<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01267

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMQGASLTLSFVGITVLDTTGMSAGENDSMAGQHGSQLANGQGSQTQPDEIFHITDGFVPLSLLLTRLAQTTHNALQAKMVELAKMPVPAAAMNGNAAHANSPDDVSSDNLRKKTALLNFAQDMHAKWVKALVIADWSRKAESVSKLIDLKFHIDQQRILFDAALDNIVNIKRDLTYARMPSPDLKTALQVLATGRAPWIPDLQYIPLPQLTADEQVKWMNDLDTLLSIRLNLEDYDKIPQQFKNYHISSGRVTFKVPGEFEVDLTIADEDFEKQFWFIDFRFAFSPAAQSLPESLRVYLEGCVNDALARDGLTGCYQFLHEYVLTMKINELRRQAIQLSKTSWTGTLMVEPLHRALAIQYWTSRSAVTKSKSWILVAINSGRKQNAPADAKAASYLVAKWYRDGKEVKDMEIPLDADNLSAESLLKTVVGRHVESILTSIHDKLLTAPRFQNREAGLKLRISKDDPAASSLKTQVGYRNSAALLIEPSTGAFAIKPHSKFVINYERQLNNGKTPIDDGVMCLEQVRCAMLEDELNRRGSCMGWVIRKAPITNEELHTVTKTRGPMRVLWLQKNGWKSSWFVAIILSLAGDQWWLLETSDTRAVPFYARLPLRKGHPDLTDKFWDNLTLFSTGMLAQSVDMRELHRRSIKSRPNETVVWSLPQQVRLPALEVALSAIYPAMLFDSAEAESDPPSADQTALAATISSILRNTHVNRHPASQPWAFDLVTIKFRGVEVQPVRTESSGQGTLQCLSDAFIKVRKPARYATLSGSIDRDVSYNSRRGEFCLRLRHVAGQSLIDVLETKVKAIDRFVTFLDALDRAKDTIECGKVTLREVTFFYGSDKSSAGHEGEQQPQKWRVVLDLSDKDIDVQFEQGNPHLRVLDLAKSLVNAADGINGLLHWLPTSLPTFRTIDNIQSRWEDLQAQNRGQVDFTVKTMDWMRIHYDIAQGASTGASDRRHLVLEMQCRLRRDEPWWHIRRSAEILVAGVPARSDDFTNALDPIWQGRGDGWHGLASGASGRHGDGVAALLQAVDNAIYTVATASWVGEPDGTGNAPLVVVD
Length1059
PositionTail
OrganismStachybotrys chlorohalonata (strain IBT 40285)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.08
Grand average of hydropathy-0.273
Instability index41.47
Isoelectric point6.62
Molecular weight118244.18
Publications
PubMed=25015739

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01267
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.67|      30|     179|     535|     629|       1
---------------------------------------------------------------------------
  590-  624 (46.85/108.68)	DQWWLLETSDTRAVpfyARLPLRKGhpDLT...DKFWD
  971- 1003 (53.82/ 6.41)	EPWWHIRRSAEILV...AGVPARSD..DFTnalDPIWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.05|      26|     179|     286|     316|       2
---------------------------------------------------------------------------
  286-  316 (42.75/45.97)	PAAQSLPESLrvyleGCVND.ALARDGLTGCY
  466-  492 (41.29/30.41)	PAASSLKTQV.....GYRNSaALLIEPSTGAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.07|      25|      44|     749|     773|       8
---------------------------------------------------------------------------
  749-  773 (43.69/31.62)	QCLSDAF.IKVRKPARYATLSGSIDR
  794-  819 (36.39/25.05)	QSLIDVLeTKVKAIDRFVTFLDALDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.81|      76|     604|      16|     101|       9
---------------------------------------------------------------------------
   16-  101 (106.35/89.68)	LDTTGMSAGENDsMAGQHGSQLangqgsQTQPDE..IFHITDGfVPLSLLLTRLAqTTHNALQAKMVELAKMPvPAAAMNGNAAHANS
  628-  705 (123.46/73.09)	LFSTGMLAQSVD.MRELHRRSI......KSRPNEtvVWSLPQQ.VRLPALEVALS.AIYPAMLFDSAEAESDP.PSADQTALAATISS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01267 with Med14 domain of Kingdom Fungi
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