<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01283

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMAGLELKDDELKALEQLLARVAQLSNSIQSLKTDILKSNPLPSHSSLQASAQILQRNLQTVLDCMNENKDLFNRTAIHPSTNYPGRTQENILLQLVRKKVEPNVEELLSQAREAADAVGPEGIANLQKLWEELREWTHGRIAEYVREEAGDVYTKEERDIGVENVRTGLRKNLDDDDEDEEFEDDEDTKMEQDLGQAPQQPPLQSSRARGPELETLLWFAARGDFELPPNIEYERKVDVYKGFQGVRIPEPRPQEFPS
Length258
PositionHead
OrganismStachybotrys chartarum IBT 40288
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.05
Grand average of hydropathy-0.817
Instability index55.89
Isoelectric point4.62
Molecular weight29415.37
Publications
PubMed=25015739

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01283
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.66|      50|      88|      99|     153|       1
---------------------------------------------------------------------------
   99-  153 (73.34/61.05)	KVEPNVEELLSQAR.EAADAVGPEgIANLqkLWEELR.EWTHGRIAEYVREeaGDVY
  189-  240 (82.32/51.29)	KMEQDLGQAPQQPPlQSSRARGPE.LETL..LWFAARgDFELPPNIEYERK..VDVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.97|      15|      27|      24|      50|       3
---------------------------------------------------------------------------
   24-   39 (18.80/35.11)	LSNSIQSLkTDILKSN
   54-   68 (26.16/ 9.55)	LQRNLQTV.LDCMNEN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01283 with Med8 domain of Kingdom Fungi
Unable to open file!