<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01213

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVGRAAEESFLSLTELVEKAKSPELSDTEKKLSLLKYVVKTQQRMLRLNALAKWCKQLILFSNKSIDASQTYVFVIATVPLINRLQDVGSTLSAHDICFTQAADSLFFMHEGLQQARAPVYDVPSAIEVLLTGSYQRLPKCVDDVGMQCSLDEHQQKPALRKLEVLVRSKLLEITLPKEITEVKVSKGTVTLSVEGEFKVLVTLGYRGHLSMWRILHLDLLVGERSGGPIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQVRTLLHGRWKDAIRFDLISDTGTAPANQEGEADSVSLKTPGVKLMYWLDSDKNNAGSFVKIEPGSDLQIKCSHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLKAICCNRYTRLLEIQKELLRSDRICRAPSDVILQAFLDEPGSEGSSMVDSKEQKEPEVLRVRAYGSSFFTLGINIRTGKFLLQSSKSVLTPSILVEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLGLEVYEHGFGVNKAPKSLSDGSSILALGFPDCESSHLLLMELEKDFTPLFKLAETQTDGSGKPQFLNDLSNVLRVKKIDIGQIRILEDDLNLITSDVASFVSSFSDAERSLSQASGHRGPGLVEESLAEMSGGQLSFSSIVDEVFGHQKVTSSADGKAPLLTSYQSDSFYSMQGPLESSSFNLLSSPPPGKGSAMKKNSNQELSMVLSPSRTVVSESADLAVTSDGPLLRKDQKSRKRSASDLLRLIPSLQGVEGVTHPNKRSKTSASQALSTAVVTSAKTVGCSYGDLIAEANKGNAPSSVFVYALLHVVRHSSLSIKHAKLTSQMEALDIQYVEEMGLRDSFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFRDLWELQKGSKSTPWGSGVHIANSSDVDSHIRYDPEGVVLTYQSVEADSIKKLVADIQRLSNARRFSLGMWKLLGIKADEKTEEPGGANPAVKGPTGGKGGGEAVDRWRAFKIEAVGLTSLWFSFGSGIMARFVVEWESGKDECTMHVSPDQHWPHTKFLEDFINGGEVESLLDCIRLTAGPLTALAAATRPARASSATGVTVVPATATSRQSNQTQQTQPSTLAAPNAVGQSASGSALASPSPAPSPLGGSFHGAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTGSQGGATNPNSGSRVNFSPSSVMSRAVMSRVGSVASGSLVAGSGLSVRRPLGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKENEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQQQQQNGSSGTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPIPVLREFLKLIAWKKGLSQSQQAGEVAPAQRPRIELCLENHSGADVETSCAAKSNIHFDRPQSTVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYTFGDNPSVTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSAAGDLTQGKLKLVADSVQRTLHLCLQGLSSNNTLQKEFTI
Length1655
PositionTail
OrganismBrassica napus (Rape)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Brassiceae> Brassica.
Aromaticity0.07
Grand average of hydropathy-0.116
Instability index45.22
Isoelectric point6.71
Molecular weight179958.12
Publications
PubMed=25146293

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01213
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     446.08|     100|     265|    1231|    1333|       1
---------------------------------------------------------------------------
  896- 1007 (79.21/42.46)	CW...................................dvkindQHFRD.LWE..LQKGSKSTPWGSGVH.IANSSDVDSHIRYD.PEGVV......................................ltyqsveadsikklvadiqrlsnarrfslgmwkllgikadekteepGGANPAV.....KGPTGG...KGG
 1114- 1187 (84.16/44.88)	.......................................................................ATSRQSNQTQQTQ.PSTL...AAPNAVGQSASGSALA.SPSPAPSPLG.GSF.HGAA..............................................GRSGPGIVPsslLPIDVSvvlRGP
 1188- 1331 (142.19/93.03)	YWiriiyrkrfavdmrcfagdqvwlqpatppkggasiggslpcPQFRPFIMEhvAQELNGLEPNLTGSQgGATNPNSGSRVNFS.PSSVMSRAVMSRVGSVASGSLVAGSGLSVRRPLGSGVP.AHVR..............................................GELNTAIIG...LGDDGG...YGG
 1498- 1589 (140.51/82.01)	...........................................PAQRPRI......ELC.LE.NHSGAD.VETSCAAKSNIHFDrPQSTVDFA.LTVVLDPAHIPHINAAGGAAWLPYCVSVRlRYTF..............................................GD.NPSVTF...LGMEGS...HGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     327.38|     113|     263|     141|     270|       2
---------------------------------------------------------------------------
  141-  270 (157.42/140.14)	EVLLTGSYQRLPkcvDDVGMQCSLDEhqqkPAlRKLEVLVRSKllEITLPkEITEVKV.SKGTVTLSVE...GEF......KVL...VTLGYRGHLSMWRILHLDLLVGERSGGPIKLEVTRRHILGddLErrmsVAENPFTI
  409-  534 (169.97/104.38)	ELLRSDRICRAP...SDVILQAFLDE....PG.SEGSSMVDSK..EQKEP.EVLRVRAyGSSFFTLGINirtGKFllqsskSVLtpsILVEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLG..LE....VYEHGFGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.40|      14|      16|     342|     356|       3
---------------------------------------------------------------------------
  342-  356 (21.15/17.04)	KNNAGSFVkIEP..GSD
  360-  375 (22.24/12.55)	KCSHSTFV.IDPltGKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.84|      15|     323|    1057|    1075|       7
---------------------------------------------------------------------------
 1057- 1075 (23.13/27.69)	DQHWPHTKFledFInGGEV
 1382- 1396 (29.71/18.65)	DQEQPALRF...FV.GGYV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01213 with Med14 domain of Kingdom Viridiplantae
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