<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01087

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGRIVMDSHAAPHTNGLKTDLPTMADTAPAQHNALSIGYSNGTIKEEDELLPPELEHWAHTYVPMGKLLERMAQQCYFELGDLVEQMADLNIAAPQTNGASTSAPDVSKVSVDKKLRLMNFANTQQARFIKALVLSDWARNMGDMDKLIELRMWLTQQDEATSLVANSIVNMKTNMVAAKMPNPNIEGALELLSTSKAPWLPDLGYIAPKPLSAQKLLKTLRDMNFVLSVRLNLHEQLPSHFCNYSIANGRATFVVPDEFELDLAVTDEDTTSPFYFIDIRFLFSDAPPLPDGYARQSLEGKVNQILQLEGLSAAYEFLHGFVLTHKISLLRRQAFELSRTRWTECLHVEPIHRSLVVQYWTGQPGGKSWIEVGIVKGSNGQSSERAHTPARLNIRWFRAGKEVPDVRFDIDAANPSMEQILNQVTAAHMTLRLGTVRDQIVAISPPNSALAIDLNVSSTDPNACALSTKLGQHGSETILRIIPVNGNISISPVSSASIDVERRLNADPSIDAAQIVTYLNCKLVQDQITRQAVQAGWLLMPTDKQADTNKVFQEQIVRRTTFTRHGWGEDWAICLTISLQGVKWWIVHLTYTSPTSRIITTAETLAIPSTTKLFDRQTVMLIESRAVAQVSLSNISSQLRAQNISHEIRHVAASASAQANTSSSPLSSSTTTAVIGMKFEDVMQPSSPVERKTWIPWCGSTMVLTHHGVDETAKDTVKVIHVLKTTLTPQTAETLSPLINKPVQDISFSPNGILALALPTHFGVDLLQLIKTKLSAVERLASCLSALKSRNFAVEKATMQGLVFVYSSPSAPFTLKAGIAFTNQGIHLRFPAAHDNETPHRRILPLLQKLLETPVSCTSPLQESARFENLLNLLHATTPLFSAFTRIENKDSSGKQCKAFSRSLVQHRLVYSEPLHPMVLEIEFRRKEGKDFWSVTLVKNTPDSAEKKEKSLDLLAKAWQGKDLPGVKGFRSGIIADVDAIGKILIAIDEVVRGEEPRVGNGNGNGDGQDIVVLD
Length1017
PositionTail
OrganismAureobasidium subglaciale (strain EXF-2481) (Aureobasidium pullulans var. subglaciale)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.06
Grand average of hydropathy-0.153
Instability index42.13
Isoelectric point6.65
Molecular weight112226.15
Publications
PubMed=24984952

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01087
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.16|      14|      70|     748|     761|       1
---------------------------------------------------------------------------
  748-  761 (24.07/13.25)	ISF...SPNGILALALP
  804-  820 (16.81/ 6.98)	LVFvysSPSAPFTLKAG
  821-  833 (23.27/12.56)	IAF...TNQGI.HLRFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.30|      26|     108|      95|     122|       2
---------------------------------------------------------------------------
   96-  121 (46.19/26.36)	PQTNG....ASTS....AP........DVSKVSVDKKLRLMN
  185-  226 (28.10/10.62)	PNIEGalelLSTSkapwLPdlgyiapkPLSAQKLLKTLRDMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.72|      74|     108|     310|     395|       3
---------------------------------------------------------------------------
  310-  395 (112.40/99.83)	LEGLSAAYeflhgfvLTHKISLLRRQAFELSRTRWTEC..LHV...EPIHRSLVVQywTGQPGGKSWIEVGIVkgsNGQ......SSERAHTPARLN
  423-  507 (107.32/66.80)	LNQVTAAH.......MTLRLGTVRDQIVAISPPNSALAidLNVsstDPNACALSTK..LGQHGSETILRIIPV...NGNisispvSSASIDVERRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.36|      22|     107|     585|     614|       5
---------------------------------------------------------------------------
  592-  613 (38.46/38.01)	TYTSPTSRIITTA......ETLAIPSTT
  663-  690 (32.91/ 9.78)	TSSSPLSSSTTTAvigmkfEDVMQPSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.44|      18|      78|      56|      73|       7
---------------------------------------------------------------------------
   56-   73 (36.47/24.43)	LEHWAHTYVPMGKLLE.RM
  136-  154 (30.97/19.66)	LSDWARNMGDMDKLIElRM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01087 with Med14 domain of Kingdom Fungi
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