<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01018

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMDQSQNQRSITTTTSQSRSLQFHPARVPILDLFNLYLGLGRNSRNKPDDSIREPPNKTQKRVHAINRELPPPNEQFIVDFEQLQSQFPDHEQLRSVTEAILIPLVVQCSGHGPRSDFLLFVLRSLCGIGCINWDTFLPALVSSVSSAEIPVGQTSQAVSTVTSSSLSQSGMLPPPSTIANSSNFQSSNPASPLTSVHTIGSPAQSSIEPLSCAALSPVKSSDISSAGQQSKQRGSPSVRNNDISYSSLRQLCCKIILTGLEFSLKPMTYAEIFNHMLNWLVNWDQGQQGVDESDNQKSWRPDNALVAWLHSCLDVIWLLVDEGKCRVPFYELLRSDLQFMENIPDDEALFTLILEIHRRRDMMAMHMQMLDQHLHCPTFGTHRILNQTTPTISGEGIAHLRLSPISYLSVLGEPLNGEDIAISIQKGSLDWERAVRCIRHALRTTPSPDWWRRVLVLASPYRPSAQGPTAGAVFSTEMICEATIDRIVELLKLTNSEINCWQEWLVFSDIFYFLMKSGCINFVDFVDKLVSRLAEGDHHTLKTNHVTWLLAQIIRIELVMTALNSDSRKVETTRKVLSFHREDRSSDPNSPQSILLDFVSSCQNLRIWSLNTSAREYLNNEQLQKGKQIDEWWRQASKGDRMMDYMNMDERSIGMFWVVTYTMAQPALETVMNWLTSAGVIDLAPATNLQPPERLVCTREVNPLPMSLISGFSMNLCLKLSYQMEDSLFSGQVLPSIAMVETYTRLLLIAPHSLFRSHFIHLGQKSPSLLSRPGVTLLVLEILNYRLLPLYRYQGKSKALMYDVTKIISALKGKRGDHRVFRLAENLCLNLIFSLRDFFLVKREGKGPTEFSETLNRVTVVTLAILIKTRGIADADHLPYLQNMLEQIMATSVHTWSEKTLRYFPSVLREALSGRPDKRSLAIQTWQQAEQTVIHQCNQLLSPSADSNYVMTYINHSFPQHRQYLCAGALILMQGHAENINSGNLGRVLREFSPEEVTSNIYTMVDVMLHHMQIELQQGHLIQDLMLKAISSLAFFVWTNEILPLDILLLALTDRDDDPHALRIVISLLDRQELQQRVKLFCLTRGHPEHWLYTGMFKRVELQKALGNHLSWKDRQPVYFDDIAARLLPIIPLIIYRLIENDAMDTAERLLALYSPLLAYYPLRFTFVRDILAYFYGHLPGKLIVRILNVLDISKIPFSESFPQQISSPNPAMCPPHDYFTTLLLGIVNNVIPPLHNNSKSGSIGDSSNGAQRTSQSKPPAVSQSGPANASESQKAFYQIQDPGTYTQLVLETAVVEILSLPVSASQIVQSLVQIVVNIQPTLVQSNDSFNGSSNGVGQGSVLPTSPSGGSTDSIGASRSTPSTSGVNTTNFASRSGYTCQQLSCLLIQACGLLLAQLPSDFHSQLYLETTRIIKENWWLTDVKRSLAEIDSAVGYALLDPTWAAQDNTSTAIGNVVALLHSFFSNLPQEWLEGTNVIIKQLRPVTSVAMLRIAFRIMSPLLPKLANAHALFNKTLSILLSVLVDVFGKNSQTSTAVDASEIADIIDFLHHVIHYEGQGGPVQASSKPRPDVLALIGRAAESLRPDIQHLLSHLNTDVNSSVYAASHPKLVPNPT
Length1615
PositionTail
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.07
Grand average of hydropathy-0.088
Instability index48.12
Isoelectric point6.43
Molecular weight180620.91
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01018
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     255.00|      87|     102|    1239|    1338|       1
---------------------------------------------------------------------------
 1173- 1228 (81.19/47.92)	.....................................AYFYGHL................PGKL.IVRILN..VLDISKIPFS.....ESFPQQISSPNPAMCPPHDYFTTLLLGIV
 1239- 1338 (122.90/113.47)	SKSGSIGDsSNGAQRtsqSKPpavSQSGPANASESQKAFYQIQD................PGTY.TQLVLETaVVEILSLPVSasqivQSLVQIVVNIQPTLVQSNDSFNGSSNGVG
 1346- 1410 (50.91/26.32)	SPSGGSTD.SIGASR...STP...STSGVNTTNFASRSGYTCQQlsclliqacglllaqlPSDFhSQLYLET.............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.17|      34|     102|      69|     109|       2
---------------------------------------------------------------------------
   69-  103 (56.24/32.42)	LPPPNEQFIVDFEQLQSQFPDHEQLRSVtEAILIP
  172-  202 (54.59/26.78)	LPPPST..IANSSNFQSSNP.ASPLTSV.HTIGSP
  215-  239 (31.34/10.29)	LSPVKSSDISSAGQ.QSKQRGSPSVR.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.53|      62|     710|     837|     905|       5
---------------------------------------------------------------------------
  837-  905 (95.44/83.67)	DFF..LVKREGK.GPTEFSeTLNRVTVvtLAILiktrGIADADHLPYLQNMLEQI...MATSVHTWSEKTLRYFP
 1547- 1614 (95.09/63.52)	DFLhhVIHYEGQgGPVQAS.SKPRPDV..LALI....GRAAESLRPDIQHLLSHLntdVNSSVYAASHPKLVPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.35|      17|     122|     122|     149|       7
---------------------------------------------------------------------------
  122-  141 (29.80/17.64)	LRSLCgigCINWDTFLPALV
  248-  264 (27.43/ 7.61)	LRQLC...CKIILTGLEFSL
  277-  284 (10.11/ 6.76)	LNWL.....VNWD.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.40|      13|     122|     699|     714|       8
---------------------------------------------------------------------------
  699-  711 (22.81/20.30)	REVNPLPMSLISG
  719-  731 (22.59/ 8.62)	KLSYQMEDSLFSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.36|      19|     110|     546|     565|       9
---------------------------------------------------------------------------
  546-  565 (28.49/23.56)	VTWLLAQIIrIELVMTALNS
  659-  677 (35.87/24.56)	VTYTMAQPA.LETVMNWLTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.78|      12|      15|    1045|    1057|      12
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 1045- 1057 (15.32/13.64)	LDIlLLALTDRDD
 1062- 1073 (19.46/11.81)	LRI.VISLLDRQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.20|      23|     783|     630|     657|      13
---------------------------------------------------------------------------
  630-  657 (42.17/33.07)	DEWW.....RQASKGDRMMDYMNMDERsigmfW
 1416- 1443 (38.04/19.28)	ENWWltdvkRSLAEIDSAVGYALLDPT.....W
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01018 with Med23 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SKSGSIGDSSNGAQRTSQSKPPAVSQSGPAN
2) SNGVGQGSVLPTSPSGGSTDSIGASRSTPST
1239
1334
1269
1364










Molecular Recognition Features






MoRF SequenceStartStop




1) LDLFNLYLGLGR
30
41