<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01295

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMAATEMPLMLDNSLPVDLDDVDDLFGDGVDLTLPVRSQRKVLRHRLDELKNNGCCQAVAWSKTGTIASITTDGQNIELRYLRCSPENGSWDLSEPTICSHVKGTAAAPLVHLEWSPTSSPDLAIFDAVGRVAIVTFSQYLNQPFVTKKWDADPVDDIHLVAGCHWLAVAPANQQKPYNVLYGPATKHGNSYHYDSSFVHATGPNHPSASKSALFCVTSSGMLKMFWSQFNNKTEETTMELESVNSSDDLVTHAALASDKRFLLLAIVTSSLQMSLVKIEIHWAGAGTQLDKNNPIPQNVRLNPSLVERHLATTSWLQSGLGDAGPGTSPAELTHLQVLPSLIDQTGKNMVPPMIIAIRSRASLPGSDDLVQSIIERWEAIEQRQSLHPAFEQLGSRGSSISSEKPNATHLRRLDPIVVDKVVVGFQTVQFGKVAILTFADGTVQFRDRFTFEELYATPNLTKVSNLHQAGWTYTDNGPCKSPPRAQLPHIASLAITTAASTWHQCNYDDMLGIVQPYAKKKKFTQDWITELTRVLKIQVDYSEELHHESLMRNAPLQSCLSIMNSLGFQGELHPRLFQSKFALLDLNLRNVGILITLASNTPVTIKEKMSPLDEPEVVEALAGCAKWSLDLMAWLINCLYDLARDDEFTEKLIPQRFSEAAQYLRARNDVSLHLMLSSSSRGFLLATCRRIMHLEVLSARAIEFYRRHSYVAEASMPGKAPNPQLQQAYQKMQQTIASGLIRVGEFEKLLTVVGNDVRQAYSEFLPSLIKQQPNAPQGKQLDAAVKSAQIQMELSLLVAASPPPPFLPVIKKFFNKELPGFRKQTDPANLFYANYDLLQVDDDKRSKADKGFYVDVFKKEEIHPKSILQWRRCTRCAAVMEDVYGTRPGFIFVLGQQRKCSCGGYWGLLPKGKLLL
Length916
PositionTail
OrganismStachybotrys chartarum IBT 40288
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.08
Grand average of hydropathy-0.209
Instability index50.06
Isoelectric point6.80
Molecular weight101993.59
Publications
PubMed=25015739

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01295
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.49|      80|     119|     164|     250|       1
---------------------------------------------------------------------------
  164-  250 (131.90/80.12)	HWLAVAPA...NQQKPYNVLYGPA..TKHGNSyhydSSFVHAT.GPNHPSASKSALfcvTSSGMLKMFWSQF.NNKTEETTMELESVNS...SDDLV
  281-  370 (118.59/58.05)	HWAGAGTQldkNNPIPQNVRLNPSlvERHLAT....TSWLQSGlGDAGPGTSPAEL...THLQVLPSLIDQTgKNMVPPMIIAIRSRASlpgSDDLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.56|      29|     314|     125|     162|       2
---------------------------------------------------------------------------
  125-  153 (53.44/26.89)	FDAV..GRVAIVT.........FS....QYLN..QPFVTKKWDADP
  425-  458 (36.72/14.62)	FQTVqfGKVAILT.........FAdgtvQF.R..DRFTFEELYATP
  487-  521 (20.41/11.41)	LPHI..ASLAITTaastwhqcnYD....DMLGivQPYAKKK.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.26|      22|     314|     543|     564|       3
---------------------------------------------------------------------------
  543-  564 (39.14/24.56)	EELHHESLMRNAPLQSCLSIMN
  860-  881 (41.12/26.14)	EEIHPKSILQWRRCTRCAAVME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.01|      14|     365|     404|     417|       7
---------------------------------------------------------------------------
  404-  417 (25.63/15.92)	KPNATHLRRLDPIV
  772-  785 (25.38/15.70)	QPNAPQGKQLDAAV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01295 with Med16 domain of Kingdom Fungi
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