRLAAVNPYTREVVTVLLSLAQPTVKQSLQRKMTALMQTYTGEKVRKEDEMEFTKKITAVKSRSSKATDEELADIYTKEDFVKMVASKKRPAEERLEGQPETKRWGPWSESRAPIAWSSCPLGTYHIVVAK
Length1033
PositionMiddle
OrganismAnopheles sinensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.09
Grand average of hydropathy-0.224
Instability index48.24
Isoelectric point8.29
Molecular weight116789.06
Publications
PubMed=24438588

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
Las1 complex	GO:0090730	IEA:InterPro
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
endonuclease activity	GO:0004519	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
rRNA processing	GO:0006364	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01325
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.06|      68|     468|     357|     553|       1
---------------------------------------------------------------------------
   46-  117 (108.29/34.41)	RVPYRLYTPPyVLAKSCEKSENTEAFGKTSLKQQCSIMYCSYCLSEDQ..SWL.LAVATDDRgefLETVTINIDI
  391-  461 (109.77/215.86)	RTALHLHTPT.ILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNllSWLaMDSNTHDR...LSCLPIHVQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     278.55|      92|     260|     577|     744|       3
---------------------------------------------------------------------------
  577-  685 (134.67/195.15)	KNIYAGAFT..RFINFITEGSVAFRFNKATIADFVRgqgietYMVE..........LRHLCAHKSISvsiDVFRRSAQYcmdW.LKVSYWERELALIQPvtifTNKTVELRSTIKYgEMITC
  752-  856 (143.88/71.16)	RALCKSVLAncRRLLLYPPGWKEEPSVSAIYSDFFQ......YLAEvgclqpfleqLLAICENEAES...DELRRGAQY...WaLKIAVGFRLLAQFKK....TCKSLPAAQLIRF.HQIKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.11|      21|      33|     926|     951|       5
---------------------------------------------------------------------------
  926-  951 (31.05/33.40)	TVKQSLQRKMT..ALMQTYTgekvrKED
  960-  982 (30.06/19.34)	TAVKSRSSKATdeELADIYT.....KED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01325 with Med13 domain of Kingdom Metazoa
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