<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01038

Description Uncharacterized protein
SequenceMISQPPTGTQVPGPHPRPLNRPALPSKLSNVDLNRQHDTADVDDTNHSAYTANGMLQYAAQSVNTPDEPTQHIPPRLLSQRTTQLPLPRRPQSLTAQGQARQPVPKPSPPPVLDPSTRANGLQPPAVATALPRDKAADFFPWTNIEGKHPEDVLNEHLIKSGYSDKPAGASQTESNIARPHLWPSLKNKNGLGVLSALFVQVLDKRSQMRLCTAPSTFKPPPRVTLTDTKREAWLKDLANPEVPLRKLSRTIPHGIRGKVLLDHCISKDIPIARAVWLSKCVGANEIRAFKRKGVSGPAALAGELKWIKEWTVFVEQFIDGIISSCGQRGWSQKMNYAVRLGTHFYVEHLLDEEHYMDWILTSLKQSSSEKLPVWILLTQIYWKHLISHRKRGHRLSEALLGHAKTLAGTPYGINLQLTTRINQLITILAVNHRGCLVLPKSWNEYKATFAAVKPTGRLNVEADGLINVARRNNRLSGASPQVTCRTPRLRLCDILDSVGLDVQIDRIAAQCEQLGIETRSMLVTILEWAASKHRSGIARVYLAAQLIRYWSFAGFGADDAVLTMLEKARNDRNMEPRLIYKLVSALARSGHFSVGRYLQWLISMGVLSGANAAASEAQLLLELPTAYLSSHIVNLRRTLLNRVGYHADAEAREVENYKAVLSQHLGGMSLPSPGVTSHEPVLSNNPVGAVRMAVARWLCERVVSQSFDSPNETVFIGNLAAFCLVRHTLEQFEDYPSLAKVLAAASTCNNPQILAAAADTINLNIEIFATMGFLPALISQIYQQQRRLRSRQPLDRTFLLSLSRLVRRIPSSVVYAKTLDSELAMCEIQSSTAACSPASDSMAISHSGSVESNDDIDRVLTSGNTMDEQLMVRMFTTIADRSVKMGSEGLSRASTWFAQLRSFDQTTFEQLVQKLVNRMAETIAPCETVEGVVASLVGSSCLKLENFYQVWEKKLNTIRSTEPANASRVAVICAKILIPSASVSHNQSAEAYRYKVAQSLFCLEQKAGILRIIGSLLQLNPQSVLPKNGNALGEKITSLLRQYIIKDRKLVSQELISKNNQLIAQGSVQPLLESLLDPVLQEQQVSIIEKVNQIVGSTTELSLPFSQVALQQLSSLLSGGNNLSETDKANLIRTFQNAIEHTSSVWPQLLGALDKDLIHHIHSWAGECILEKLSSIIAVDGSMEEETAVRRYLKAVEASALAASSHSMPSTAFIMLAEHFKRLGQFAENINPLDPAQSDKKARMAFGINVLLQLTTMHHHTLQDANAVAQDLIPLMGVLCALLIHPKLQGQQAILEHILDVASMISDDLLNEHMHTILRNLPPQTRCIPRLRYLFGTHTSPDAWLSLASKVVPAAAGQQNPTSTPAQPSSSPASATQSPSMMQRPWPVPARPGMPARPPSVPNTPVLSQAHLQQQQAQQQRLSMGMGANRGPVELKQTPYMLRRWELMPDPTPIMGANDTSLSLGLFQARKCV
Length1474
PositionKinase
OrganismAureobasidium melanogenum CBS 110374
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Dothideales> Saccotheciaceae> Aureobasidium.
Aromaticity0.05
Grand average of hydropathy-0.175
Instability index50.89
Isoelectric point9.21
Molecular weight162437.94
Publications
PubMed=24984952

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
	.uniprot.org/unirule/RU364129' style='color:#FF0000;'>RuleBase:RU364129
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP01038
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     235.67|      75|      75|     937|    1011|       2
---------------------------------------------------------------------------
  937-  989 (75.67/51.59)	..............................LVGSSC.LKLENFYQVWEKKLNTIRSTEPANASRVAVICAKILIPSASVSHNQS
  990- 1062 (110.18/79.14)	AEAYRYKVAQSLF..CL.EQKAGIL....rIIG.SL.LQL.NPQSVLPKNGNAL.GEKITSLLRQYIIKDRKLVSQELISKNNQ
 1065- 1125 (49.82/30.96)	AQGSVQPLLESLLdpVLqEQQVSIIekvnqIVGSTTeLSLP.FSQVALQQLSSLLSG.GNNLS.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.10|      23|      64|      52|      74|       3
---------------------------------------------------------------------------
   52-   74 (43.16/24.74)	ANGMLQYAAQSVNTP.DEPTQHIP
   96-  115 (36.69/19.79)	AQGQ...ARQPVPKP.SPPPVLDP
  119-  141 (33.24/17.15)	ANG.LQPPAVATALPrDKAADFFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.30|      48|     133|    1168|    1238|       4
---------------------------------------------------------------------------
  879-  928 (80.88/38.32)	IA.DRSvkMGSEGLSR.......ASTWFAQLRSFDQTTFEQLVQ..KLVNRMAETIAPCE
 1178- 1235 (66.42/55.46)	IAvDGS..MEEETAVRrylkaveASALAASSHSMPSTAFIMLAEhfKRLGQFAENINPLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.30|      22|     133|       9|      30|       5
---------------------------------------------------------------------------
    9-   30 (41.99/23.00)	TQVPGPHPRP.LNRPALPSK.....LSN
  143-  165 (32.50/16.05)	TNIEGKHPEDvLNEHLIKSG.....YSD
  171-  196 (24.80/10.41)	SQTESNIARP.HLWPSLKNKnglgvLS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.78|      41|      63|    1359|    1401|       6
---------------------------------------------------------------------------
 1359- 1401 (71.87/38.79)	QQNPTSTPAQPSSSPASATQSPSMMQRpW...PVPArPGMPARPPS
 1419- 1462 (73.91/32.78)	QQQRLSMGMGANRGPVELKQTPYMLRR.WelmPDPT.PIMGANDTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.00|      39|     126|    1134|    1174|       7
---------------------------------------------------------------------------
 1134- 1174 (62.51/40.15)	RTFQNAIEHTSSVWPqLLGALDKDLIHHiHSWAGECILEKL
 1261- 1299 (67.49/35.60)	HTLQDANAVAQDLIP.LMGVLCALLIHP.KLQGQQAILEHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.82|      23|      77|     386|     411|      17
---------------------------------------------------------------------------
  386-  411 (35.42/22.91)	LISHRKRGHRLSEAllgHAKTLAGTP
  466-  488 (41.41/20.06)	LINVARRNNRLSGA...SPQVTCRTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01038 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAGQQNPTSTPAQPSSSPASATQSPSMMQRPWPVPARPGMPARPPSVPNTPVLSQAHLQQQQAQQQRLSMGMGANRGPVELKQTPYMLRRWELMPDPTPIMGANDTS
2) MISQPPTGTQVPGPHPRPLNRPALPSKLSNVDLNRQHDTADVDDTNHSAYTANGMLQYAAQSVNTPDEPTQHIPPRLLSQRTTQLPLPRRPQSLTAQGQARQPVPKPSPPPVLDPSTRANGLQPPAVATAL
3) VLNEHLIKSGYSDKPAGASQTESNIARPHLW
1355
1
153
1462
131
183










Molecular Recognition Features






MoRF SequenceStartStop




1) LRYLF
2) YMLRRW
1332
1441
1336
1446