<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP01006

Description Mediator complex subunit 25 von willebrand factor type A protein
SequenceMENKRWLNIVVDGNKALEKYWTDILSNYLEKIVRCFVGESQEQESYLGLVLYNANSELVEAGYDMQFINWTKDVNKFMENLSHLSFNGNDANQSTMAEGLAEALVMYPKPCDTMTEREYYISERHCILVAPGDPAPKSMLVCLPMIQRAQVIGQRLKACQADFLEVAKTCIPLSVSLSVITPNPVPIFGAIFNMGNNALTLSNAPISSYSTGQLTVLLSKNFREAHVALKEKGIMEYPSTTSVGSISAAPDTTLFRAFSTNLQEEQVSSSMAIGDTIRETDNTITPEPVSTSQHNSQENIVQMNLYEDIMSELDDDDLFTPNKRSKTFAPLEDDPDLQDFFKFDQNPFEGFDQFIKQDQQVFNQQEIPTEEAVFNQQQIPTEEAGVDFANELQEILNGASRNTSTAQTANVECTTSSFQEVNKYVAPASNVGEGSSTGLLHESNLQSWYNPHAMTSTSKLDSQSFPTNAFNGNMTSTSTLDSRSFSTNNFNGNFTLSNVMGNSQMQQLQPGSSQNQFSMSPGFARGQVGNFSVQPMGQHFQACNQFLRNNNTASYNLPAFGANTWLRPMPSLSPSYPSASMCFPTLKEIQDYVQTWEGTLAGKITSSRITILRAKAFRKSSTPPTLTLDWPGRLEISNYLPQKALLHTRRFSQPIHYLFFHVAKYSNVDLYNHCKTRNNCAKVDLQFQTIILSPTEREPLFVGTVFPGVSIIF
Length713
PositionUnknown
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.10
Grand average of hydropathy-0.372
Instability index45.20
Isoelectric point4.98
Molecular weight79612.36
Publications
PubMed=22089132
PubMed=24767513

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP01006
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.59|      17|      17|     457|     473|       1
---------------------------------------------------------------------------
  457-  473 (34.21/19.43)	TSKLDSQSFPTNAFNGN
  477-  493 (34.38/19.56)	TSTLDSRSFSTNNFNGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.99|      15|      17|     544|     558|       2
---------------------------------------------------------------------------
  544-  558 (27.41/15.37)	NQFLRNNNTASYNLP
  563-  577 (30.58/17.99)	NTWLRPMPSLSPSYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.03|      15|      19|     256|     270|       3
---------------------------------------------------------------------------
  256-  270 (24.27/11.95)	RAFSTNLQEEQVSSS
  278-  292 (25.77/13.06)	RETDNTITPEPVSTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.01|      15|      19|     402|     420|       4
---------------------------------------------------------------------------
  402-  416 (25.43/23.21)	NTSTAQTANVECTTS
  422-  436 (25.58/10.96)	NKYVAPASNVGEGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.32|      27|     381|     131|     159|       6
---------------------------------------------------------------------------
  131-  159 (45.90/38.18)	PGDPAPKSMLVclPMIQRAQV.......IGQRLKAC
  510-  543 (46.42/30.77)	PGSSQNQFSMS..PGFARGQVgnfsvqpMGQHFQAC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP01006 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QEIPTEEAVFNQQQIPTEEAGVDFANELQEILNGASRNTSTAQTANVE
2) SSMAIGDTIRETDNTITPEPVSTSQHNSQE
365
269
412
298










Molecular Recognition Features






MoRF SequenceStartStop




1) DLQDFFKFDQ
336
345