<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01054

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKSCWTNLQAVEGYSSIDYLIYNHQDATQGQKSDWDDADHRNEVLLGLRQRRVLVQSAVQQKKVCVFGGFQAADEYMKSLGWQVHQRGRLEAAALTRANSDPKVVVQNQHIFSMFLAAVEASLSISLSQLCGAIRVGHLTWILPADGDHQLLSLRAQMTSQGTLALLPHANNTGLSIASETDGVNILLAPSGTPATIASQLDKIDGNDGASTYQARREARMRLSRRAKHENWKESAATKLEQSNLLHNESWLKVSLRPSADQDQVECLWPAPLCLEIASRQVPPSLNRADSMRWFDSKDPYQNPLDTAESWFLGQEERASQEQKMRQAEKEKENAANNLSDEVIPDHLSVTSPLYSRSIQDQISVNAIYPTPPDAIPPIICADPSIPNVIVSDNPIESLSSLNEELQDQDQDQDMRRNSNTSDVDLDTEHYRKGSTDDLFGDGDEEMLGNPGVTDADFSFFDNPGGLNSLPPVTGHLQEMEDAIPDPTPKSEVVMLQQQPDTAEPEDHIPQWDLVTSHMKEEEPIVKMEDLAEENVTTPLLSPLMIKERLLPTDNEEKSVPKFRRDSTFLPVVFKGDLSDFDAKYRTLGKFDGRFVKKDEIANRSSSIALPPKPVRARTFNPLSRRRATLAETKFTLKDEGALQQDSESETSQESETESMSSVEGSLRSLDIRKRKRGSADEGPTPRLLAESIVESDVESVMSDATAMADPGPVIDQLASARESQNRVTEQQHKFSDNLSVWRAPSRSVPPSQDLNIWSVLDFTADDLVDIAQFVAEQSTFVEVSEDDAAYSPTVVSPVYSTAQDALRQVVAIAAAAKSQQRPVPRRPPGTVSSVITIPAPAVQVRRAGQGWELQPTAINFWDTLGLEPAHGPKDVAAFVLYPDSGVMGEAVADFVQDIRLAYESRKFGKHFVGGETGEHEDGLVPYRSHGEASVVNILRGLQTACNALGDLLHDADLEDTIVIYMINPFQDDSIIKYLCGCFQALLIAYSSDREDPPPLILQIVPMNRIACPTAMIVPDQSWLNSLAAFIYDRVPLDTPTDHASFWPLNTCPSIHLGTPPSRKINFALTDRVSRNLLEEASILHVAYAVNADNSWLSAAWTDNTGTHCHKASYCLSNTDGRIILTEVRDTTLSLCRNNPHRILVARAGVMRDWEKRVWRERPGESWSIGLLDVDVSPALQVSANTEGNNGPGGQGLWTPAATPQASTFTSPEGVDTKPSTPVETPNSAANLNTQQELQQQQIDPEAFLIDNTDETWGVLMPFSCTRATTLSRPLASGLLLKRGAHDSTANLPSVAIDLMDVIPPRISDTGVNWLGFRAPETVLKECMVWYRGLGLLGKLRGVGGCKEGVNGNGSVPWHLGVAMSGADALQGFLE
Length1378
PositionKinase
OrganismAureobasidium namibiae CBS 147.97
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.06
Grand average of hydropathy-0.397
Instability index50.59
Isoelectric point4.81
Molecular weight151607.97
Publications
PubMed=24984952

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP01054
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.68|      39|     146|     381|     422|       1
---------------------------------------------------------------------------
  381-  422 (63.98/40.46)	PII.CADPSIPNVivsDNPIESLSSLNEELQDQDQDQ....DMRRNS
  527-  570 (55.71/28.80)	PIVkMEDLAEENV...TTPLLSPLMIKERLLPTDNEEksvpKFRRDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.93|      18|     314|     668|     689|       4
---------------------------------------------------------------------------
  668-  687 (25.74/23.96)	GSLRSldIRKRKRGSADEGP
  699-  716 (31.19/13.91)	SDVES..VMSDATAMADPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.06|       8|      18|     289|     298|       6
---------------------------------------------------------------------------
  289-  298 (12.34/12.61)	LNRADSmrWF
  308-  315 (16.72/ 8.31)	LDTAES..WF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.91|      18|      18|     480|     497|       7
---------------------------------------------------------------------------
  480-  497 (32.76/16.02)	LQEMED.AIP.DPTPKSEVV
  499-  518 (27.15/12.07)	LQQQPDtAEPeDHIPQWDLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.60|      55|     101|     220|     275|       9
---------------------------------------------------------------------------
  220-  275 (92.12/61.40)	REARMRLSRRAKH.ENWKESAATKLEQsNLLHNESWLKVSL..RPSADQDQVECLWPAP
  318-  375 (82.47/50.38)	QEERASQEQKMRQaEKEKENAANNLSD.EVIPDHLSVTSPLysRSIQDQISVNAIYPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.89|      21|     103|     758|     778|      10
---------------------------------------------------------------------------
  758-  778 (37.27/21.74)	LNIWSVLDF.TADDLVDIAQFV
  862-  883 (35.62/20.43)	INFWDTLGLePAHGPKDVAAFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.84|      25|     747|     451|     476|      12
---------------------------------------------------------------------------
  451-  476 (43.61/24.94)	LGNPGVTdADFSFFDNPGGLNSLP..PV
 1200- 1226 (43.23/20.64)	LWTPAAT.PQASTFTSPEGVDTKPstPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01054 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DTAESWFLGQEERASQEQKMRQAEKEKENAANNLSDEVIPDH
2) ESVMSDATAMADPGPVIDQLASARESQNRVTEQQHKFSD
3) IVSDNPIESLSSLNEELQDQDQDQDMRRNSNTSDVDLDTEHYRKGSTDDLFGDGDEEMLGNPGVTDADFSFFDNPGGLNSLPPVTGHLQEMEDAIPDPTPKSEVVMLQQQPDTAEPEDHIPQWDLVTSHMK
4) KFTLKDEGALQQDSESETSQESETESMSSVEGSLRSLDIRKRKRGSADEGPTPRLLAESIVE
5) LQVSANTEGNNGPGGQGLWTPAATPQASTFTSPEGVDTKPSTPVETPNSAANLNTQQEL
309
702
393
637
1183
350
740
523
698
1241










Molecular Recognition Features






MoRF SequenceStartStop




1) IRKRKR
675
680