<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01018

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMDQSQNQRSITTTTSQSRSLQFHPARVPILDLFNLYLGLGRNSRNKPDDSIREPPNKTQKRVHAINRELPPPNEQFIVDFEQLQSQFPDHEQLRSVTEAILIPLVVQCSGHGPRSDFLLFVLRSLCGIGCINWDTFLPALVSSVSSAEIPVGQTSQAVSTVTSSSLSQSGMLPPPSTIANSSNFQSSNPASPLTSVHTIGSPAQSSIEPLSCAALSPVKSSDISSAGQQSKQRGSPSVRNNDISYSSLRQLCCKIILTGLEFSLKPMTYAEIFNHMLNWLVNWDQGQQGVDESDNQKSWRPDNALVAWLHSCLDVIWLLVDEGKCRVPFYELLRSDLQFMENIPDDEALFTLILEIHRRRDMMAMHMQMLDQHLHCPTFGTHRILNQTTPTISGEGIAHLRLSPISYLSVLGEPLNGEDIAISIQKGSLDWERAVRCIRHALRTTPSPDWWRRVLVLASPYRPSAQGPTAGAVFSTEMICEATIDRIVELLKLTNSEINCWQEWLVFSDIFYFLMKSGCINFVDFVDKLVSRLAEGDHHTLKTNHVTWLLAQIIRIELVMTALNSDSRKVETTRKVLSFHREDRSSDPNSPQSILLDFVSSCQNLRIWSLNTSAREYLNNEQLQKGKQIDEWWRQASKGDRMMDYMNMDERSIGMFWVVTYTMAQPALETVMNWLTSAGVIDLAPATNLQPPERLVCTREVNPLPMSLISGFSMNLCLKLSYQMEDSLFSGQVLPSIAMVETYTRLLLIAPHSLFRSHFIHLGQKSPSLLSRPGVTLLVLEILNYRLLPLYRYQGKSKALMYDVTKIISALKGKRGDHRVFRLAENLCLNLIFSLRDFFLVKREGKGPTEFSETLNRVTVVTLAILIKTRGIADADHLPYLQNMLEQIMATSVHTWSEKTLRYFPSVLREALSGRPDKRSLAIQTWQQAEQTVIHQCNQLLSPSADSNYVMTYINHSFPQHRQYLCAGALILMQGHAENINSGNLGRVLREFSPEEVTSNIYTMVDVMLHHMQIELQQGHLIQDLMLKAISSLAFFVWTNEILPLDILLLALTDRDDDPHALRIVISLLDRQELQQRVKLFCLTRGHPEHWLYTGMFKRVELQKALGNHLSWKDRQPVYFDDIAARLLPIIPLIIYRLIENDAMDTAERLLALYSPLLAYYPLRFTFVRDILAYFYGHLPGKLIVRILNVLDISKIPFSESFPQQISSPNPAMCPPHDYFTTLLLGIVNNVIPPLHNNSKSGSIGDSSNGAQRTSQSKPPAVSQSGPANASESQKAFYQIQDPGTYTQLVLETAVVEILSLPVSASQIVQSLVQIVVNIQPTLVQSNDSFNGSSNGVGQGSVLPTSPSGGSTDSIGASRSTPSTSGVNTTNFASRSGYTCQQLSCLLIQACGLLLAQLPSDFHSQLYLETTRIIKENWWLTDVKRSLAEIDSAVGYALLDPTWAAQDNTSTAIGNVVALLHSFFSNLPQEWLEGTNVIIKQLRPVTSVAMLRIAFRIMSPLLPKLANAHALFNKTLSILLSVLVDVFGKNSQTSTAVDASEIADIIDFLHHVIHYEGQGGPVQASSKPRPDVLALIGRAAESLRPDIQHLLSHLNTDVNSSVYAASHPKLVPNPT
Length1615
PositionTail
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.07
Grand average of hydropathy-0.088
Instability index48.12
Isoelectric point6.43
Molecular weight180620.91
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01018
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     255.00|      87|     102|    1239|    1338|       1
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 1173- 1228 (81.19/47.92)	.....................................AYFYGHL................PGKL.IVRILN..VLDISKIPFS.....ESFPQQISSPNPAMCPPHDYFTTLLLGIV
 1239- 1338 (122.90/113.47)	SKSGSIGDsSNGAQRtsqSKPpavSQSGPANASESQKAFYQIQD................PGTY.TQLVLETaVVEILSLPVSasqivQSLVQIVVNIQPTLVQSNDSFNGSSNGVG
 1346- 1410 (50.91/26.32)	SPSGGSTD.SIGASR...STP...STSGVNTTNFASRSGYTCQQlsclliqacglllaqlPSDFhSQLYLET.............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.17|      34|     102|      69|     109|       2
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   69-  103 (56.24/32.42)	LPPPNEQFIVDFEQLQSQFPDHEQLRSVtEAILIP
  172-  202 (54.59/26.78)	LPPPST..IANSSNFQSSNP.ASPLTSV.HTIGSP
  215-  239 (31.34/10.29)	LSPVKSSDISSAGQ.QSKQRGSPSVR.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.53|      62|     710|     837|     905|       5
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  837-  905 (95.44/83.67)	DFF..LVKREGK.GPTEFSeTLNRVTVvtLAILiktrGIADADHLPYLQNMLEQI...MATSVHTWSEKTLRYFP
 1547- 1614 (95.09/63.52)	DFLhhVIHYEGQgGPVQAS.SKPRPDV..LALI....GRAAESLRPDIQHLLSHLntdVNSSVYAASHPKLVPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.35|      17|     122|     122|     149|       7
---------------------------------------------------------------------------
  122-  141 (29.80/17.64)	LRSLCgigCINWDTFLPALV
  248-  264 (27.43/ 7.61)	LRQLC...CKIILTGLEFSL
  277-  284 (10.11/ 6.76)	LNWL.....VNWD.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.40|      13|     122|     699|     714|       8
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  699-  711 (22.81/20.30)	REVNPLPMSLISG
  719-  731 (22.59/ 8.62)	KLSYQMEDSLFSG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.36|      19|     110|     546|     565|       9
---------------------------------------------------------------------------
  546-  565 (28.49/23.56)	VTWLLAQIIrIELVMTALNS
  659-  677 (35.87/24.56)	VTYTMAQPA.LETVMNWLTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.78|      12|      15|    1045|    1057|      12
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 1045- 1057 (15.32/13.64)	LDIlLLALTDRDD
 1062- 1073 (19.46/11.81)	LRI.VISLLDRQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.20|      23|     783|     630|     657|      13
---------------------------------------------------------------------------
  630-  657 (42.17/33.07)	DEWW.....RQASKGDRMMDYMNMDERsigmfW
 1416- 1443 (38.04/19.28)	ENWWltdvkRSLAEIDSAVGYALLDPT.....W
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01018 with Med23 domain of Kingdom Viridiplantae
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