<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01055

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMENIDVDELFGEESINAAIAATFDTDALFQRIERSHIVGCCQRLAWSRTSCIAQISADSRKVVVRALCRDKNTANWSLSDETEVNASEGAIFTHVEWSSSGFDLVIADQFGRFTLFSLTHALNSLERRPVNLTSSVDDLNQVVGLHWLPTNPAGQTRTALILPAAKEGNRWVNTMKLHEVHGVSNPIDNKAAFLCVTRRGLLKLIYEQPGQPWSQYVFTLDNLADSGDVLTHAAFCQANQHLVMVTYDTSKRLRLYKIMINWNANAGDGTNHKTTLNPQIAVLHVELLDRCVPQSSERAASAQLSSLHVEPISQAIDNSTFTVVAVFTSAAQDHSGKFSIISRWDLQQVDATLHDSFKSLRPTTAQPATNKPVQRLYRTEDIFSQKAILALQSNVYHNMFAFAASDGTVEFRSRETMQIIISDGDTNKATSLPQNGFSFPNEDCIDIFLSPSLAASVITKPDGTLKLHNAEYQHNWKDAKDDNDLAQAAVVSLARELASVTCYQIGFDDLLSVIPTDLDRSLRCKFISEIFRTISRNVDFSLDDPKLQSGKVLKDSLLFRIASAQLLVSYNTNPKRRDIPAKSAWVLLNLRSVCTNIAQTLTMTQQIRGMHNMESSLFVSLKGLVRWSLDLMTLIFDDMIETMRFCKGDFDRGRILAYIHEKNSVSLHILLCSTTRALLGMLGNLIRNFAMRVVKTQEKVRLSSRTNDIRDSVELQQMEAMMGSELPFEIKLFEQLVAEVDGNVRATYQAAQSSPPHRSFYEQSMLVDADIPEALSPVLQRLFGEIVPRLESQIDGVAIYLRDTAWLDLGEDEEAIKRAERQQYDVLRKCAIPPNAKVRQCRRCGSVIENLTDGHMAAWVQNAHKMCICLSHWTVV
Length876
PositionTail
OrganismAureobasidium namibiae CBS 147.97
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.07
Grand average of hydropathy-0.167
Instability index42.44
Isoelectric point6.05
Molecular weight98178.67
Publications
PubMed=24984952

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01055
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.38|      26|     213|     397|     423|       1
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  397-  422 (42.73/29.16)	HNMFAFAASDGTVEFRSRETMQIIIS
  425-  450 (44.65/25.49)	DTNKATSLPQNGFSFPNEDCIDIFLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.32|      17|      22|     279|     295|       3
---------------------------------------------------------------------------
  279-  295 (29.65/19.35)	QIAVLHVELLDRCVPQS
  303-  319 (28.68/18.49)	QLSSLHVEPISQAIDNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.48|      19|      20|      75|      93|       4
---------------------------------------------------------------------------
   75-   93 (33.40/20.58)	NWSLSDETEVNASEGAIFT
   96-  114 (35.08/21.95)	EWSSSGFDLVIADQFGRFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.00|      25|      47|     643|     668|       7
---------------------------------------------------------------------------
  643-  668 (40.19/30.94)	MRFCKGDfDRGRILAYIHE.KNSVSLH
  691-  716 (35.82/22.00)	MRVVKTQ.EKVRLSSRTNDiRDSVELQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01055 with Med16 domain of Kingdom Fungi
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