<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01063

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMANTWNGTPLDEVQFRRPDVIGWWGINENSIHAILRETPFFDPTSKNGLLWKQAEVHPPIWEMCTNRQAFETRLKQMNGVEYLIVGEPQPNTDPALGPDTGIWVIRKQDRRKRPPQADEITVLATYYMVGENMYQAPSVYDIVGNHLLSAMNSLTKFTQAAAPLPLYAPATGYTYFPPATAKSLAASQALTATSREASTAPTPAEIPPTATLEPTAQPTTSTLESKATTKDADPRAQKAFYESLHNMVLYGDEYMDENPLRGEPGNFTFSATKHHVRAKAEAAEAAKLKEAELARKLEEARLAAKATPFASAAAKKDEEEKTKKKVRDKIKKRRSKGLATNPSTPASPATPAA
Length353
PositionHead
OrganismAureobasidium namibiae CBS 147.97
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.08
Grand average of hydropathy-0.603
Instability index42.87
Isoelectric point8.68
Molecular weight38849.49
Publications
PubMed=24984952

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364143
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01063
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.51|      25|      41|      61|     101|       1
---------------------------------------------------------------------------
   61-   87 (40.39/59.95)	WEMctNRQAFETRLKQMNGV....EYLIVGE
  103-  131 (41.12/19.00)	WVI..RKQDRRKRPPQADEItvlaTYYMVGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     201.19|      40|      41|     271|     310|       3
---------------------------------------------------------------------------
  179-  224 (40.72/17.21)	ATAKSL.AASQALTATS.REAST..APTP..AEipptATLEPTAQPttstLE
  227-  268 (54.71/25.40)	ATTKDADPRAQKAFYESLHNMVLygDEYM..DE....NPLRGEPGN....FT
  271-  310 (57.65/27.12)	ATKHHVRAKAEAAEAAKLKEAEL..ARKL..EE....ARLAAKATP....FA
  313-  353 (48.11/21.54)	AAKKDEEEKTKKKVRDKIKKRR...SKGLatNP....STPASPATP....AA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01063 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASQALTATSREASTAPTPAEIPPTATLEPTAQPTTSTLESKATTKDADPRAQK
2) DEYMDENPLRGEPGNFTFSATKHHVRAKAEAAEAAKLKEAELARKLEEARLAAKATPFASAAAKKDEEEKTKKKVRDKIKKRRSKGLATNPSTPASPATPAA
186
252
238
353










Molecular Recognition Features






MoRF SequenceStartStop




1) IWVIRK
2) KKDEEEKTKKKVRDKIKKRRSKGLATNPSTPAS
102
315
107
347