<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01269

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMLDNSLPVDLDDVDDLFGDGVDLTLPVRSQRKVLQHRLDELKNNGCCQAVAWSKTGTIASITTDGQNIELRYLRCSPENGSWDLSEPTICSHVKGTAAAPLVHLEWSATSSPDLAIFDAVGRVAIVTFSQYLNQPFVTKKWDADPVDDIHLVAGCHWLAVAPANQQKPYNVLYGPATKHGNSYHYDSSFVHATGPNHPSASKSALFCVTSSGMLKMFWSQFNNKTEETTMELESVNSSDDLVTHAALASDKRFLLLAIVTSSLQMSLVKIEIHWAGAGAQLDKNNPIPQNVRLNPSLVERHLATTSWLQSDLGDAGPSTSLAELTHLQVLPSLIDQTGKNMVPPIIMAIRSRASLPGSDDLAQSIIERWEAVEQRQSLHPAFEQLGSRGSSISSEKPNATHLRRLEPIVVDKVVIGFQTVQFGKVVILTFADGTVQFRDRFTFEELYATPNLTKCSMMQLGDDGKVRWSKLHFPNGDIGETMQDAHYAASIASLAITTAASTWHQCNYDDMLGIVQPYAKKKKFTQDWITELTRVLKIQVDYSEELHHESLMRNAPLQSCLSIMNSLGFQGELHPRLFQSKFALLDLNLRNVGILITLASNTPVTIKEKMSPLDEPEVVEALAGCAKWSLDLMAWLINCLYDLARDDEFMEKLVPQRFSEAAQYLRARNDVSLHLMLSSSSRGFLLATCRRIMHLEVMSARAIEFYRRHSYVAEASMPGKAPNPQLQQAYQKMQQTIASGLIRVGEFEKLLTVVGNDVRQAYSEFLPSLIKQQPNAPQGKQLDAAVKSAQIQMELSLLVAASPPPPFLPVIKKFFNKELPGFRRQTDPANLFYANYDLLQVDDDKRSKADKSFYVDVFKKEEIHPKSILQWRRCTRCAAVMEDVYGTRPGFIFVLGQQRKCSCGGYWGLLPKGKLLL
Length920
PositionTail
OrganismStachybotrys chlorohalonata (strain IBT 40285)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.08
Grand average of hydropathy-0.196
Instability index49.93
Isoelectric point6.43
Molecular weight102638.35
Publications
PubMed=25015739

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01269
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.26|      22|     316|     547|     568|       2
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  547-  568 (39.14/18.77)	EELHHESLMRNAPLQSCLSIMN
  864-  885 (41.12/19.99)	EEIHPKSILQWRRCTRCAAVME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.64|      26|      41|     611|     636|       3
---------------------------------------------------------------------------
  611-  636 (46.29/23.02)	EKMSPLDEPEVVEALAGCAKWSLDLM
  654-  679 (44.35/21.82)	EKLVPQRFSEAAQYLRARNDVSLHLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     273.40|      90|     379|      59|     155|       4
---------------------------------------------------------------------------
   59-  155 (141.76/113.35)	GTIASIT.TDGqNIELRYlRCSPENgSWDLSEPTICSHVK.GTAAaplvHLEWS..................ATSSPDLAIFDAVGRVAIVTFSQYLN..QPFVTKK.WDADPVDDIHLV
  426-  538 (131.64/84.28)	GKVVILTfADG.TVQFRD.RFTFEE.LYATPNLTKCSMMQlGDDG....KVRWSklhfpngdigetmqdahyAASIASLAITTAASTWHQCNYDDMLGivQPYAKKKkFTQDWITELTRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.51|      24|      72|     314|     337|       7
---------------------------------------------------------------------------
  314-  337 (38.93/30.55)	DLGDAGPSTS..LAELTHLQVLPSLI
  387-  412 (34.58/26.15)	QLGSRGSSISseKPNATHLRRLEPIV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01269 with Med16 domain of Kingdom Fungi
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