<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01017

Description Mediator of RNA polymerase II transcription subunit 33A
SequenceMTTAVVWERVIEITKCGRSTEVWSIEVTSWLKTAGVLLPSVELAHRLVSHICWDNNVAVTWKYLEKAMESRMVPPFLVLALLSTKVVPNRHPLLHPPAYSLYLHLLNTHAFSLSSLINSPNYPSLMNSIHQLLRLSQLYHDSSSYPPPPPPPHPGVVLVQFLFTLVWQLLQASLQDEALLQHKNSLLFLDHPDLTMELDNHHHHPLHAKNTATAIQFIAHFLHNKLTSRILSLVQRNMSTHWGAFVDDLEQLAANSLILRSLKHDVSPELFYPLNLKLNWPLSCESNKKMKLSSVLCASGSGSADQSHNDSSLWLPIDLILEDAMDGHHHVMAASAVELLTDLVKALQAVNATAWHNAFLGLWFAALRLVQRERDPSEGPVPRLDTCLCMLLCITTLVVANLIEEEEGELIEEAERSPRNQRKDKLAMGKRRGELVASLQLLGDYEDLLNPPQPVTWVANQAAAKATMFVSGHSGYLEYMNVNDLPTNCSGNLRHLIVEACIARHLIDTSAYFWPGYVSAPSNQLPRGIPNHLPSWSSLMKGSLLNPPWVNVLVATPASSLAEIEKIFEFAINGSDEEKISAATILCGASLVRGWNVQEHVVFFIIKLLSPAVPPKYAGTENHLISYAPFLNVLLIGISSVDSVQIFSLHGAVPLLAAALMPICEAFGSCVPSVSWTAATGEKLSCHVVFSNAFVLLLRLWQFNHPPVEHVMGGAATPALGSQLGPEYLLLVRNSTLASFGKSPRDRIKSRRFSKMISFSTEPVFMDSFPKLNTWYQQHQECLASTRCALVPGGPILRIVDALLSMMCRKINRSAQSLTSTTSGSSNSSGSSLDDALMKLKVPAWDILEAAPFVLDAALTACAHGRLSPRELATGLKDIADFLPASLATIVSYLSAEVTRGVWKPAFMNGTDWPSPAANLSIVEQQIKKILAATGVDVPSLAIDGNAPATLPLPLAAFLSLTITYKLDKSSERFLVLIGPSMINLSAGCPWPCMPIVGSLWAQKVKRWSDFFVFSASRTVFHHSRDAVVQLLKSCFTSTLGLGSACIYNNGGVGALLGHGFGSHFLGGISPVAPGILYLRVYRSIRDAMFLTEEIVSLLMLSVRDIASGGLPNGEAHKPKMTKYGMRYGQVSLAASMTRVKHAALLGASFLWISGGSSLIQSLITETLPSWFLSAPGLEQEVGESGVVVAILRGYALACFAVLSGTFAWGIDSLSAASKRRPKIIGIHLEFLANALDGKISLRCDCATWRAYVSGFMSLMVSCTPLWIEELDVDMLKRVSKGLRQMNEDGLALQLLEIRGKSLMGEVAEMIIQNEL
Length1316
PositionTail
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.08
Grand average of hydropathy0.196
Instability index46.21
Isoelectric point6.84
Molecular weight143983.42
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01017
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.02|      15|      89|     526|     540|       1
---------------------------------------------------------------------------
  526-  540 (31.09/18.84)	PR..GIPNHLPSWSSLM
  615-  631 (23.93/12.59)	PKyaGTENHLISYAPFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.17|      53|     353|     324|     383|       2
---------------------------------------------------------------------------
  330-  383 (87.18/63.43)	HVMAASAVELLTDLVK....ALQAVNATAWHNAfLGLWFAA..LRLVQRERDPSEGPVPR
  687-  745 (81.99/42.58)	HVVFSNAFVLLLRLWQfnhpPVEHVMGGAATPA.LGSQLGPeyLLLVRNSTLASFGKSPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.64|      71|     788|     424|     496|       5
---------------------------------------------------------------------------
  424-  496 (116.06/80.60)	DKL.AMGKRRGELVA.SLQLLGDYED..LLNPPQPVTWVANqAAAKATMFVSGHSGYLEYMNVNDLPTNCSGnLRHL
 1212- 1286 (111.58/68.90)	DSLsAASKRRPKIIGiHLEFLANALDgkISLRCDCATWRAY.VSGFMSLMVSCTPLWIEELDVDMLKRVSKG.LRQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.65|      29|     104|    1042|    1075|       6
---------------------------------------------------------------------------
 1042- 1075 (50.05/36.62)	LGSACIYNNGG...VGALLGHGFGSHFLGgispvAPG
 1146- 1177 (49.60/25.88)	LGASFLWISGGsslIQSLITETLPSWFLS.....APG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     466.73|     140|     676|     173|     317|       7
---------------------------------------------------------------------------
  102-  148 (39.65/16.27)	...................................................YLH.LLNTHAFSLSSLINSPN.Y.PSLMN..SIHQL.....LR..............LSQLYHDSSS...YPPP..............................................
  173-  317 (232.31/161.02)	SLqDEALLQHK.NSLLFLDHPDLTME..LDNHHHHPLHAKNTATAIQFIAHFLHNKLTSRILSLVQRNMSTH.W.GAFVD..DLEQLAAN.SLI..............LRSLKHDVSPELFYPLNLklNWPLSCESNKKMKLSS..VLCASGSGSADQShnDSSLW..LPI
  832-  996 (194.77/120.60)	SL.DDALMKLKvPAWDILEAAPFVLDaaLTACAHGRLSPRELATGLKDIADFLPASLAT.IVSYLSAEVTRGvWkPAFMNgtDWPSPAANlSIVeqqikkilaatgvdVPSLAIDGNAPATLPLPL..AAFLSLTITYKLDKSSerFLVLIGPSMINLS..AGCPWpcMPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01017 with Med33 domain of Kingdom Viridiplantae
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