<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01290

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMQSASLSLSFVGITVLDTTGMSAGETDSMAGQHGSQLSNGQGSQTQPDGIFHITDGFIPLSLLLTRLAQTTHNALQAKMVELAKMPLPAAAMNGNTAHANSADDVSSDNLRKKTALLNFAQDMHAKWVKVLVIADWSRKAESVSKLIDLKFHIDQQRILFDAALDNIVNIKRDLTYARMPSPDLKTALQVLSTGRAPWIPDLQYIPLPQLTADEQVKWMNDLDTLLSIRLNLEDYDKIPQQFKNYDISSGRVTFKVPGEFEVDLTIADEDFEKQFWFIDFRFAFSPAAQSLPESLRIYLEGCVNDALARDGLTGCYQFLHEYVLTMKIHELRRQAIQLSKTSWTGTLMVEPLHRALAIQYWTPRTAVTKSKSWVLVAINSGRKQNTPADAKAASYLVAKWYRDGKEVKDVEIPLDADNLSAESLLKTVVGRHVESILTSIHDKLLTAPRFQNREAGLKLRISKDDPTASSLKTQVGYRNSAALLIEPSTGAFAIKPHSKFVINYERQLNNGKTPIDDGVMCLEQVRCAMLEDELNRRGSCMGWVIRKAPITNEELHAVTKTRGPMRVLWLQKNGWRSNWFVAIILSLAGDQWWLLETSDTRAVPFYARLPLRKGHPDLTDKFWDNLTLFSTGMLAQSVDMRELHRRSIKSRPNETVVWSLPQQVRLPALEVALSAIYPAMLFDSAETESDPPSADQTALAATISSILRTTHANRHPASQPWAFDLVTIKFRGVEVQPVRTESSGHGTLQCLSDAFIKVRKPARYATLSGSIDRDISYNSRRGEFCLRLRHVAGQSLIDVLETKVKAIDRFVTFLDALDRAKDTIECGKVTLREVTFFYGSDKSSAGHEGEQPQKWRVVLDLSEKDIDVQFEQGNPHLRVVDLAKTLVNAADGINGLLHWLPTSLPTFRTIDDIQSRWEDFQAQNRGQVDFIVKTMDWMRIHYDIAQGASTGASDRRHLVLEMQCRLRRDEPWWHIRRSAEILVAGVPVRSDDFTNALDPIWQGRGDGWHGLASGASGRHGEGVAALLQVVDNAIYTVATASWAVEPDGTGNAPLVVVD
Length1058
PositionTail
OrganismStachybotrys chartarum IBT 40288
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.08
Grand average of hydropathy-0.261
Instability index38.53
Isoelectric point6.55
Molecular weight118374.38
Publications
PubMed=25015739

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01290
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     368.66|     116|     377|     496|     624|       1
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  496-  624 (179.50/156.85)	PHSKfVINYERQLNNGKTPIDdGVMCLEQVRCAMLE..DELNRRgscmgWVIRKAPiTNEELHAVTKTRGPMRVLWLQKNGW......RSNWFVAIILSLAGDQ.WWLLETSDTRAVpfyARLPLRKGhpDLT...DKFWD
  875- 1002 (189.16/122.48)	PHLR.VVDLAKTLVNAADGIN.GLLHWLPTSLPTFRtiDDIQSR.....WEDFQAQ.NRGQVDFIVKTMDWMRIHYDIAQGAstgasdRRHLVLEMQCRLRRDEpWWHIRRSAEILV...AGVPVRSD..DFTnalDPIWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.96|      10|      15|     174|     183|       2
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  174-  183 (20.19/12.86)	LTYARMP.SPD
  191-  201 (14.77/ 7.23)	LSTGRAPwIPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.67|      78|     670|      22|     106|      10
---------------------------------------------------------------------------
   22-  106 (123.24/94.81)	SAGETdSMAGQHGSQLSNGQGSQ...TQPDGIFHITDGFIPLSLLLTRLAQTTHNALQAKMVELAKMPLPA..AAMNGntahanSAD.DVS
  693-  776 (117.43/74.18)	SADQT.ALAATISSILRTTHANRhpaSQPWAFDLVTIKFRGVEVQPVRTESSGHGTLQCLSDAFIKVRKPAryATLSG......SIDrDIS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01290 with Med14 domain of Kingdom Fungi
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