<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01282

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEAGEYETNTLLINDIASIHFHVYEPSPEQSQAFPSAAIELESALRDRGYIVIYDPNRRALWRYSITTKHDKIGPHEATPDATINVAGWTLTLTEDGSLEPSSLHKGRTFVGTSAYTPTSSSSSGSALEPHQRAAFLSPSQPSGIGQLELEPKVTGLNGNDSKAVQGMQKAIYENFIAAVLLTVSTSFCRRVGALPLNYRTVLLPQDEISNWSSDGQSSELDPVLGAFRLYLTTTGALVFSLSFHQCSGLLNLGSVVAASLTSTSQPIIAAPFGVLAHRQRSNAGEIGLASLAQTPNTQTLSLRAGRDTADSFWKQACLKFLRCRGVEPSPLSDCPWVSLLVSKKRFQDNKGDTKRSQHSSPSASIPWPGPLCFRKRTIDVSTTSLVGDTMLSSHEESHDPLGYASAWLASAADRDEKLQKRKSHRASTARKELSDRPPEAPKTAALSPLDVRRPNTNVAMGAMYPTPPDGIQQLNGITPSLDGTISSPGNMVPTATVVDVDTTAQPSGIEETFNHATEFSEPKRERSDSNLLGDGENVFTDMDGDMFGENDITEADFNFFDEQPGDEDLDISLGDLEAMVDAQQPPTSMKSEQEPQPAMDETIIPLPPIQNDAVFTKPELRHARSSLIDEGKRSNRAERSGPLKRDPSPFDTHTVLKRVRASLQLPNPDSENKNSVFAKVDFGSALPVINRKYERGGFFDYNRSPRIDKPKIEPGALPQTDYLKRHAKHSRKMRDHQLPVETLVKGGGLATGTPMQLSPIGADAPLSDVEDSSEASDQDDSSYTTDEPGSPLKSSIKPTSIEDDVLSQGTSFRDMEPVEEIDHHLAVELPRLVKPEAPEIPLAKLFADAEPLPVDLSLSDEDLVQIGQLLADQAATGYLQIRKVQKTVATGSMPTQKGRSLAIGTRGLMHVLEDIMLDLLGPTHACRLKGLLDVQDVPLLGQPSRLQPRPIPGRDPNAEQLRLNNLYQIWAPQLEVRRAETRMTVLPSAINFWESLGLAPSSGNKNVLAIGIFPGWRGVAENVGVFLERMKNVYELLKMGSFENAPLPAEFCDGLMPYELEKISTSPDATLTSHGSALVEIIDTLKATLMNLDASEKNVVVYFVYSPTHPATIVESCVAFQRLFESYQKTLAGRREAPVNELVLQLIPVDILSSSNGVVVTTPPELAKLCVETYDRCTLFNGPMPAPAVKLAQALPRHIDFKLVHQPSASLLHENSCIHIAYTQSVDDRWVSAAWTDDRGNQQATAAYCLARRGKPLSLSMHDIAHEIWKTTLDLISVWKVHWRVVITKCSPMDSQEIDFWLDLARTEIKANVTMTLMTVDTAPSLQLIPPLIRTPATNVSFYSTPVSTPQANIVSPEQSGTPMTPARDSAAASAATPGADGTPDAEADAVLVDVTEQTWGAVVGHRLSNSTTILDLQPALASGYLIKRASNRVEDAPVVMEVNLIHAAASNRPYEWVLREMLSNFRGLGTLARARGMVDRETDVRPWHVAAAEKALRALYLLL
Length1505
PositionKinase
OrganismStachybotrys chartarum IBT 40288
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.06
Grand average of hydropathy-0.308
Instability index45.89
Isoelectric point5.31
Molecular weight164291.67
Publications
PubMed=25015739

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01282
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     395.19|     112|     117|     632|     748|       1
---------------------------------------------------------------------------
  453-  529 (102.92/52.30)	RRPNTNVAMGAM..YPTPPDGIQQLNGITPSLDgtISSPGNMVPTATVVDVDTTAQPSGIEETFNHATEFSEPKRERSD............................................
  633-  746 (183.15/118.29)	KRSNRAERSGPLKRDPSPFDTHTVLKRVRASLQ..LPNPDSENKNSVFAKVDFGSALPVINRKYERGGFFDYNRSPRIDKPKIEPGALpQTDYLKRHAKHsRKMR.....DHQLPVE..TLVK
  753-  835 (109.12/56.65)	........GTPMQL..SPIGADAPLSDVEDSSE..ASDQDDSSYTT........................DEPGSPL..KSSIKPTSI.EDDVLSQGTSF.RDMEpveeiDHHLAVElpRLVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.26|      42|     297|     946|    1008|       3
---------------------------------------------------------------------------
  266-  315 (55.82/20.97)	QPiiaAPfgvLAHRqRSNAGEIGLASLAQTPNTQtLSLRAG..R....DTADSFWK
  948-  995 (70.44/72.95)	QP...RP...IPGR.DPNAEQLRLNNLYQIWAPQ.LEVRRAetRmtvlPSAINFWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.40|      14|     301|     567|     588|       4
---------------------------------------------------------------------------
  552-  565 (25.94/15.94)	DITEADFN.FFDEQP
  571-  585 (19.46/14.27)	DISLGDLEaMVDAQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.49|      47|     179|    1145|    1195|       7
---------------------------------------------------------------------------
 1145- 1195 (72.10/61.98)	LQLIPVDILSSSNGV.VVTTPPELAKLCVETYDRCtlfNGPMpAPAVKLAQA
 1327- 1374 (78.38/52.86)	LQLIPPLIRTPATNVsFYSTPVSTPQANIVSPEQS...GTPM.TPARDSAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.92|      19|     713|     367|     395|       8
---------------------------------------------------------------------------
  341-  359 (34.49/23.59)	LVSKKRFQDNK.....GDTKRSQH
  372-  395 (29.44/20.57)	LCFRKRTIDVSttslvGDTMLSSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.42|      14|      21|    1035|    1048|      12
---------------------------------------------------------------------------
 1035- 1048 (25.40/15.70)	YELLKMGSFENAPL
 1059- 1072 (24.03/14.42)	YELEKISTSPDATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.97|      14|      20|     899|     912|      13
---------------------------------------------------------------------------
  899-  912 (24.91/15.57)	GRSLAIGTRGLMHV
  922-  935 (26.06/16.65)	GPTHACRLKGLLDV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01282 with Med13 domain of Kingdom Fungi
Unable to open file!