<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01057
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MADMTLPSSLLQPRDDNDADSILSILGRIHDERGHFRHITEQSLQAEIAANENDEESSETDDEDDGAEADTAEEKDRREQLWVARAEMRQHVDSARNEALIALDFVSLLISKDAPKQADLTMSPHLKQFIKPGTLAMDVWHNVPPNKDQEKVDDTIARGWRMQSLQASADSLLGAATRLEKNVRKETHYWEQVLSVSDKGWSVSRLPREKHNLGVRFGFLEALGEFRDRGLAALRSDEDGNVLLDKGVGNNSKVIRVRIRKGDDIVGVSQMPNVSAESESALEARIRHARDSLYEEELFHEIIRESRSLSSYGVDMRESTIRLPTRLSSVESSAVSEAHEVLIDLLPLTDIETKAQKKQPDDAWAQAIALALRLFLSYTHRERLIHRSELPPPMSSARKETPVASIMRPVLTLLQHRSVLTDIDAYLERIKKLLDTASVDTSIETAAFDPALLRSAETIDTLMQRGLAPLHSRMRISVKTAHLPEALDFGIEVRTSISPPAFGSAMLVTSPIGLSRVEIPDMEELKDYLNTAIANALGHGIVDKLSDWSLNDRCGILGKANSNDKISIEVRGAKDAAQDGLVLRTPGQVFEWKVEDDEMKQKGFWETVNQSVWNGA |
Length | 616 |
Position | Head |
Organism | Aureobasidium namibiae CBS 147.97 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes>
Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.447 |
Instability index | 43.02 |
Isoelectric point | 5.15 |
Molecular weight | 68768.63 |
Publications | PubMed=24984952
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP01057
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.50| 26| 147| 19| 44| 1
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19- 44 (46.18/30.10) ADSILSILGRIHDERGHFRHITEQSL
169- 194 (42.32/26.99) ADSLLGAATRLEKNVRKETHYWEQVL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.00| 31| 34| 417| 448| 2
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417- 448 (46.29/40.67) RSVLTdIDAYLERIKKLLDT..................ASVDTSIETAAF
454- 502 (43.71/32.35) RSAET.IDTLMQRGLAPLHSrmrisvktahlpealdfgIEVRTSISPPAF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.23| 25| 38| 277| 303| 3
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277- 303 (36.06/28.16) ESESALEARIRHARDSLYEEElfHEII
318- 342 (39.17/23.81) ESTIRLPTRLSSVESSAVSEA..HEVL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.90| 17| 383| 88| 105| 4
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88- 104 (27.52/20.05) MRQHVDSARNEALIALD
122- 138 (30.38/16.51) MSPHLKQFIKPGTLAMD
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