Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MAGLELKDDELKALEQLLARVAQLSNSIQSLKTDILKSNPLPSHSSLQASAQILQRNLQTVLDCMNENKDLFNRTAIHPSTNYPGRTQENILLQLVRKKVEPNVEELLSQAREAADAVGPEGIANLQKLWEELREWTHGRIAEYVREEAGDVYTKEERDIGVENVRTGLRKNLDDDDEDEEFEDDEDTKMEQDLGQAPQQPPLQSSRARGPELETLLWFAARGDFELPPNIEYERKVDVYKGFQGVRIPEPRPQEFPS |
Length | 258 |
Position | Head |
Organism | Stachybotrys chartarum IBT 40288 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.817 |
Instability index | 55.89 |
Isoelectric point | 4.62 |
Molecular weight | 29415.37 |
Publications | PubMed=25015739 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP01283 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 155.66| 50| 88| 99| 153| 1 --------------------------------------------------------------------------- 99- 153 (73.34/61.05) KVEPNVEELLSQAR.EAADAVGPEgIANLqkLWEELR.EWTHGRIAEYVREeaGDVY 189- 240 (82.32/51.29) KMEQDLGQAPQQPPlQSSRARGPE.LETL..LWFAARgDFELPPNIEYERK..VDVY --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.97| 15| 27| 24| 50| 3 --------------------------------------------------------------------------- 24- 39 (18.80/35.11) LSNSIQSLkTDILKSN 54- 68 (26.16/ 9.55) LQRNLQTV.LDCMNEN --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GPELETLLWFAAR 2) PNIEYERKVDVYKGFQGVRIPEPRP | 210 229 | 222 253 |
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