<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01067

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKSCWTNLQAVEGYSHIDYLIYSHQDATDGDKGLWDDLELRNDLLLGLRQRKVLVQSAVAQKKVCVFGGFKAADEYMKEVGWKVHQQGRLEAALLTRANNDPKNVMQNQHIFTMFLAAVEASLSISLSTLCGAVRVGHLTWIIPTEGDYQLLSLRAQMTSQGTLALLPHASNTGLSTASEKDGTNVILAPSGTPATIASSLSDLALNDDAPPYQARREARMRLSRRAKDDSWKDNATTKLRQSSLPHDESWLRVSLRSSTSSEQVACLWPGPLCLEIPSRQSPPSIHDTDSMQWFDSKNPYDDPLNTAESWFLGQEERADLEKKTLQAEKDKTAVANNPPDEPISDHLSVTSPVYSRSIQDQISVNGIYPTPPDAVPPIICADPSIPSVIVSDNPIEALPGLPEDNPDQDQDQDMRRNSNTSDVDIDTEHYRKGSTDDLFNDVDEEMFGNPDVTDADFSFFDNPGGLHAMPAMPTISGPPEDMTDVLPDPTPKPEPDMYHPPPIQLEPEENIPEEPVKIQDKQDSDIKVEEVPEEIASTPPLSPLKIKERLLPSGEGEANVIGLRRDSTFLPVVFKGDVINFDAKYRTLGKFDSKLTKKSENANRSNSIALPEKPFRTRMVKPLSQGRATVAVTKFTPRDDDISYQDSELETSQESDSDSDSISSVEGSLRSLDIRKRKRISADEGPTPRLLAESVVESDVESIVSDATAMADPGPIIDQLVAAKESGNRITEQQHKFSDNLSMWRTPSKTLPSNQDLNIWSVLDFTADDLVDIAQLVAEQSTFSTSSSLESSMNPTVGSPVYYTAQDALRQVFEKAQDCDFAKVGAMAAHHAEQAIAAAAKSQQRPIPRRPGTVNSVITIPAPAVHVRRANQGWELQPTAVSFWETLGLEPAHGPKDVVAFALYPDSGVVCEAVADFMHDVRLAYENRKFGFHHVGGETSEHEDGLMPYKSHGETSVVNILQGIQTACNALGDLLHDAELEDPIIIYMVDPFQDESMTKYLCGCFQAMLIAYSSDREDPPPLILQIIPMSRIACPTALIVPDQIWLASLASFIYDRVPAMEKNNQNSAWHKSSSPSIHLATPPSRKINFALTERTPRNLLEEAQILHLAYAVNADNSWLSAAWTDNTGRHQYRASYCLSNTDGRVVLNELRDTTLALTRTSHWRIFVARAGVMRDWEKRIWRERPSETWSIALLDVDISPSLQVGANTDVAGQGQAAFMTPAATPQASAFTSPEGGAQGTTPTAGETPQQTVLESQQQQMPDPDAFLIDNTDETWGVLMPFSCTRSTTLSRPLASGLLLKRGSSSSAGTDPSANFPSLAVDLMDVMPPRLLDGTPSWLTQRAPETVLKECLVWFRGLGLLGKIRSVPGCEAGNVPWHLGVAIQGVDALTGFLE
Length1397
PositionKinase
OrganismAureobasidium pullulans EXF-150
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.06
Grand average of hydropathy-0.402
Instability index49.46
Isoelectric point4.79
Molecular weight153523.29
Publications
PubMed=24984952

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01067
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.49|      13|      17|     231|     246|       1
---------------------------------------------------------------------------
  231-  246 (18.60/20.11)	KDDSWkdnATTKLRQS
  250-  262 (23.89/14.83)	HDESW...LRVSLRSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.35|      40|     395|      29|      75|       2
---------------------------------------------------------------------------
   29-   75 (59.17/50.83)	DATDGDKGLWDDleLRNDLllglrQRKVLVQSAVAQKKVCVF...GGFKA
  430-  472 (68.18/41.17)	DTEHYRKGSTDD..LFNDV.....DEEMFGNPDVTDADFSFFdnpGGLHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.81|      24|     791|     477|     502|       5
---------------------------------------------------------------------------
  477-  502 (43.00/27.19)	PTISGPPEDmtDVLPDPTPK.PEPDMY
 1246- 1270 (38.81/18.46)	PTAGETPQQ..TVLESQQQQmPDPDAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     276.33|      66|     408|     348|     413|       6
---------------------------------------------------------------------------
  348-  413 (118.81/54.49)	SDHLSV.TSPVYS.RSI....QDQISVN.GIYPTPPDAVPPI..ICADPSIPSVIVS.DNPIEALPGLPEDNPDQD
  661-  722 (73.05/30.98)	SDSDSI.SSVEGSlRSLdirkRKRISADeG..PTPRLLAESV..VESD..VES.IVS.DATAMADPG.....PIID
  742-  811 (84.47/36.85)	SDNLSMwRTPSKTlPSN....QD.LNIW.SVLDFTADDLVDIaqLVAEQSTFSTSSSlESSMNPTVGSPVYYTAQD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01067 with Med13 domain of Kingdom Fungi
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