<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01262

Description Uncharacterized protein
SequenceMGVQPRPPQRTLSNPSLSVQRPSIPQQQQRSLSTQYLPQSPVRKDSVIDLSADSPDAAQNRHGTTPRRGGSRLRLELSSEAFSNILPITTDSPQSMTPSRTAPLSDAMDPGNMSPALSRASQQDLDNPPMPMPKRRPPTAQAVQTPRKSASTTAPAKRDSRPKPYTIETPSAAPRFVSTHKRSNHNTGRDPFSRGLFSGYADFYPWNGNHHEDEWTTEAIQKGTWDRNTQTESASARQAIFPSLKQKSGLNLLSQIYTGILATRKLRGQITAPSTFKPPPRVTLTDTKREVWLRDLSNPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGVNGAFVMGGELKWVRDWTTFVEQFLDGVVWQFTEADWKNKVIYAIRLATHLYSDHLLDRDHYLEWIVAGLESSTQTRLPMWILIAQIYWADILRSRKHARRMVASLLSHLDAVHTDLDGDIFIQLSGRLAVLLTSLIQTTPESFVNPNTWFKYRHTLKANLYHDDAALAAFHAVDLRVSRLTVGNTESSPATPQQLVSLLDSILQKSMEGDLPEKCWATSDDKQEAASTIIRWAASVHRPGLSKVYVAARVIRAWAVYGSDLTHVILGILEDVADNDHARKQLMYRLITELARSGHFSIPYYFQWLIARGGYTNASEIDPDDGPCAMRLLVELPVHCFWDRWKIERANLLRRAGGYSVESEQQDMQNAFRCIQHALGLPIPAGDPISQRKPISVRKLGHMLKSSSRALNSHVAAQLRDAVDHQLSGMAHFAISLPMFTSVRAIMESTEDFAMFADILRSCVKASNPEVLASCADTINLNLRIFLALGAAEELFDSLLQRLRMMGPGQTVPARPLLAALSSLAERMPSRVQMAQELLQELIQNDRSNAIDACSPVSDSMMSHMHNRENEVSEEIEKLLTSGNSIDPPTMNRMFRNIVPRLDVGWAKADDSRRVLALLLARLRIFDTQHFDKLMSDWLCHLRALGTRPELMQLLPLLVSLGCISIDVLMRTANVSPPNSSDASFQNTGRPGSSTYLQELLALLLVELPKSVALTAEETYRFQIQQQSAMSEHSKDLLALIRNALLEYALLRQHQPDTSLILDDPNCQECILEALRYLVVEDAGAVAEAIAVKSLPAEAVRLVQTLVSELLVPGASTGASISFDEVLKLANERTMPFCQLKLNIELSLAQSSTGAAGEHGPSAFDLFAEAMDRAIEARNIMWTTMLPGLNDDIAQSLRSQACNRFLKLMPSIKSSTFEQDATDSARIQMAQNLLGVIESIVLGQAPQKFAQVFTSALVEKLADLWDMVAAKNGEKPAVQVAALGHWLPVLLRFIALHSAQPEGVPGSTQSGPITSKPTSINIPNFDARARSVLVLCGLMLELETLPACSRGTLAQQVFDLALVLIDPLPEEMRLTCAKSILQMPGAPPSLSASSDSRLYYLFSAAQPSSADNLMLAHREKPPTTSGAARALYATGHAPNEKLTPFVLRRWELLHEPTPNVGENDTSLNLRLFEAVKVH
Length1527
PositionKinase
OrganismStachybotrys chlorohalonata (strain IBT 40285)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Stachybotryaceae> Stachybotrys.
Aromaticity0.06
Grand average of hydropathy-0.208
Instability index50.94
Isoelectric point8.01
Molecular weight169252.81
Publications
PubMed=25015739

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01262
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.87|      33|      35|     126|     158|       1
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   91-  123 (52.23/28.07)	DSPQSMTPSRTAPLS.DAMDPGNMSPALSR..ASQQ
  126-  158 (58.35/32.30)	DNPPMPMPKRRPPTA.QAVQTPRKSASTTA..PAKR
  159-  194 (46.29/23.96)	DSRPKPYTIETPSAApRFVSTHKRSNHNTGrdPFSR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.74|      26|      41|     287|     316|       2
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  287-  316 (37.01/40.88)	TKREVWLRDLSnPAISLRRLSRtipHGIRG
  330-  355 (46.73/33.82)	TERAVWLAKCV.GANEIRAFKR...KGVNG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.77|      24|      35|       5|      28|       3
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    5-   28 (44.44/21.35)	PRPPQRTLSNPSLSVQRPSIPQQQ
   38-   61 (41.33/19.39)	PQSPVRKDSVIDLSADSPDAAQNR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.54|      34|      35|     390|     424|       4
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  390-  424 (52.44/35.69)	KNKVIYAIRLATHLYSDHLLDRDHyLEWIVAGLES
  427-  460 (57.10/34.25)	QTRLPMWILIAQIYWADILRSRKH.ARRMVASLLS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.47|      17|      41|     662|     680|       5
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  662-  680 (30.06/24.84)	GGYTNASEidPDDGPCAMR
  706-  722 (32.41/19.76)	GGYSVESE..QQDMQNAFR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.73|      34|      40|     841|     880|       6
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  841-  880 (52.00/36.73)	AEELFDSLLQRLRMMGPGQTVPARpllaalSSLAERMPSR
  884-  917 (59.73/31.07)	AQELLQELIQNDRSNAIDACSPVS......DSMMSHMHNR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.06|      20|      35|    1034|    1053|       7
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 1034- 1053 (34.35/23.75)	FQNTGRPGSSTYLQELLALL
 1071- 1090 (33.72/23.16)	FQIQQQSAMSEHSKDLLALI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.07|      11|      35|    1158|    1168|       8
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 1158- 1168 (19.48/11.39)	ELLVPGASTGA
 1194- 1204 (18.58/10.48)	ELSLAQSSTGA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.64|      18|      39|     639|     661|       9
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  639-  661 (24.18/28.74)	LITELARsgHFsipYYFQWLIAR
  681-  698 (36.46/22.52)	LLVELPV..HC...FWDRWKIER
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.36|      25|     360|     805|     832|      10
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  752-  776 (41.13/15.17)	MLKSSSRALNSHVAAQLRDAVDHQL
  808-  832 (42.23/18.73)	ILRSCVKASNPEVLASCADTINLNL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     315.90|     102|     747|     472|     612|      11
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  500-  612 (155.42/146.90)	NTWFKYRHTLKANLYHDDAALAAfhavDLRVSRLTVGNTES..SPATPQQLVSLLDSILQKSMeGDLPEKCWATSDDKqeaasTIIRWAASVH.RPGLSKvYVAARVIRAWAVYGS
 1252- 1356 (160.48/83.94)	NRFLKLMPSIKSSTFEQDATDSA....RIQMAQNLLGVIESivLGQAPQKFAQVFTSALVEKL.ADLWDMVAAKNGEK.....PAVQVAALGHwLPVLLR.FIALHSAQPEGVPGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.67|      32|     410|    1000|    1031|      16
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 1000- 1031 (55.52/41.58)	LMQLLPLLVSLGCISIDVLMRTANVSPPNSSD
 1413- 1444 (57.15/43.08)	LIDPLPEEMRLTCAKSILQMPGAPPSLSASSD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01262 with Med12 domain of Kingdom Fungi
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