<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01260

Description Uncharacterized protein
SequenceMSNPYSQPPTGLSDQQTARMALQQQARSGPGSDLGRGLGPGRHGGPGEPGTNASPVIDLTGSNDEDDEDLESSRPSKRLRIDTKGHDEIARILNAGVRLVQGASDDVNDGKNAEVTDQNIPFVEIERPPASFQDQLAYISVDGGGQQPQSSSSPLPLPPRPRRSLFMRDKTETAPEDDEQEYMAVQTTPYTMEKPAAAARLADNTILDFHPWTGNHPEDALNEQTAKQGFYDRIQLSQNESNTARPSLYAHFKNPNGLKALSHIFAAALKRRQAMTKVTPNSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKILLDQCLGKNIPIGRAIWLAKCVGANEIRAFKRKGTAATIASGLETKWVKDWTGSVQQFLEGVVQSHEDAGWIENQAYAMRLSGRLFLEQLLDQDAYLEWFLGSLHASNLDMLLVWLSTIGVYWKNLTSYRKRGRRLAQTLLDKLAWALNVNRSAVLNPLITRLQSLIRSFITSYPSSFILPLTWSQHQKALTACFNTTVPLETAILAQLIARNARLSRISPQSAINSPQSIPRPAPQQLISLLDAPCASNGFPLLAAKCLALPLDHRTLIHTLLEWSSTPFRYGCARIYASARLLRRWRKLSIDTDAHILSFLAENSKYSARQLDNAYHLVSELVRSHSFSVGKYLEWLMARGAVRCPEMSGQYLTADVELLRHLPSSRLPEHIWNLRNTLLSRAGVSVDAEARQIRQIKTDLLQRHSDIFVGHVGTIDTEMMDGDIDWASLSWTVKSEISHWIREQVALKLRAQAQVQNQPSGNATAQETASMIKPGQFYFLRYILERMGDFSILADVLKLLSQSSNPTVLASVTDTLNHHLPSFTAIGATMDLLQSFAITYSKLSKTEAHVQDLIVSLLDVAIVIPSEASTVAVLRRDLARYDKKSAMAASSPVSEHMADTLNPVNPTFGGMLDQLLASGNCMDDATLMRIFDLLIQKLETGKADISITSSEAARYLAQLRLFNPKTFDGLMIKRVIGMIHTSPRPKLSHFLPPLIGVGCITLPAFFGLVKRLLLDADKTGENNIPDVLHLRLDMLSVLALGTTDQNTVPDLVSKFTC
Length1096
PositionKinase
OrganismTrichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.07
Grand average of hydropathy-0.238
Instability index45.85
Isoelectric point8.82
Molecular weight121472.41
Publications
PubMed=22951933

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01260
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     301.20|      92|      94|     862|     955|       1
---------------------------------------------------------------------------
  691-  739 (48.22/24.12)	..LTADVE...LLRH..LPSSRLPE...HIWNLRNTLLSRAgVSVDAEARQIRQIKTDL......................................................
  863-  955 (148.11/92.45)	TAIGATMD...LLQSFAITYSKLSKTEAHVQDLIVSLLDVA.IVIPSEASTVAVLRRDLaRYDKKS..........AMAASSPVSE..HMADTLNPVN....PTFGGMLDQLL
  959- 1052 (104.87/64.01)	NC....MDdatLMRIFDLLIQKLETGKA..........DIS.ITSSEAARYLAQLR....LFNPKTfdglmikrviGMIHTSPRPKlsHFLPPLIGVGcitlPAFFGLVKRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.50|      43|     162|     431|     474|       2
---------------------------------------------------------------------------
  328-  379 (36.94/14.88)	....LDQCLgknipigraIWLAkCVGA..NEIRAFKRKGTaaTIASGLETK...WvkDWTG
  389-  427 (53.73/24.27)	VQSHEDA...........GWIE.N.QAY.....AMRLSGR..LFLEQLLDQdayL..EWFL
  431-  474 (66.84/35.92)	HASNLDMLL.........VWLS.TIGVYwKNLTSYRKRGR..RLAQTLLDK...L..AWAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.75|      44|      89|     188|     234|       3
---------------------------------------------------------------------------
  188-  234 (75.80/44.91)	TPYTMEKPAAAARLADNtilDFHPWTGN..HPEDALNE..QTAKQGFYDRI
  279-  326 (70.95/35.99)	TPNSTFKPPPRVTLTDN...KREAWLRDlaNPSVPLRRlsRTIPHGIRGKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.17|      12|     102|      44|      55|       4
---------------------------------------------------------------------------
   44-   55 (24.47/13.15)	GGPGEPGTNASP
  143-  154 (23.71/12.51)	GGGQQPQSSSSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01260 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARILNAGVRLVQGASDDVNDGKNAEVTDQNIPFVEIERPP
2) DNTILDFHPWTGNHPEDALNEQTAKQGFYDRIQLS
3) MSNPYSQPPTGLSDQQTARMALQQQARSGPGSDLGRGLGPGRHGGPGEPGTNASPVIDLTGSNDEDDEDLESSRPSKRLRIDTKGHDE
4) SFQDQLAYISVDGGGQQPQSSSSPLPLPPRPRRSLFMRDKTETAPEDDEQEYMAVQTTPYTMEKPAA
90
203
1
131
129
237
88
197










Molecular Recognition Features






MoRF SequenceStartStop




1) DQLAYIS
2) TARMALQQ
134
17
140
24