<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01070

Description Uncharacterized protein
SequenceMISQPSAGTQVPGPHPRPLNRPALPSKLSNVNLSRQDDIADVDEANRSAYTANGMLQYAAQPVNTPDEPTQHIPPRLLSHRTTQLPLPRRPQSLTAQGQSRTIIPKPTPAPVLDPSTRANGLHPPAVATKLPRDKAADFFPWTNIEGKHPEDVLNEHLIKSGFSDKPAGASQQESNMARPHLWPSLKNKNGLSVLSALFVQVLDKRSQMRLCTAPSTFKPPPRVTLTDTKREAWLKDLANPEVPLRKLSRTIPHGIRGKVLLDHCISKDIPIARAVWLSKCVGANEIRAFKRKGVSGPAALAGELKWIREWTVFVEQFVDGVIASCGQPGWSRKMNYAVRLGTQFYVDHLLDEEHYMDWILASLKQSSPERLPVWILLIQIYWKHLISHRNRGRRLAEALLGHAKALAATPYGINLQLTTRINQLISLLAVNHRGCLVLPKSWIEYKATFSAVKPTGRVNVEAESLINVTRRNNRLSGASPQATSRTPRLRLLDILDSVGLDVHVDKIAARCELLGLDTRSMLVTILEWAASKHRSGIARVYLAAQLIRYWSFAGFSADDAVLTMLEKARNDRNMEPRLIYKLVSALARSGHFSVGRYLQWLISTGVLSGSNAAASEAQLLLELPTAYLSSHIVNLRRTLLNRVGYNAYAETREIENYKTVLSQHLGGMSLPSPGVAFQEPILTSKPVGAVKMAVAQWLCERVISQNFESVSDTVFNGNLAAFCLVRHTLEQFEDYPSLAKVLAAASSCNNPQILAATADTVNLNIEVFATMGFLPALVSQIYQQQRRLRAKQPLDRSFLLSLAGLVRRVPAGVAYGKVLDSELATCEIQSSTAACSPASDSMALSHSGSLESNEDIDRVLTSGNTMDEQLLVRMFTTIADRSVKMGPDGLSRASTWFMQLRSFDQTSFEQLVHKLVTRMAEAAAPYEAVEGVVVSLVGSSCLKLDTFHQIWEKKLNAIKATEPANATRIATICAKILIPSTSMGLNQSAEAYRFKVAQNMFCLDQKASILRLIGSLLQLNPQSILSKNGNETGDKVVSWLRRYVVMDSKLVSNELVCKDNPMISQNTVQPLLDSLLDPAPQAEKASMSIIDKVNKIVQSTTELSLPFSQIALQQLSSALSGGSSLSDNDKTSLVRTFQSAIEHTSSSWPQLLGALDKDLIHHIHSWAGECVLEKLSSIITADGSMAEEAAVRRYLKAVESSALAASSQFMPSTAFSMLVEYLKRLGQFVEGINPLDPTHSDRKLRMAFGISVLLQLTTMQFHTLHDANALAQDLIPLMGVLCALLIHPKLQSQQTILEHILDVASMISDDLSHEHLHTILRNLPPQARCIPRLRYLFGTHTSPDAWLSLASKVVPASAAQQNPTSTPLQVSSSPVSATQSPSMLQRPWPVPARPGMPARPPSTATTPVLSQAHLQQQQVQQQRLSMGIGANRGPVELKQTPYMLRRWELMPDPTPIMGANDTSLSLGLFQARKCV
Length1476
PositionKinase
OrganismAureobasidium namibiae CBS 147.97
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.06
Grand average of hydropathy-0.129
Instability index48.54
Isoelectric point9.31
Molecular weight162406.15
Publications
PubMed=24984952

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01070
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     183.84|      43|      58|    1361|    1403|       1
---------------------------------------------------------------------------
    3-   27 (27.76/10.33)	............SQPSAGTQVPG....PH...PRPlNRPALPSK...
 1361- 1403 (84.40/48.24)	QQNPTSTPLQVSSSPVSATQSPSMLQRPW...PVP.ARPGMPARPPS
 1421- 1464 (71.68/39.72)	QQQRLSMGIGANRGPVELKQTPYMLRR.WelmPDP.T.PIMGANDTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.42|      39|      58|     997|    1037|       2
---------------------------------------------------------------------------
  997- 1037 (61.87/40.01)	VAQNMFCLDQ....KASILRLIGSLLQLNPQSilSKNGNETGDKV
 1052- 1094 (60.54/33.73)	VSNELVCKDNpmisQNTVQPLLDSLLDPAPQA..EKASMSIIDKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.05|      28|      58|    1113|    1143|       3
---------------------------------------------------------------------------
 1113- 1143 (39.70/39.59)	LQQLSSALSGGSSLSDNdktSLVRTFQSAIE
 1173- 1200 (44.35/33.91)	LEKLSSIITADGSMAEE...AAVRRYLKAVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.03|      62|     166|      67|     182|       4
---------------------------------------------------------------------------
  106-  182 (96.62/135.29)	KPT......PAPVLDPSTRANGLH..PPAVATKLPRDKAADFFPWTNIegkhpeDVlneHLiksgfsDKPAG....................ASQQESNMARPHL
  454-  543 (81.41/32.43)	KPTgrvnveAESLINVTRRNNRLSgaSPQATSRTPRLRLLDILDSVGL......DV...HV......DKIAArcellgldtrsmlvtilewaASKHRSGIARVYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     348.48|     116|     512|     271|     412|       7
---------------------------------------------------------------------------
  271-  412 (175.86/156.95)	PIARAVWLSKcvgANEIRAFKrKGVSGPAALAGELK..WIREWTvfveqfvdgviASCGQPGWSRKMNYAVRLGTQFYVDHLLD.....EEHYMDWILASLKQSSPERLP.......VWILLI....QIYWKHLIsHRnRGRRLAEallghakalAATPY
  794-  927 (172.62/102.48)	PLDRSFLLSL...AGLVRRVP.AGVAYGKVLDSELAtcEIQSST...........AACSPASDSMALSHSGSLESNEDIDRVLTsgntmDEQLLVRMFTTIADRSVKMGPdglsrasTWFMQLrsfdQTSFEQLV.HK.LVTRMAE.........AAAPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01070 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MISQPSAGTQVPGPHPRPLNRPALPSKLSNVNLSRQDDIADVDEANRSAYTANGMLQYAAQPVNTPDEPTQHIPPRLLSHRTTQLPLPRRPQSLTAQGQSRTIIPKPTPAPVLDPSTRANGLHPPAVATK
2) SAAQQNPTSTPLQVSSSPVSATQSPSMLQRPWPVPARPGMPARPPSTATTPVLSQAHLQQQQVQQQRLSMGIGANR
3) VLNEHLIKSGFSDKPAGASQQESNMARPHLW
1
1358
153
130
1433
183










Molecular Recognition Features






MoRF SequenceStartStop




1) YMLRRW
1443
1448