<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01274
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MAGLELKDDELKALEQLLARVAQLSNSIQSLKTDILKSNPLPSHSSLQASAQILQRNLQTVLDCMNENKDLFNRTAIHPSTNYPGRTQENILLQLVRKKVEPNVEELLSRAREAAEAVGPEGIANLQRLWEELREWTHGRIAEYVREEAGDVYTKEERDMGVENVRTGLRKNLDDEDEDEDEEFEDDEDTKMEQDPGQTSQQFPLQPSRARGPELETLLWFAARGDFELPPNIEYERKADVYKGFQGVRIPEPRPQEFPS |
Length | 260 |
Position | Head |
Organism | Stachybotrys chlorohalonata (strain IBT 40285) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.877 |
Instability index | 55.53 |
Isoelectric point | 4.62 |
Molecular weight | 29797.73 |
Publications | PubMed=25015739
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP01274
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 164.90| 50| 109| 58| 108| 1
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58- 108 (82.02/54.93) LQTVLDCMNENKD.LFNRTAIHPSTNYPGRTQENILLQLVRKKvEPNVEELL
169- 219 (82.88/51.39) LRKNLDDEDEDEDeEFEDDEDTKMEQDPGQTSQQFPLQPSRAR.GPELETLL
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