<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01285

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGPNPAQKALQSATHQWLDFKAKCLATRLEPEKFEEFVPLIHSRYPLPPVAVADIFLRPPPSRTYSVDPRIPIYIQILSRLGYIDAPSLLNAVYNYSSSHAQLQSDHASGADGADTAKPKQPVRYTNAFWAEEVFFYHVIKTIVEGTAFRDSLAPVHMAKVVAKWMTLFAQASTAFAAVMLGDMQHSDARNQMEISKGAFVPLLLRLVDSPDFVRAISKPDAKDARRELHASLSSFIPSLQPAPQFVEKLEVFRTETLAQLDPPDKKSQAAEAAMDELLESAVGSDNLVIPEIPITNTRAGLYIYLNASLVARPILDDRMLFSYLNNRLGGDAQASAIDLILASFDALANAVFRTERLKDAHLFRSYLINKVPLLLCQLCPPGFANTSAELCITMALNQVDTGTFPTASLMFDESRQNNPYTESVREEFCAACALHGLIQREHVERILGEISMSYEPSLEKYSKDKLVQDCLSDPSKMQALVRELDKMDGNVGAVCQALVELMRHLCHNRETMSLKLLCGQLVQKPLSLDVLLLFERLPTVLEPLCQLLDNWHYDEDQGEYQPVYEEFGAIMLLVLAFAYRYKLSGADMGIQPPDSRVAQIISRAHVSRQIQDLTEQESQHLGGWVHGLFDSEAGGLGDDLMSSCPPQDFYLLIATLFQNIVVAYGDGYLTDESLKSGIEYLVDTFLLPSLVPAITFLSEYLWIDQKEQKSIIKILQLILLPTSISGEASTMLSSVKNLVAKPLENALRTYQRRDPKNQDIEPLLQALKESLPLSRRTGSAEFNELETWSSNSNNPNSPGFVGTIRHQIQTLVQWSLHPEVNYTPPTYTHRQMIAARQLMGPRRALRAILEETRAQTEAGNASIVYDIATALICAPDVTNDAPAPTGLLDTSGSMQGRRLSLRDVLKLLAEEYKKVQKQDGTLSEIIVRLHRRVEAQMVMPAPPAIMQNTDLLGGNAGTMGEGLASGPGAQADGMAVDNVMGMDGLGTDLGLGGPSGSGAGLDSGGDNDLFDLDASMDVFDGWDSNMDLT
Length1031
PositionTail
OrganismStachybotrys chartarum IBT 40288
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.07
Grand average of hydropathy-0.131
Instability index42.12
Isoelectric point4.98
Molecular weight113675.43
Publications
PubMed=25015739

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01285
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     566.74|     163|     373|     408|     573|       1
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  408-  555 (243.32/187.91)	.............................................................TASL......MFDE.....SRQNNP....YTESVREEFCAACA...LHGLIQ.REHVERILGEISMSYEP......SLEKYSKDKLVQDCLSDPSKMQALVRELD..........KMD..GNVGAVCQALVELM.RHLC.......HNRETM..SLKLL..CGQLVQKPLSL.DVL.LLFERL.PTV..LE...PLCQLLDNWHY
  559-  769 (144.32/112.78)	QGEYQPVYEEFGAIMllvlafayryklsgadmgiqppdsrvaqiisrahvsrqiqdlteqeSQHLggwvhgLFD......SE.........AGGLGDDLMSSCPpqdFYLLIA......TLFQNIVVAYGDgyltdeSL.KSGIEYLV.DTFLLPS....LVPAITflseylwidqKEQ..KSIIKILQ.LILLP.TSIS.......GEASTMlsSVK......NLVAKPLE..NAL.RTYQRRdPKNqdIE...PLLQAL.....
  780-  933 (151.96/113.43)	..............................................................GSA......EFNEletwsSNSNNPnspgFVGTIRHQ.........IQTLVQwSLHPE.......VNYTP......PTYTHRQMIAARQLMGPRRALRAILEETR..........AQTeaGNASIVYDIATALIcAPDV.......TNDAPA..PTGLLdtSGSMQGRRLSLrDVLkLLAEEY.KKV..QKqdgTLSEIIVRLHR
  934-  968 (27.14/ 8.41)	RVEAQMVMPAPPAIM.........................................................................................................................................................................................qntdllgGNAGTM..GEGLA..SG..........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     133.30|      60|     161|      38|     112|       2
---------------------------------------------------------------------------
   45-   77 (35.22/36.66)	.............................................................................................................................................................................................................................................................................................................................................................................................RYPLppvAVADIFLRPPPSRTYSVDPRIPIYIQ
   78-  110 (26.33/23.35)	ILSRLgyIDAPSLLNAVYNYSSSHAQlQSDHAS.............................................................................................................................................................................................................................................................................................................................................................................................
  204-  233 (34.00/13.85)	LLLRL..VDSPDFVRAISKPDAKDAR.RELHAS.............................................................................................................................................................................................................................................................................................................................................................................................
  582-  611 (37.75/16.72)	.................................lssfipslqpapqfveklevfrtetlaqldppdkksqaaeaamdellesavgsdnlvipeipitntraglyiylnaslvarpilddrmlfsylnnrlggdaqasaidlilasfdalanavfrterlkdahlfrsylinkvplllcqlcppgfantsaelcitmalnqvdtgtfptaslmfdesrqnnpytesvreefcaacalhgliqrehverilgeismsyepslekyskdklvqdclsdpskmqalvreldkmdgnvgavcqalvelmrhlchnretmslkllcgqlvqkplsldvlllferlptvleplcqlldnwhydedqgeyqpvyeefgaimllvlafayRYKL...SGADMGIQPPDSRVAQIISRAHVSRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.21|      22|      40|     308|     329|       3
---------------------------------------------------------------------------
  308-  329 (37.80/24.51)	NASLVARPILDDRMLFSYLNNR
  351-  372 (37.41/24.18)	NAVFRTERLKDAHLFRSYLINK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.10|      24|      34|     970|     993|       5
---------------------------------------------------------------------------
  970-  993 (41.75/23.52)	GAQADGMAVDNVMGM.DGLGTDLGL
 1006- 1030 (39.36/21.76)	GGDNDLFDLDASMDVfDGWDSNMDL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01285 with Med5 domain of Kingdom Fungi
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