<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01311

Description AGAP002523-PA-like protein
SequenceMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVSASKVGAYFNAILAKKEELMTLPDSGRKKQQINPKDNFWPVTARNKTTLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMKDLVPKLHEHYHQGPLQEKPSSGGSGGSGGMTGASSALGMSSAAGGANPSTIPPPLSSPAGSMHSPAGGNTGVGSMHPQQQQQPPPLSPQEEQRIAQKQWNYSTQLCKYMYEEGLLDKQEFLNWIIDLLEKMKSSPNADDGLLRIYLPLAMQYLHDFVQSERFCRRLAYAVAKKLAQLINQMAESHNINLASPDAEPGGKSSMDTQEGKDKSLEKPSKDGAVGGTPVQGDTKPTKANPFEMIFTEYLHCSHHRNVMLQLSTILQVITLECPTALVWCGVGETRSSSVLSGSPLDHLPVAPSALPMPERYEKSNEDIRRQLFEAEESIKVRSRHAESRWCIDKWQTAAGNASLKILATLDALDGHCFDRMDSNNSLDSLYSKIFPPFQVQPIKPAESVSNSGSGKGMQSGGQQSGATDGKDAATKQFEYNVEQDASIVKILCEWAVSWQRWGEHRAMVVAWLLDKRQNEVITALENDSYSNNLNNSDDKDSVLSGSGLNGGQPVFQHILMNFLDNDAPVLDESGGTQNKSQFTNLVHLFSELIRHDVFSHDAYMSGGMLSLDSQGICNAGLGTGPISNKPTTTSSPHNATGMDEDVLQTDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEQATPSVAGLGKAESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRSEFNFEATSNKCQAMSYFDQHVVTWQCAVQVQEMLNAFAIGNSNYLPVQEHVAFLFDLMESAFNIYGLIDTCIQILRELPEVEQQLIGKSSVALVRSYTTSLSLYVVGVLRRYHCCLLLSQEQTTAIFEGLCRIVKHVSNPSDCSSAERCILAYLYDLYSACSSLKSRPQQEPFHNAYPKIKQALYTPLQPSPSAHTYNPQFMIDIITNPRRGGKIESAWARQLNESASNRYSFVCNAVVAVTRDIDNDCLNDIAAMCAELTACCNSLSTEWLGVLIALCGSNRDAGYYVDVLSQVDVQNTNIHNALSVFTSILVARHCFSLENFVAHVALPSLVQACKGRGETTPEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITVGNAHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAHKVSSIFGTGKRSGLNTPVHPGSTPKSMAGSGDLSHILGTSDLSVLGNPDESMLDVSQQNSHLNQENATSLSDFAQHVLRQICSQEWVLERCLQNAEELCQQGMLIDNLLTAKQAQRLLHMICYPEHESNLIAELDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPELSNWLDMVARAAIDVFRVNEFCLSSATDVKQEKVKPSTWLVAPLVSKLPSAVQGRILKVSGQVLESTSMFSKNKDGNGGNSSSNNNSHSHGANSNSSVSSNGSTFGSKQSAQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYSQLSQFLQNRDQSLEMVGGIEDPCGFEKMLDALQLRYSLVGGLFDAIMKNATSTTDWAILFAQLISQGVIDLSNNSELFTTTLDMLATLIHSTLVSDSQTERDENKKLYTNLMKKLRKELGDRNGPSIKYVRQLLPLAKQTCEVITCDSAGSSTDAKGNKISIDSIEKKNGLRLGDKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLFKPSSYYYEPLPLPPEEVDPLPDKIKDEMKADTPSSDQSPAPSTGSKKKQGTRKRKPKATAASQAQQNQPQQPVLPGNMVGQGAGVNRFDRPQLNSSKQALTQMLSKRSMNPGHPGSFMTQPQPQRNPQAQFMRGTLRPGLPGNPGIGGNQVGMGPMNPAMAGGSTGIGAGAGGPVMGGQAMNAGGMIGAQQGGQVQAGGAGIMNQNAAAMMGSAGGSLMGQSGGSMIQGGMLNPQQNPAMVGQGMGAGGGIGAGSGMGGGTGGMGGAAGAMNSGGGMVAAGGMVNAAMGNTGIGTSAMGGGQGGMGGNSGMANAGGMGNPAMSNPGMGMQNMQQAGGNMQGAMFQGQNVPYQNVNQNYPSYGNQGMGQQGSQGGGMMGNFNQMAQQQRNTQAEFLAQQRAVMAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGANIPQTQQQFQQQQRLRLMMQQQQQQAGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNSMMGQQYPHQPPQY
Length2404
PositionKinase
OrganismAnopheles sinensis (Mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.06
Grand average of hydropathy-0.444
Instability index45.96
Isoelectric point6.84
Molecular weight260703.01
Publications
PubMed=24438588

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01311
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     341.02|      29|      29|    2133|    2161|       1
---------------------------------------------------------------------------
 2022- 2048 (43.86/14.18)	P..........GLP..GNPGIGG......NQVGMG...PM.NPA.....MAG.GS
 2054- 2078 (34.15/ 9.40)	...........GAG...GPVMGG......QAMNAG...GMIGA......QQ.GGQ
 2079- 2102 (27.90/ 6.32)	V..........QAG..GAGIMNQ......NAAAMM...GSA..........GGSL
 2103- 2129 (43.16/13.84)	M..........GQS..GGSMIQG......GM..LN...PQQNPA.....MVGQGM
 2133- 2161 (59.39/21.83)	G..........GIG..AGSGMGG......GTGGMG...GAAGAM.....NSGGGM
 2165- 2195 (34.59/ 9.62)	GgmvnaamgntGIG..T.SAMGG......GQGGMG...G..........NS..GM
 2199- 2227 (35.60/10.11)	G..........GMGnpAMSNPGM......GMQNMQ...QAGGNM.....Q..GAM
 2246- 2278 (32.87/ 8.77)	G..........NQG..MGQQ.GS......QGGGMM...GNFNQMaqqqrNTQAEF
 2283- 2320 (29.51/ 7.11)	R..........AVM..AGRGQYGqhapnvTMGNMGvnqGAVPPY.....PRQGGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.80|      28|      29|     215|     242|       2
---------------------------------------------------------------------------
  215-  242 (48.83/22.10)	GGMTGASSALGMSSAAGGANP..STIPPPL
  247-  273 (44.38/19.27)	GSM...HSPAGGNTGVGSMHPqqQQQPPPL
 2352- 2378 (43.59/18.77)	.GMGQGGNAQGMMQNQGQGMS..TQQTPNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.22|      22|      24|     379|     400|       3
---------------------------------------------------------------------------
  379-  400 (39.42/23.35)	P..DAEPGGKSSM.DTQEGKDKSLE
  402-  426 (31.80/17.11)	PskDGAVGGTPVQgDTKPTKANPFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.93|      28|      36|     818|     845|       4
---------------------------------------------------------------------------
  818-  845 (49.12/31.05)	DAPDSPKDPEQATPSVAGLGKAESSSRH
  857-  884 (51.81/33.21)	DDPISQHDCNQRYILLYGVGKERDEKKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.89|      15|      24|     668|     682|       5
---------------------------------------------------------------------------
  668-  682 (26.86/16.82)	LNNSDDKDS.VLSGSG
  694-  709 (23.03/13.27)	LMNFLDNDApVLDESG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.15|      26|      28|    1347|    1374|       6
---------------------------------------------------------------------------
  756-  776 (33.12/12.62)	...LGTGPIS..NKPT.TTSSPHNATG
 1347- 1373 (46.05/31.88)	SSIFGTGKRSGLNTPVhPGSTPKSMAG
 1378- 1396 (28.98/12.51)	SHILGTSDLSVLGNP......DESM..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.63|      20|      27|    1699|    1724|       7
---------------------------------------------------------------------------
 1699- 1722 (25.70/40.51)	GLFDaIMKNA...TSTTDwaiLFAQLI
 1725- 1747 (28.93/16.15)	GVID.LSNNSelfTTTLD...MLATLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.10|      27|      27|    1895|    1921|       8
---------------------------------------------------------------------------
 1866- 1893 (23.86/ 9.79)	PLAYEETHRL.......LKYHThslfkPSSyyyEP
 1895- 1921 (48.89/28.08)	PLPPEEVDPLPDKIKDEMKADT.....PSS...DQ
 1923- 1952 (36.35/18.92)	PAPSTGSKKKQGTRKRKPKATA.....ASQaqqNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.72|      22|      27|     514|     540|       9
---------------------------------------------------------------------------
  519-  540 (40.99/41.10)	HAESRWCIDKWQTAAGNASL..KI
  545-  568 (34.73/19.67)	DALDGHCFDRMDSNNSLDSLysKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.30|      22|      27|    1581|    1602|      10
---------------------------------------------------------------------------
 1581- 1602 (38.64/22.84)	ESTSMFSKNKDGNGGNSSSNNN
 1609- 1630 (36.66/21.21)	NSNSSVSSNGSTFGSKQSAQLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.14|      20|      36|    1178|    1198|      12
---------------------------------------------------------------------------
 1178- 1198 (34.17/24.96)	TACCNSLSTeWLGVLIA.LCGS
 1217- 1237 (31.97/18.37)	TNIHNALSV.FTSILVArHCFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.49|      10|      27|    1974|    1983|      14
---------------------------------------------------------------------------
 1974- 1983 (17.47/ 8.89)	RPQLNSSKQA
 2004- 2013 (20.03/11.57)	QPQPQRNPQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.58|      31|     486|     121|     151|      15
---------------------------------------------------------------------------
  121-  151 (56.70/36.98)	AKKAPSFNKKEE..IFAMLCENQVTMQR........AAWFI
  608-  648 (45.88/28.52)	ATKQFEYNVEQDasIVKILCEWAVSWQRwgehramvVAWLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.92|      20|      34|    1085|    1106|      20
---------------------------------------------------------------------------
 1085- 1106 (32.10/27.92)	PQ......QEPFHNAypKIKQALYTPLQ
 1116- 1141 (30.82/18.09)	PQfmidiiTNPRRGG..KIESAWARQLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.54|       9|      23|    1664|    1675|      34
---------------------------------------------------------------------------
 1664- 1675 (11.42/14.57)	LQNRdqsLEMVG
 1690- 1698 (16.12/ 8.32)	LQLR...YSLVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01311 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGLGTGPISNKPTTTSSPHNATGMDEDVLQTDF
2) DLDKLLQHIKEDQQNSMDAPDSPKDPEQATPSVAGL
3) HEHYHQGPLQEKPSSGGSGGSGGMTGASSALGMSSAAGGANPSTIPPPLSSPAGSMHSPAGGNTGVGSMHPQQQQQPPPLSPQEEQRIA
4) LPLPPEEVDPLPDKIKDEMKADTPSSDQSPAPSTGSKKKQGTRKRKPKATAASQAQQNQPQQPVLPGNMVGQGAGVNRFDRPQLNSSKQALTQMLSKRSMNPGHPGSFMTQPQPQRNPQAQFMRGTLRPGLPGNPGIGGNQVGMGPMNPAMAGGSTGIGAGAGGPV
5) MFSKNKDGNGGNSSSNNNSHSHGANSNSSVSSN
6) MNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKH
7) NINLASPDAEPGGKSSMDTQEGKDKSLEKPSKDGAVGGTPVQGDTKPT
8) NSGMANAGGMGNPAMSNPGMGMQNMQQAGGNMQGAMFQG
9) NVNQNYPSYGNQGMGQQGSQGGGMMGNFNQMAQQQRNTQAEFLAQQRAVMAGRGQYGQHAPNVTMGNMGVNQGAVPPYPRQGGKPGVGANIPQTQQQFQQQQRLRLMMQQQQQQAGMGQGGNAQGMMQNQGQGMSTQQTPNLVAQLQRQMPNQNSMMGQQYPHQPPQY
10) PAESVSNSGSGKGMQSGGQQSGATDGKDAATK
754
801
194
1894
1585
1
373
2192
2237
579
786
836
282
2059
1617
35
420
2230
2404
610










Molecular Recognition Features






MoRF SequenceStartStop




1) MNMRPLKRPRLG
1
12