Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLSVFQTRFQRLETALNTLVESVAAYNPSISAANALVAADDELDESLEQLAVHHANYSRILELRATADALDEKIKSTLRTLADTRKELLDIPSSQPAPNTRQVGVEELLSYAKFISKTTVPPTFRGHISTDLLSQPQPAVTDAPTTQITNGMATPAHNGDNTSTTDHSATTENRAVATLSAETKAMLDPLSQLPFVPWPSQEVIRMGALAAIQGMLEDGTDPSTVLSAEEQEAADKRRAEEEERQQAEQEERERRRREDWAASGGNRAAITEDVFDPDEL |
Length | 280 |
Position | Middle |
Organism | Aureobasidium namibiae CBS 147.97 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.543 |
Instability index | 51.94 |
Isoelectric point | 4.59 |
Molecular weight | 30664.51 |
Publications | PubMed=24984952 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP01049 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 186.14| 38| 54| 131| 168| 1 --------------------------------------------------------------------------- 49- 77 (27.12/12.04) ......QLAVHHANYSRILELRATADALDEKIKST... 81- 109 (34.85/17.27) ..LADTRKELLDIPSSQ.......PAPNTRQVGVEELL 131- 168 (65.33/37.92) DLLSQPQPAVTDAPTTQITNGMATPAHNGDNTSTTDHS 188- 223 (58.84/33.53) DPLSQ.LPFV.PWPSQEVIRMGALAAIQGMLEDGTDPS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) QEERERRRREDWAA 2) RAAITEDVFDPDEL | 249 267 | 262 280 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab