<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01077

Description Uncharacterized protein
SequenceMISQPAAGTQVPGPRPLNRPALPSKLSNVNLNTQHDISDVDEANHSAYTANGMLQYGGHSANTPDEPKQHIPPRLLSQPTTSLPLPRRPQSLTLTAPGQSRPQLPKPSPTPVLDPSTRANGLQPPAVATKLPKEKAADFFPWTNIEGKHPEDVLNEHLIKSGYSDKPAGASQTESNIARPHLWPSLKNKNGLGVLSALFVQVLDKRASMRLCTAPSTFKPPPRVTLTDTKREAWLKDLANPDVPLRRLSRTIPHGIRGKVLLDHCITKDIPIARAVWLSKCVGANEIRAFKRKGVSGPAALAGELKWIKEWTVFVEQFVDSIISSCGQPGWSQKMNYAVRLGTHFYAEHLLDEEHYMDWILTSLKQSSSERLPVWILLTQIYWKHLISHRKRGHRLAEALLSHAKSLSSTPYGINLQLVTRLNQLISVLAVNHRGCLVLPKSWNDYKTYFASVKPSGRINMEADGLANVTRRNNRLSGATPQATSRTPRLRLLDILDSVDLDVQIDRIATQCESLGLDTRFVLVTVLEWATSKHRSGIARVYLAAQLIRFWSFAGFSADDAVLTMLEKARHDNTVEPRLIYKLVSALARSGHFSVGRYLQWLISMGVLSGSSAAANEAQLLLELPTAYLSSHIVNLRRTLLNRVGYHADAESREIENYKTVLSQHLGGMSLPSPGVPSHEPALTSKPVGAVKMAVAQWLCERVISPSFDSISDTSFNGNLAAFCLVRHTLEQFEDFPSLAKVIAAASNGSNPQILAATADTVNLNIEIFATMGFLPALVSQIYQQQRRLRSRQPLDRTFLLSLSGLVRRVPAGAMYGKTIDSELAMCEIQSSTVACSPASDSMAISHSGSLESDNDIDRVLTSGNTMDEQLMMRMFTTVADRSVKMGSQGLSRASTWFAQLRSFDQTTFEQLVQRLVVRMAETVAPYEAVESVVTSLVGSGCLKLDSFFQIWDKKLNTVKSTEPANASRLAMTCARILIPSTSVMQNQAAEAYRFKVAQNMFCLRNMGVVMRIIWLLLQLSPQSILSKTGNPLEEKVTALLRRYIVKDPKLVAQELVCRSNPMLAQNSVQPLLDSLLGLEPQEQHAKMSVIDKVTKIVGSTTELSLPFSQLALQQISSILSGGNSLSEQDKASLVRTFQTAIENTSSVWPQLLSALDKDLISHIHSWAGECVLEKLSSIVAVDGSMEEEAAVRRYLKAVEASSLAASTQSAPTNVVVMLTEQLKRLGQLAEGINPLDPAQSDKKARVSFGIGVLLQLTTMQHHTIQDANALAQDLIPLMGVLCALLIHPKLQGQQPTLEYILDVASMISDDLSNEHMHTVLRNLPPQARCIPRLRYLFGTHPSPDAWLSLASKVVPSAAQQNPTSTPLQTSSSPASANQSPSMLQRPWPVPARPGMPARPPSVPNTPTLSQAHLQQQQAQQTRMSMGMGVNRGPVELKQTPYMLRRWELMPDPTPIMGANDTSLSLGLFQARKCV
Length1475
PositionKinase
OrganismAureobasidium pullulans EXF-150
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.06
Grand average of hydropathy-0.162
Instability index49.55
Isoelectric point9.26
Molecular weight162152.66
Publications
PubMed=24984952

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01077
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.74|      26|      93|    1019|    1044|       1
---------------------------------------------------------------------------
 1019- 1044 (45.90/35.80)	QLSPQ.....SILSKTGNPLEEKVTA.LLRRY
 1078- 1098 (27.02/17.23)	GLEPQ.....EQHAKMS..VIDKVTK.IV...
 1110- 1138 (26.83/17.04)	QLA..lqqisSILS.GGNSLSEQDKAsLVRTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.65|      20|      93|       6|      28|       2
---------------------------------------------------------------------------
    9-   28 (38.45/22.81)	TQVPGPRP...LNRPALPSKLSN
  143-  165 (25.20/ 6.01)	TNIEGKHPedvLNEHLIKSGYSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.00|      51|      93|     826|     880|       3
---------------------------------------------------------------------------
  826-  880 (85.43/68.34)	MCEiqssTVACSPASDSMAIS..HSGSLESDN..DI.DRVLTSGNTMDEQLMMRMFTTVA
  920-  975 (72.58/48.62)	MAE....TVAPYEAVESVVTSlvGSGCLKLDSffQIwDKKLNTVKSTEPANASRLAMTCA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.69|      51|      58|    1342|    1394|       6
---------------------------------------------------------------------------
 1342- 1394 (86.16/58.88)	PS.PDA.WLSLAsKVVPSAAQQNPTSTPLQTSSSPASANQSPSMLQRpWPVPARP
 1401- 1453 (86.52/50.04)	PSvPNTpTLSQA.HLQQQQAQQTRMSMGMGVNRGPVELKQTPYMLRR.WELMPDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.07|      13|      15|     252|     266|       7
---------------------------------------------------------------------------
  252-  266 (20.08/19.00)	IPhgIRGKVLLDHCI
  270-  282 (24.99/14.89)	IP..IARAVWLSKCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.35|      37|     260|     206|     248|      11
---------------------------------------------------------------------------
  206-  248 (60.12/49.72)	RASMRLCTA.PSTFKPPPRVTLTDtkreawLKDLANPDVPLRRL
  471-  508 (58.23/34.73)	RRNNRLSGAtPQATSRTPRLRLLD......ILDSVDLDVQIDRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01077 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAQQNPTSTPLQTSSSPASANQSPSMLQRPWPVPARPGMPARPPSVPNTPTLSQAHLQQQQAQQTRMSMGMGVNRGPVEL
2) MISQPAAGTQVPGPRPLNRPALPSKLSNVNLNTQHDISDVDEANHSAYTANGMLQYGGHSANTPDEPKQHIPPRLLSQPTTSLPLPRRPQSLTLTAPGQSRPQLPKPSPTPVLDPSTRANGLQPPAVATK
3) VLNEHLIKSGYSDKPAGASQTESNIARPHL
1358
1
153
1437
130
182










Molecular Recognition Features






MoRF SequenceStartStop




1) RLRYLF
2) YMLRRW
1333
1442
1338
1447