<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01071

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADITLPSSLLQPRDENEADTLLSVLGRIHDERGHFRHITEQGLQAEIAANENEEESSDTDEDEDSAEVDGAEGKDRREQLWTARAEMRQHVDSARNEALIALDFVSLLLSKDAPKQAELTMSPHLKQFIKPGTLAMDVWHNVQPDKEQQKLDDTIARSWRMQSLQASADSLLGAATRLEKNVRRETHYWEQVLSVSDKGWSISRLPRERHNLGVRFGFLEALGEFRDRGLAALRSDEDGNVLLDKGMGNNSKVLRVRIQKGDTIIGVSQMPDTSADSESALEARIRHARDSLYEEELFHEIIRESRSLASYGVDMRESIIRLPTRLSPTASLSASETHEVLIDLLPLTDIETKPREKQSEDAWAQAIALALRLFLSYTHRERLVRRSELPQPMSSAKRDTPVASIMRPVLTLLQHRTVLADISTYLQRIHKTLDAASVEASIETAPFDPALLRSAETIDALMQRGLTPIHSRLKVSLKVPHLSEALEFGIEVRTSISPPAFGSAMLVTSPIGLSRVEIPDIQELQDYLNTAIANALGQGILNKLTGWTLNDRCGVLGKANSNDKIGIEVHAGEDSAHDGLILRTPKDRFEWKAQDEMKQNGFWETVKQEVWNGA
Length615
PositionHead
OrganismAureobasidium pullulans EXF-150
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.05
Grand average of hydropathy-0.465
Instability index48.65
Isoelectric point5.30
Molecular weight68836.72
Publications
PubMed=24984952

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01071
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.04|      38|     509|      50|      90|       3
---------------------------------------------------------------------------
   50-   90 (59.66/46.29)	ANENEEESSDTDEDEDSAEvDG...AEGKDRREqlWTARAEMRQ
  560-  600 (66.38/40.97)	ANSNDKIGIEVHAGEDSAH.DGlilRTPKDRFE..WKAQDEMKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.40|      32|     146|     148|     179|       4
---------------------------------------------------------------------------
  148-  179 (51.58/31.97)	EQQKLDDTIARSWRMQSLQASA.DSLLGAATRL
  260-  288 (41.15/24.10)	..QK.GDTIIGVSQMPDTSADS.ESALEARIRH
  295-  327 (43.67/25.99)	EEELFHEIIRESRSLASYGVDMrESIIRLPTRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.18|      26|     216|     232|     257|       5
---------------------------------------------------------------------------
  232-  257 (43.11/30.14)	AALRSDEDGNVLLDKGMGNNSKVLRV
  451-  476 (43.08/30.11)	ALLRSAETIDALMQRGLTPIHSRLKV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01071 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRHITEQGLQAEIAANENEEESSDTDEDEDSAEVDGAEGKDRREQLWTARAEMR
36
89










Molecular Recognition Features






MoRF SequenceStartStop




NANANA