<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01069

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMTLRLDRSFLPSHGSLGGFPSAAVSSSAKALTAVFTHTNRPTSKQRRRQSPSFDHRPASTSTSIVASSPSPSHRPPPATSPIDSPVARMPTSPASPPYYYQNQPVIHKAAPVSVAPHTPPSPASVRMSSSAHNGKDQSFPTPPSSYVPTSSHSFAGMNTHNSTPQHSMDTDMPDAEAPQARPTLPLLCQSLCRIAHPISRPHPNENLINLYGLQSIANSVRRTDPITGEKINKLRKSYEGKVKNFGLTGKNKPTDLNEELRGLLQWDPESWYDQRVHGRELDKAESSPLMATLGRALTMNPGTLPADEHNKWKSILGLDDGNKTPSQPASKIPAHSQMLKAQASSMRASAPASPRASNPNGIRPDRSNKKRRYDESSYTGYNESYQEDDGYSTGGLDDKRNSATKKRRKV
Length410
PositionHead
OrganismAureobasidium pullulans EXF-150
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.05
Grand average of hydropathy-0.889
Instability index72.67
Isoelectric point9.88
Molecular weight44692.31
Publications
PubMed=24984952

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01069
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.89|      20|      20|      50|      69|       1
---------------------------------------------------------------------------
   50-   69 (35.67/15.54)	SPS..FDHRPASTSTSIVASSP
   95-  116 (26.22/ 9.47)	SPPyyYQNQPVIHKAAPVSVAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.40|      19|      20|     181|     200|       2
---------------------------------------------------------------------------
  181-  200 (30.90/26.44)	RPTLPLLCqSLCRIAHPISR
  204-  222 (31.50/21.42)	NENLINLY.GLQSIANSVRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.85|      18|      20|     118|     136|       3
---------------------------------------------------------------------------
  118-  136 (28.63/18.81)	TPPSpASVRMSSSAHNGKD
  141-  158 (34.22/17.98)	TPPS.SYVPTSSHSFAGMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.00|      16|      20|     315|     330|       4
---------------------------------------------------------------------------
  315-  330 (27.78/16.06)	ILGLDDGNKTPSQPAS
  338-  353 (24.22/12.94)	MLKAQASSMRASAPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.51|      30|      32|     238|     268|       5
---------------------------------------------------------------------------
  238-  268 (48.91/32.69)	YEGKVKNFGLtGKNKPTDLNEELRGLLQWDP
  272-  301 (51.61/30.29)	YDQRVHGREL.DKAESSPLMATLGRALTMNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01069 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QRVHGRELDKAESSPLMATLGRALTMNPGTLPADEHNKWKSILGLDDGNKTPSQPASKIPAHSQMLKAQASSMRASAPASPRASNPNGIRPDRSNKKRRYDESSYTGYNESYQEDDGYSTGGLDDKRNSATKKRRKV
2) SAKALTAVFTHTNRPTSKQRRRQSPSFDHRPASTSTSIVASSPSPSHRPPPATSPIDSPVARMPTSPASPPYYYQNQPVIHKAAPVSVAPHTPPSPASVRMSSSAHNGKDQSFPTPPSSYVPTSSHSFAGMNTHNSTPQHSMDTDMPDAEAPQARPT
274
27
410
183










Molecular Recognition Features






MoRF SequenceStartStop




1) SPPYYYQNQPVI
95
106