<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01080

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDNLDDLFGDGDADGINAAIAASLDTDALFQRIERSHVVGCCQRLAWSRTSCVAQISADSRKIFVRALCRDKDTAKWSLSGETEVNASEDAIFTHVEWSSSGLDLVAADQFGRLTLFSLTHALNSLERRPVNLSSTVDDLNQIVGLHWFPLNLAGQNRTALIHPAHKEGDRWINNMRLHEVHGVSNPIDNKAAFICVTRRSLVKLIYEQPGQPWTQFNLSLDSLTDSGDVLTHASFCQANQHLVMATYDSSKRLRLYKIMIHWNSNTGDGNNQKPTLNPQMAVLHVELLDQCVPQSSERAASAQLSSLHIEPISQAIENSTFTVVAVFTSVAQDHGGKFSIISRWELQQADTTLHDSFKGLKPTAAQPAAQKPVQRLHRLEDVFSQKAILALQSNVYHNTFAFAASDGTVEFRSRETMQIILADGDTNKATSLPQNGFSFMASDCIDISLSPSMAASIITKPDGTIQLHNAEYLHGWKDAKEDDDLAQAAVVSLARELGIVTCYQIGFDDLLSMIPTDLDRSLRRRFISEIFRTINRNLDFSLDDQKVQSGKVLKDSLLYRIASAQLIISYQTDPKRRDIPAKVAWMLLNLRSVCTNIAQTLTMTQQIRGMYNMEPSLFVSLKGLARWSLDLMILILDDMIEIMRFCNGNFDRERILSYVHEKNTAAVHLLLNSTSRALLAMLGNLVRNFALRIPKTQEKVRLSSRANDIRDSAELQQMETMMGSDLPFDIRLFEHLIMEIDGAVRATYQTAQSSAPLRSHLEQSMLVEADIPEVLSPVLQRLFGDIMPRIESQVDGVAIYTADTAWLGLGEDEEANKRAGMQQYDVLRKCAIAPGAKIRQCRRCGSVIENLVDGHSAAWVQNAHKMCVCLSHWVVA
Length877
PositionTail
OrganismAureobasidium pullulans EXF-150
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.07
Grand average of hydropathy-0.160
Instability index42.72
Isoelectric point5.92
Molecular weight97850.34
Publications
PubMed=24984952

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01080
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.24|      44|      55|     407|     450|       3
---------------------------------------------------------------------------
  407-  444 (57.34/44.54)	..................DGTVEFRSRETMQIILADGDTNKATSLPQNGFSFMASD
  445-  497 (59.92/46.94)	CIDISLspsmaasiitkpDGTIQLHNAEYLH...GWKDAKEDDDLAQAAVVSLARE
  503-  520 (21.99/11.67)	CYQIGF............D........DLLSMIPTDLD..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.10|      41|     261|     299|     361|       5
---------------------------------------------------------------------------
   78-  122 (65.10/38.09)	SLSGETEVNASEDAIFTHVEWSSSgldlVAADQFGRLTLFS...LTHA
  307-  350 (64.99/70.71)	SLHIEPISQAIENSTFTVVAVFTS....VAQDHGGKFSIISrweLQQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01080 with Med16 domain of Kingdom Fungi
Unable to open file!