Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSVETLRTLEQVRQRLNTLANSIGKLLHDLDSNDPLPSWPSLQNSATLLSHNLASLHHTLVNAQPLLAGAHVYPLPSYPGRTQEDLLTQLLRKKLQPQVEDWIANGVRHAANTNQDPAQTNGTSSNGLEPGPPPQQTMTTAQLADLWNWAGPEGNRVARDMGSDAFDDVFTLEEHELGIENVVTGLRRKLWDSDDEDEDEEGDGEGKNTDGKQNDMDIDMVDTVPDHVRRLQRHNVDPSKPPMTIEHILRFALTAREPPNVVQ |
Length | 263 |
Position | Head |
Organism | Aureobasidium subglaciale (strain EXF-2481) (Aureobasidium pullulans var. subglaciale) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.734 |
Instability index | 46.36 |
Isoelectric point | 4.76 |
Molecular weight | 29266.03 |
Publications | PubMed=24984952 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP01090 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 64.13| 18| 36| 35| 53| 1 --------------------------------------------------------------------------- 35- 53 (30.49/20.08) PLPSWPSlQNSATLLSHNL 74- 91 (33.64/18.08) PLPSYPG.RTQEDLLTQLL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) HVRRLQRHN 2) LRRKLW 3) MTIEHILRFALTARE | 227 186 243 | 235 191 257 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab