<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01046

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKSCCTNLQAVEGYSSIDYLIYNHQDATQGQKTDWDDQDQRNDLLLCLRQRRVLVQSAVQQKKVCVFGGFQAADDYMKELGWQVHQRGRLEAAALTRPNSDPKLVMQNQHIFSMFLAAVEASLSISLSQLCGAIRVGHLTWILPTEGDHQLLSLRAQMTSQGTLALLPHANNTGLSIASDTDGANVLLAPSGTPAVVASPLNLTDINDNASSYQARREARMRLSRRAKHANWKSLAATKLEKASLSHDDSWLRVSLRSSNSQDQLECLWPGSLCLEIPSQQLSPSLDRTDSIHWFDSKDPYQNPLDTAESWFVGQEERANQEQKMRQAEKDKENAANNIPEEAIPDHLSVTSPVYSRSAQDQISVNGIYPTPPDAIPPIICADPSIPNVIVSDNPIEALPGLPEETQEQENDQHMTQNDSTSDVDLDTEDYHKENTDDLFGDADEEMFENPGVTDADFSFFDNPGGVASMPSITGPSEEMIDAVSDPTPKMEAVELQPQPTVLEENMPPEQIKSQEMQEETKKEPEKEDADVKLEDAIEEAASSPPLSPLKIKDRLLPEEQEEKHVPSLRRDSTFLPVVFKDDLSNFDAKYRALGKFDSGFVKKEDNANRSNSIALPEKPFRARNPTSLFRRRNTVAEAKFTPRDDGSQEESESETSQESDSESMSSVEGSLRSLDIRKRKRGSADEGPTPRYLAESIAESDVESVGSDATAMTDPGPMIDQLVAARESQNRATEQQHKFADNLSIWRMPSKSLTATQDLSIWPVLDFTADDLVDIAQLVAEQSTFAGASDLDIRETPTVASPIYSTAQDALRQVFEKAQDCDFARVGAMAAHHAEQAIAAAAKIQQRPVPRRPPGNISSVITIPAPAVHVRRAGQGWELQPTAVNFWDTLGLEPAHGPKDVAAFALYPDSGGLGEAVADFLQEIRLAYENRKLGKHYIGGETGEHEDGLVAYRSHGEPSIVNILQGLQTACNTLGDLLHDADLEDTIIIYMINPFEDESLVKYLCGCFQAMLITYSSDREDPPPMILQIVPMSRIACPTAMTVPDQAWLNSLAAFIYDRVSLESSNDQTSSWPLNLSPCIHLASPPSRKINFALTERTPKNLLEEAQILHVAYAVNADNSWLSAAWTDNTGIHYHKASYCLSNTDGRIILTEVRDTTLSLARDSPHRVFVARAGVMRDWEKRIWREKPSENWSIALLDVDMSPALQIGANTDGGGVLGMGAFMTPAATPQASTFTSPETGDTKPSTPAGETPTQQQELSSLQQADPDAFLIDNTDETWGVLMPFSCTRSTTLSRPLASGLLLKRGPSDSLSNLPSLAVDLMDVIPPRIPENAVSWLAQRAPETTLKETMVWYRGLGLLGKLRGVGECEEGNVPWHLGVVVKGAEALQGFLE
Length1395
PositionKinase
OrganismAureobasidium melanogenum CBS 110374
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.06
Grand average of hydropathy-0.459
Instability index53.08
Isoelectric point4.68
Molecular weight153522.63
Publications
PubMed=24984952

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01046
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.08|      12|      17|     512|     528|       2
---------------------------------------------------------------------------
  512-  523 (21.40/21.12)	PEQIKSQEMQEE
  552-  563 (20.69/ 6.02)	PLKIKDRLLPEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.60|       9|      19|     737|     750|       3
---------------------------------------------------------------------------
  737-  750 (12.53/20.47)	TEQQhkfadNLSIW
  758-  766 (18.08/10.09)	TATQ.....DLSIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.40|      11|      19|     621|     631|       5
---------------------------------------------------------------------------
  621-  631 (20.38/11.47)	EKPFRARNPTS
  641-  651 (20.02/11.13)	EAKFTPRDDGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.62|      18|      19|     164|     182|       6
---------------------------------------------------------------------------
  164-  182 (25.52/17.98)	QGTLALLPHAnNTGLSIAS
  185-  202 (27.10/14.30)	DGANVLLAPS.GTPAVVAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.72|      40|      91|     372|     414|       7
---------------------------------------------------------------------------
  372-  414 (65.53/43.13)	YPTPPD..AIPPIicADPSIPNV.IVSDnP...IEALPGLPEETQEQEN
  464-  509 (59.18/29.41)	FDNPGGvaSMPSI..TGPSEEMIdAVSD.PtpkMEAVELQPQPTVLEEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.30|      20|     606|     303|     333|       9
---------------------------------------------------------------------------
  304-  324 (33.52/33.53)	YQnPLDTAESWFVGQEERANQ
  594-  613 (35.78/ 9.75)	YR.ALGKFDSGFVKKEDNANR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.83|      10|     308|     718|     727|      10
---------------------------------------------------------------------------
  718-  727 (21.33/11.54)	DPGPMIDQLV
 1025- 1034 (21.51/11.70)	DPPPMILQIV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01046 with Med13 domain of Kingdom Fungi
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