<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01155

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLRNVSWFQFLPSEAELSPASDTTSSRAEQNDVATYLVLSSHLRLQKEGFLSTWTNSFVGPWDPSQGLYNPDEKIKLWLFLPGRHSSITDKAQAVVSKLRVVASGIWVAPGDSEEISVAFSQSLRNCIERALTGLSYMRFGDVFSKFSPQSEDYLRRGQPTVEFIFAATEEAVFVHVIVSAKNVRALSSGDAERLLRSSLKNSSYRLPVIVSPHGMRGSLTGFCPNDLVKQVYFSSGNIGTSSGYIGLPSHVDRGSRLINDNHCYVEVTLGCCQSINDNTSQTNSTFAVNLPHNQRPEPSVGSRDHRKGQQDISSVREKKFIYPAEAVLVPILQSAFAKFSLKRFWLQNWIGPSLAGSSLYIHWAGDFDFLRSSGNKSDGFYEKNGYNSSGSSRNSSISSTSSASSGSGWRMASRTGDLDADADSLTCRQSGVTCNDDRPKSGSKRSRTGRTESFGQVGITDDQIGWDWDDDDDDDDDDDRGVGMDIKALLSEFGDFGDFFENDALPFGEPPGTAESHTLMIPLDSAEIGCSPVDMMDVSDQIVLPDGFSSFESFNPVPPIIDECLIKSQEVINSSVTSAPLNQMSSSSTGEFDHLIKAEAMMTFAPEYGAVEVPMSEISSFKSPYLPKSHKVESSHSRTSNYVYGPTPPATDSDGAADKNSLGSKACIGNNDGRTLFQSRDYYTQVEGRKDQHKMLPTVISDNSSTKEGVSQLKYSNFSAVKTVQGKKSDGISAVVSTLLSSKTLLATDVGSVMFQAFMSRMRHIIISSKHSSPVNLTRLSGKLFLNQLSNEPSSLTDNISARNEIYKKEIPTRIAGDFDGGMIDSHMSAPVGVWRTVSVPKTAKPASSPNIEAGSSLPHSSFSEDSLLSYGQRQPLQELLDGIALIVQQATSFVDLALDSDCGDGPYGWLALEELWRRELSCGPSAGHAGCGGTLASCHSLDIAGVKLVDPLSAEVFPSSVITLLQSDIKTALKSAFGQSDGPLSVTDWCKGRNHSMDGGSTAESSLREAMSIDSGKREETAQSQDIYSSELLRPTLFVLPSPSILVGYQDDWLKISTNALPHWEKAPFEPYALPKNMSYTVVCPDIDPLTSAATDFFQQLGTVYEACRLGTHLPHILGNQMETDAGRLSLSGFVLLDCPQSMKIESNNTSLLGSLSDYFLSLSNGWNVTSYLKSLSRALKGLKLESCLYTNQKEGSATSPCIVVYIVCPFPDPSAVLRTIVQSSIALGSGIRPDKDRRSLLNSQVARAFGSSAAVDEASISHIPVLSGFSVPKLVLQVVSVDSIFRITSPSFNELVILKDTAFSVYNKARKISREMPNDAFQSSSLSSRSSSALTPMSSISGIWKDCVGSRMTGSTHPRDGERDGSMRTSWDSWQMTRSGGLSCDPNRNEDFYLNDESFYLFEPLFILSEPGSVERELSPTFGGLGSESSKPITEDGGRGSGLGVNAMEGIPSGSSSQGDTSQVEGKNIPSLHCCYGWTEDWRWLVSIWTDARGELLDTHIFPFGGISSRQDTKGLQCLFVQVLQQGCQILQACSSPDNGSSKPRDFVITRIGNFFELEYLEWQKAIYSAGGPDIKKWPIQLRRSAPSGIATNCSVSSLQPPDMSLIQERASSSSTFYSSHSKPSNFVKGSIGQSAGRKHIMGGQTISGTPRGLFQWVHSISFTSISLDQSLHLVLPVELVSPGGTGMSSSNYIEGFTPVKSLGSTAYSYMMIPSPNMRFLHPSPLQLPTCLTAESPPLAHLLYSKGCAIPLSTGFVVSKAVPSMRKDSRINMKEEWPSVLSVSLIDYYGGYDNAHDKILQGIMKQGGGGTQETRDFEVESHLILESIAAELHALSWMTASPAYLDRRTALPFHCDMVLRLRRLLHFADKELQTSR
Length1888
PositionKinase
OrganismBrassica napus (Rape)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Brassiceae> Brassica.
Aromaticity0.08
Grand average of hydropathy-0.275
Instability index53.03
Isoelectric point5.56
Molecular weight205550.33
Publications
PubMed=25146293

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01155
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     216.75|      72|     488|     495|     575|       1
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  495-  575 (118.22/87.82)	DIK.ALLSEFG......DFGDFFE..NDALPFGeppGTAESH.TLMIPLDSAEiGCSPVDMMDV.SDQIVLPDGFssfesFNPVPPII....DECL
  979- 1065 (98.53/54.37)	DIKtALKSAFGqsdgplSVTDWCKgrNHSMDGG...STAESSlREAMSIDSGK.REETAQSQDIySSELLRPTLF.....VLPSPSILvgyqDDWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.45|      37|     270|     793|     829|       2
---------------------------------------------------------------------------
  634-  662 (21.92/ 9.30)	................PY.LPKSHkvesShsrTSNYVYG....P.TPPATD.
  793-  829 (63.90/44.27)	KLFLNQLSN......EPSSLTDNI....S...ARNEIYKKEI.P.TRIAGDF
 1066- 1108 (51.63/34.06)	KISTNALPHwekapfEPYALPKNM....S.....YTVVCPDIdPlTSAATDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.73|      32|     270|      20|      60|       3
---------------------------------------------------------------------------
   20-   60 (41.48/39.64)	LPSEAELSPASDTTSSRAEQNDVatylvlsSHLRLQKegFL
  300-  331 (57.25/31.63)	LPHNQRPEPSVGSRDHRKGQQDI.......SSVREKK..FI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.08|      30|     270|    1147|    1207|       4
---------------------------------------------------------------------------
 1149- 1182 (49.21/66.32)	DCPQSMKIESNNTSLLGSLSdyflSLSNGWN..VTS
 1331- 1362 (47.88/11.10)	DAFQSSSLSSRSSSALTPMS....SISGIWKdcVGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.00|      12|     270|     387|     398|       6
---------------------------------------------------------------------------
  387-  398 (23.20/12.16)	SDGFYEKNGYNS
  663-  674 (19.80/ 9.29)	SDGAADKNSLGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.49|      10|      15|    1436|    1445|       9
---------------------------------------------------------------------------
 1436- 1445 (17.64/ 8.48)	GLGSESSKPI
 1454- 1463 (17.86/ 8.67)	GLGVNAMEGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.77|      28|     292|    1262|    1316|      11
---------------------------------------------------------------------------
  229-  257 (46.79/15.72)	LTGFCPNDLVKQVyFSSGNI..GTSSGYIGL
 1278- 1307 (42.98/33.39)	LSGFSVPKLVLQV.VSVDSIfrITSPSFNEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01155 with Med13 domain of Kingdom Viridiplantae
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