<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01271

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWGQAIAQVHCGPPRVPIVKSANINDIASIHFHVYEPPLEHSQAFPSAAIELESALRDRGYIVIYDPNRRALWRYGITTKHDKTGPHEATPEATIHVAGWTLTLTEDGSLEPSSLHKSRTFVGTSAYTPTSSSSSGSALEQHQRAAFLSPSQPPSIGQLELEPKVTGLNGNDSKAVQGMHKAIYENFIAAVLLTVSTSFCRRVGALPLNYRTVLLPQDEISNRSSDGQLSESDPVLGTFRLYLTTTGALIVSLSFHQCSGLLNLGSVVAASLTSTSQPIIAAPFGVLAHRQRSNAGEIGLASLAQTPNTQTLSLRAGRDTADSFWKQACLKFLRCRGVEPSTLSDCPWVSLLVSKKRFQDNKCDTKRSQHSSPSASIPWPGPLCFRKRTIDVSTTSLVGDTMLSSHEESHDPLGYASAWLASAADRDEKLQKRKSHRASAARKELSDRPPEAPKTAALSPLDVRRPNTNVAIGAMYPTPPDGIQQLNGITPSLDGTISSPGNMVPTATVVDVDATAQPSGTEETFNHTTEFSEPKRERSDSNLLGDGENVFTDMDGDMFGENDITEADFNFFDEQPGDEDLDISLGDLEAMVDAQQPPTVMKSEQEPQPAMDENILPLPPIQNDAVFTKPELRHARSSLVDEGKRSNRAERSGPLKRDPSPFDTHTVLKRVRASLQPPNPDSENKNSVFAKVDFGSALPVINRKYERGGFFDYNRSPRIDKPKLEPGALPQTDYLKRHAKHSRKLRDHQLPVETLVKGGGLATGTPMQLSPIGPDAPLSDMEDSSEASDQDDSSYTTDEPGSPLKSSIKPTSIEDDVLSQGTSFRDMEPVEEIDHHLAVELPRLVKPEAPEIPLAKLFADAEPLPVDLSLSDEDLVQIGQLLADQAATGYLQIRKVQKTVATGSMPTQKGRSLVVGTRGLMHVLEDIMLDLLGPAHACRLKGLLDVQDVPFPGQPSRLQPRPIPGRDPNAEQLRLNNLYQIWAPQLEVRRAETRMTVLPSAINFWESLGLAPSSGNKNVLAICIFPGWRGVAENVGVFLERMKNVYELLKMGSFENAPLPAEFCDGLMPYELEKISTSPDATLTSHGSALVEIIDTLKATLINLEASEKNVVVYFVYSPTHPATIVESCVAFQRLFESYQKTLAGRREAPVNELVLQLIPVDILSSSNGVVVTTPPELAKLCVETYDRCTLFNGPMPAPAVKLAQALPRHIDFKLVNQPSASLLHENSCIHIAYTQSVDDRWVSAAWTDDRGNQQATAAYCLARRGKPLSLSMHEIAHEIWKTTLDLISVWKVHWRVVITKCSPMDSQEIDFWLDLARTEIKANVTMTLMTVDTAPSLQLIPPLIRTPATNVSFYSTPVSTPQANIVSPEQSGTPMTPMRDSAAASAATPGADGPPDAEADAVLVDVTEQTWGAVVGHRLSNSTTILDLQPVLASGYLIKRASNRIEDAPVVMEVNLIHAAASNRPYEWVLREMLSNFRGLGTLARARGMVDRETDVRPWHVAAAEKALRALYLLL
Length1516
PositionKinase
OrganismStachybotrys chlorohalonata (strain IBT 40285)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.06
Grand average of hydropathy-0.305
Instability index47.19
Isoelectric point5.51
Molecular weight165645.51
Publications
PubMed=25015739

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01271
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.87|      25|      29|     531|     558|       1
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  531-  558 (41.05/38.19)	FSEPKRERSDSNLLGD..GENvftDMD...GDM
  559-  588 (35.82/23.78)	FGENDITEADFNFFDEqpGDE...DLDislGDL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.90|      21|      29|     460|     488|       2
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  460-  480 (41.40/22.48)	P.LDVRRPNTNVAIGAMYPTPP
  491-  508 (27.25/25.17)	PsLD....GTISSPGNMVPTAT
  891-  907 (20.25/ 6.27)	..LQIRKVQKTVATGSM.PT..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.95|      25|      29|     336|     360|       3
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  336-  360 (45.46/27.89)	RGVEPSTLSDCPWVSLLVSKKRFQD
  367-  391 (48.49/30.32)	RSQHSSPSASIPWPGPLCFRKRTID
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.17|      56|      60|    1054|    1113|       4
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 1054- 1113 (83.68/52.21)	FENAPL.PAEFCDGLMPYelEKISTSPDATLTSHGSALV.EIIdtLKATLINLEASEKNVVV
 1115- 1172 (84.49/43.03)	FVYSPThPATIVESCVAF..QRLFESYQKTLAGRREAPVnELV..LQLIPVDILSSSNGVVV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     218.86|      52|      86|     712|     767|       5
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  660-  710 (42.18/18.25)	....SPfdthtvlkRV.RA.SL.QP...PNPDSENKNSVFAKVDFGSALPViNRKYERGGF........
  712-  764 (87.31/55.89)	DYNRSP........RIdKP.KL.EPGALPQTDYLKRHAKHSRKLRDHQLPV.ETLVKGGGL.....ATG
  798-  840 (44.33/19.61)	DEPGSP.....lksSI.KPtSI.EDDVLSQGTSF.RDMEPVEEI.DHHLAV.E................
  842-  889 (45.04/17.27)	..................P.RLvKPEA.PEIPLAKLFADAEPLPVDLSLSD.EDLVQIGQLladqaATG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     198.40|      63|     677|     256|     326|       7
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  256-  326 (90.57/74.01)	HQC..SGLLNLGSVVAASLTSTSQPiiaAPfgvLAHRQrSNAGEIGLASLAQTPNTQtLSLRAGR......DTADSFWK
  936- 1006 (107.83/63.19)	HACrlKGLLDVQDVPFPGQPSRLQP...RP...IPGRD.PNAEQLRLNNLYQIWAPQ.LEVRRAEtrmtvlPSAINFWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.85|      69|    1220|      73|     152|       9
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   73-  152 (98.78/81.89)	WRYgITTKHDKTGPHE.......ATPEATIHVagwTLTL.TEDGSlePsSLHksrtFVGTSAYTPTSSSSSGSALEQHQRAAFLSPSQ
 1295- 1371 (111.06/61.19)	WRV.VITKCSPMDSQEidfwldlARTEIKANV...TMTLmTVDTA..P.SLQ....LIPPLIRTPATNVSFYSTPVSTPQANIVSPEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.56|      14|      14|     411|     424|      12
---------------------------------------------------------------------------
  411-  424 (24.78/16.15)	DPLGYASAWLASAA
  428-  441 (22.78/14.20)	EKLQKRKSHRASAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.25|      26|    1179|      12|      38|      13
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   12-   38 (44.54/32.91)	GPPRVPIVKSANINDiASIHFHVYEPP
 1194- 1219 (47.71/30.59)	GPMPAPAVKLAQALP.RHIDFKLVNQP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.56|      13|     597|     765|     788|      14
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  765-  788 (14.04/32.80)	TPMqlspigpdAPlsdMEDSSEAS
 1374- 1386 (26.52/14.21)	TPM........TP...MRDSAAAS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01271 with Med13 domain of Kingdom Fungi
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