<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01190

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVGRAAEESFLSLTELVEKAKSPELSDTDKKLSLLKYVVKTQQRMLRLNALAKWCKQLILFSNKSIDASQTYVFLIATVPLINRLQDVGSTLSSHDICFTQAADSLFFMHEGLQQARAPVYDVPSAIEVLLTGSYQRLPKCVDDVGMQCSLDEQQQKPALRKLEVLVRSKLLEITLPKEITEVKVSKGTVTLSVEGEFKVLVTLGYRGHLSMWRILHLDLLVGERSGGPIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQVRTLLHGRWKDAIRFDLISDTGTAPANQEGEADSVSLKTPGVKLIYWLDSDKNNAGSFVKIEPVSDLQIKCSHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLKAICCNRYTRLLEIQKELLRSDRICRAPSDVILQAFLDEPGSEGGSMVDSKEQIEPEVLRVRAYGSSFFTLGINIRTGKFLLQSSKSVLTPSILVEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLGLEVYEHGFGVNKAPKSLSDGPSILALGFPDCESSHLLLMELEKDFTPLFKLAETQTDGSGKPQFLNDLSNVLRVKKIDIGQIRILEDDLNLITSDVARFVSSFSDAERSLSQASGHRGPGLVEESLAEMSGGQLSFSSIVDEVFGHQKVTSSADGKALLLTSYQSDSFYSTQGPLESSSFNLLSSPPPGKGSAMKKNSNKELSMVLSPSLTVVSESADLAVTSDGPLLRKDQKSRKRSASDLLRLIPSLQVVEGVTHPNKRSKTSASQALSTAVVTSTKAIGCSYGDLIAEANKGNAPSSVFVYALLHVVRHSSLSIKHAKLTSQMEALDIQYVEEMGLRDSFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFRDLWELQKGSKSTPWGSGVHIANSSDVDSHIRYDPEGVVLTYQSVEADSIKKLVADIQRLSNARRFSLGMRKLLGIKADEKTEEPGGANHAVKGPAGGKGGGEAVDRWRAFKIEAVGLTSLWFSFGSGILARFVVEWESGKDECTMHVSPDQHWPHTKFLEDFINGGEVESLLDCIRLTAGPLTALAAATRPARASSATGVTVVPATATSRQSNQTQQTQPSTLAAPNAVGQSASGSALASPSPAPSPLGGSFHGAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTGSQGATNPSGSRVNFSPSSAMSRAVMSRVGSVASGSLVAGSGAMSRAVMSRVGSVASGSLVVGSGLSVRRPPGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKENEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQQQQQNGSSGTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPIPVLREFLKLIAWKKGLSQSQQAVEVAPAQRPRIELCLENHSGADVETSCAAKSNIHFDRPQSTVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYTFGDNPSVTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSAAGDLTQGKLKLVADSVQRTLHLCLQGLREGSSNNNTLQKEFTI
Length1680
PositionTail
OrganismBrassica napus (Rape)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Brassiceae> Brassica.
Aromaticity0.07
Grand average of hydropathy-0.096
Instability index45.99
Isoelectric point6.97
Molecular weight182415.03
Publications
PubMed=25146293

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01190
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.48|      22|      22|    1274|    1295|       1
---------------------------------------------------------------------------
 1152- 1173 (27.96/11.02)	PSPLGGSFHGAAGrSGPGIVPS.
 1274- 1295 (42.49/20.50)	MSRAVMSRVGSVA.SGSLVAGSG
 1297- 1318 (43.02/20.85)	MSRAVMSRVGSVA.SGSLVVGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     344.33|     116|     265|     141|     267|       2
---------------------------------------------------------------------------
  141-  267 (175.90/146.33)	EVLLTGSYQRLPkcvDDVGMQCSLDEQQQKPAlrkleVLVRSKllEITLPkEITEVKV.SKGTVTLSVE...GEF......KVL...VTLGYRGHLSMWRILHLDLLVGERSGGPIKLEVTRRHILGDDL.ERRMSVAENP
  409-  538 (168.43/112.59)	ELLRSDRICRAP...SDVILQAFLDEPGSEGG.....SMVDSK..EQIEP.EVLRVRAyGSSFFTLGINirtGKFllqsskSVLtpsILVEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLGLEVyEHGFGVNKAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.29|      40|     265|    1228|    1269|       4
---------------------------------------------------------------------------
 1228- 1269 (66.23/57.46)	LPCPQFRPFiMEHVAQElNGLEPNLTGSQGA...........TNPSGSRVNFS
 1490- 1540 (60.06/42.08)	LPIPVLREF.LKLIAWK.KGLSQSQQAVEVApaqrprielclENHSGADVETS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.79|      18|     265|    1335|    1352|       5
---------------------------------------------------------------------------
  992- 1007 (31.08/16.39)	GGANHAV..KGPAGGKGG
 1335- 1352 (33.66/18.40)	GELNTAIIGLGDDGGYGG
 1594- 1610 (33.05/17.93)	GD.NPSVTFLGMEGSHGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.84|      15|     338|    1057|    1075|      13
---------------------------------------------------------------------------
 1057- 1075 (23.13/25.62)	DQHWPHTKFledFInGGEV
 1403- 1417 (29.71/17.25)	DQEQPALRF...FV.GGYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.11|      39|     434|     742|     782|      19
---------------------------------------------------------------------------
  742-  782 (57.34/44.62)	DLAVTSDGPLLRKdQKSRKRSASDlLRLIPSLQV.VEGVTHP
 1179- 1218 (68.77/43.94)	DVSVVLRGPYWIR.IIYRKRFAVD.MRCFAGDQVwLQPATPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.35|      15|      23|    1354|    1369|      20
---------------------------------------------------------------------------
 1354- 1369 (22.53/17.09)	W....VPLVaLKKVLRGILK
 1375- 1393 (21.82/11.40)	WlfaqLPDL.LREILGSILK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01190 with Med14 domain of Kingdom Viridiplantae
Unable to open file!