<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01319

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMNTKHKNQQNAAAAAQQQAQQEGGGGTSQQGGGMPDPINALQNLASQGTRPQMMDANGWHGGWAGMQGNRVGMGPGPGGQMGGMMGPNQMQGPGPGAGMVGGMPGQMGVNMGPGGMGSAKMGQGGPVQQMAVGPGGPNQMNPMVMGQIQAQLQNQNTMGGQQMGAVVGGGINPGNQMGPMVGANSGMNAQAMGMGGGGGPVGAIGGPIGGPGGPGGVPMQQALQQQAAAMGPNAVGGPNQMNPMGPGGGGGGGGVVGPGQGQMLVGAGQGGGGQQQQGGFVGMAGNPMVRKPPDMMPGGNVYPGGGGAVRSVTPNNFLRQSPSPTVPSPAGPGVHGPPSHPGQQMIPSPALIPSPNPVGGMGSVPQRSIGQSPGASLNTPGQPGGAVQSPLNPQDEQLYREKYRSLTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAISSTLQSANGNLTLQRTFRPCLEALYGPDIKNLPPPTKQPRQDDPSSGTAAAPGAGSSAGTGATSAPGGMGGGGNTGAGAGASSSSTQEIPHILQVEIARLDQKFKVSLDQCAISGTKTIKLMIKLDDMNLPCVPPVAVTIPEDYPYTAPTCSLIDQDYNGTPFLILVQKSFMARICKLPGFFTLSHLLDTWEMSVRQACSPNPTIVTPTATSVLLGM
Length759
PositionTail
OrganismAnopheles sinensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.03
Grand average of hydropathy-0.380
Instability index47.89
Isoelectric point8.93
Molecular weight77516.38
Publications
PubMed=24438588

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01319
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     366.42|      49|      49|     255|     303|       1
---------------------------------------------------------------------------
  102-  143 (57.96/ 9.18)	..PI.NAL.QNLASQGTR....P.QMMD.AN.GwHGGWAGMQGNRV.........GmG...P.GPG
  144-  179 (61.85/10.28)	G.QM.......GGMM......GPnQMQG.PG.P.GAGMVGGMPGQM.........G.V...NMGPG
  243-  280 (76.92/14.52)	G.PM..........VGANSGMNA.QAMG.MG.G.GGGPVGAIGGPI.........G.G...PGGPG
  281-  324 (70.72/12.78)	GVPMQQALQQQAAAMGPNAVGGP.NQMNpMGpG.GGGG....GGGV.........V.G...PG...
  325-  372 (48.25/ 6.44)	....Q...GQMLVGAGQGG.GGQ.QQQ........GGFVGMAGNPMvrkppdmmpG.GnvyPGGGG
  376-  407 (50.71/ 7.14)	SVTPNNFLRQ.....SP.SPTVP.SPAG.PG..........VHGP................PSHPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.51|      20|      23|     522|     541|       3
---------------------------------------------------------------------------
  521-  540 (32.64/18.98)	ALTSQL....GSIRETPTNNPLVE
  541-  564 (26.69/14.05)	AISSTLqsanGNLTLQRTFRPCLE
  565-  581 (24.18/11.97)	ALYGPD....IKNLPPPTKQP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.40|      71|     181|     420|     511|       5
---------------------------------------------------------------------------
  420-  511 (102.16/73.28)	PNPVGGMGSVpqrsiGQSPGASLNTPGQPGGAVQSPLNPQDeqlyrEKYR.SLTK.YI...EPLKRMIaKMenDDIDkiakmkrlLEILSNPSVRIP
  608-  683 (111.24/45.93)	PGGMGGGGNT.....GAGAGASSSSTQEIPHILQVEIARLD.....QKFKvSLDQcAIsgtKTIKLMI.KL..DDMN........LPCVPPVAVTIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.86|      23|     143|      74|      99|       6
---------------------------------------------------------------------------
   75-   98 (38.49/20.63)	NAAAAAQQQAQ...QEGGGGtSQQG...GG
  206-  234 (36.37/ 7.98)	NPMVMGQIQAQlqnQNTMGG.QQMGavvGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01319 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIKNLPPPTKQPRQDDPSSGTAAAPGAGSSAGTGATSAPGGMGGGGNTGAGAGASSSS
2) MAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFH
3) VREMNTKHKNQQNAAAAAQQQAQQEGGGGTSQQGGGMPDPINALQNLASQGTRPQMMDANGWHGGWAGMQGNRVGMGPGPGGQMGGMMGPNQMQGPGPGAGMVGGMPGQMGVNMGPGGMGSAKMGQGGPVQQMAVGPGGPNQMNPMVMGQIQAQLQNQNTMGGQQMGAVVGGGINPGNQMGPMVGANSGMNAQAMGMGGGGGPVGAIGGPIGGPGGPGGVPMQQALQQQAAAMGPNAVGGPNQMNPMGPGGGGGGGGVVGPGQGQMLVGAGQGGGGQQQQGGFVGMAGNPMVRKPPDMMPGGNVYPGGGGAVRSVTPNNFLRQSPSPTVPSPAGPGVHGPPSHPGQQMIPSPALIPSPNPVGGMGSVPQRSIGQSPGASLNTPGQPGGAVQSPLNPQDEQLYREKY
570
1
63
627
44
468










Molecular Recognition Features






MoRF SequenceStartStop




NANANA