<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01273

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTADDGPPLSLRPFPVANQKPKTLAEFIARVNAQPGGFRATTKEKLEEEICANQSKDGADDVEDMQMSDGEGDDSASNEGEPESSIKDPNQARMEVLRDMDIMGNTAMLTLDFLSLLLSKYNPTHASQTLSQQLRDMVGIGTIGADKLYESSMTEEKAKNQAEVAAGWTLMETNKTRDAAEEATAFLEKEMEAEGKYWDDVVSVQKAGWSVCRMPNERHTLGVRFGFSEAAPEFRTNSLAPLRRADDGSVQLDSGRLGGVSERLLVTYEKDGQVVSRSSLPPPISDDAPLEARVLEARNTIYSQELWHELTRESRTLVAYDVRLEGSRLTCEVDSSTRIIVELVPLETSRAADEQPRDGLVAEAISLALHILLGHAHRTNELVRTRPIPPYVSRPKGQQIHVLLRPIIARTMHDRDIRETTKYVGSLVQALQKAGLPASLVLSTPQVAISDGSNRGPNQTSSAQTLVRTMLQPLDFTLAVTILPTVSFTVQGRTHLSPVTATYYHITLPPESPLEHICKPYHDVYPDLQALVDYLNTATARVLSEHILSKLMAAGSTADWTQDVKGTSIRNLDRQDFDLGFAIDKQDDKPALIVRHASEEGQKRSVKKWTWAAAGDSEGSSLHHVVGQIVGQDLSDGAM
Length639
PositionHead
OrganismStachybotrys chlorohalonata (strain IBT 40285)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.05
Grand average of hydropathy-0.415
Instability index41.30
Isoelectric point5.15
Molecular weight70252.19
Publications
PubMed=25015739

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01273
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     280.76|      92|     106|     239|     337|       1
---------------------------------------------------------------------------
  239-  337 (140.38/87.47)	LAPLR..RADDgsvqlDSGRLGGVSER.......LLVTYEKDGQVVSRSSLPPPISDDAPLEARVLeARnTIYSQELWHELTRESRTLVAYDVR.LEGSRLTCEVDSST
  343-  444 (140.38/72.31)	LVPLEtsRAAD.....EQPRDGLVAEAislalhiLLGHAHRTNELVRTRPIPPYVSRPKGQQIHVL.LR.PIIARTMHDRDIRETTKYVGSLVQaLQKAGLPASLVLST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.62|      13|      35|      88|     100|       2
---------------------------------------------------------------------------
   88-  100 (24.53/16.92)	DPNQARMEV...LRDM
  122-  137 (19.09/11.51)	NPTHASQTLsqqLRDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.08|      27|      39|     166|     192|       5
---------------------------------------------------------------------------
  166-  192 (45.20/34.76)	AGWTLMETNKTRDAAEEATAFLEKEME
  207-  233 (49.88/39.19)	AGWSVCRMPNERHTLGVRFGFSEAAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.79|      52|     577|       4|      59|       6
---------------------------------------------------------------------------
    4-   59 (79.25/46.06)	DDGPPLSLRPFPVANQKpKTLAEFiarVNAQPGGFRATTKEKLEEEICANQSKDGA
  587-  638 (88.54/41.82)	DDKPALIVRHASEEGQK.RSVKKW...TWAAAGDSEGSSLHHVVGQIVGQDLSDGA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01273 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQPGGFRATTKEKLEEEICANQSKDGADDVEDMQMSDGEGDDSASNEGEPESSIKDPNQARMEVLRD
33
99










Molecular Recognition Features






MoRF SequenceStartStop




1) GFRATTKEKLEEEICA
2) KRSVKKWTWAA
3) PLSLRPFPVANQKPKTLAEFIARVNAQP
37
603
8
52
613
35