<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00995

Description Mediator complex subunit 25 von willebrand factor type A protein
SequenceMENKRWLNIVVDGNKALEQYWHDILSNYLEKIVRCFVGESQEQESYLGLVLYNANSELVEAGYDMQFINWTKDVTKFMENLSHLSFNGNDANQSTMAEGLAEALVMYPKPCDTMTEREYYISERHCILVAPGDPAPKSMLVCLPMIQRAQVIGQRLKACQADFLEVAKTCIPLSVSLSVITPNPVPIFGAIFNMGNNALTLSNAPISSYSTGQLTVLMSKNFREAHIALKEKGIMEYPSTTSVGSISAAPDTTLLRAFSTNFQEEQVSSSMAIGDRIHETGNAITPEPVSTSQHNSQELVVSKATDQENIVQMNLYEDIMSELDSDDDLFKPNKRSKTFAPLEDDADLQDFFKFDQNTFFDGFDQFLEQQDQQVMNQQQIPTEEAGVDFAKELQEILNGASRNTSTAQTANVECTTSSFQEVNVQPEELRAPAPNAGEGSSTGLLHESNLQLWYNPHAMTSTSTLDSQSFPTNAFNGNMTSISTLDSQSSQTNNFNRNMTSTSTLDSQSFPTNAFNGNFTFSNVMANSQMQQPQPVSSQNQFSGFPGFARGQIGNFSGQPVGQTGNFSGQPVGQHFQAYNHFLRNNNTAAYNLPAFGANTWLRPMQSLSPSYPSARMHFPTLEEIQDYVQTWEGTLAGKITSSRTTILRAKAFKKSSTPPTLTLGWPGRLEISNYLPQKALLHTRRFSQPIHYLFFHVAKYGNVDLYNHCKTRNNCAKVDLQFQTIILSPTEREPLFVGTVFPGVSIIFQSF
Length752
PositionUnknown
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.10
Grand average of hydropathy-0.398
Instability index47.52
Isoelectric point5.05
Molecular weight83756.65
Publications
PubMed=22089132
PubMed=24767513

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00995
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.33|      11|      18|     459|     469|       1
---------------------------------------------------------------------------
  459-  469 (24.04/12.72)	MTSTSTLDSQS
  479-  489 (23.25/12.10)	MTSISTLDSQS
  499-  509 (24.04/12.72)	MTSTSTLDSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.91|      33|      35|     510|     542|       2
---------------------------------------------------------------------------
  510-  536 (46.94/24.14)	....................FPTNAFN..GNFTFSNVMANSQMQQPQPV
  537-  561 (30.55/13.11)	SSQNQF............sgFPGFARGqiGNFS............GQPV
  562-  608 (45.42/23.12)	GQTGNFsgqpvgqhfqaynhFLRNNNT..AAYNLPAFGANTWLRPMQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.99|      26|      37|     202|     227|       3
---------------------------------------------------------------------------
  202-  227 (45.14/31.09)	SNAPISSYSTGQLTVLM...SKNFREAHI
  239-  267 (37.85/24.81)	STTSVGSISAAPDTTLLrafSTNFQEEQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.98|      15|      41|     124|     144|       4
---------------------------------------------------------------------------
  124-  144 (24.27/25.81)	RHCIlvapgdPAPKSMLVCLP
  168-  182 (26.71/14.06)	KTCI......PLSVSLSVITP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.23|      18|      18|     312|     329|       9
---------------------------------------------------------------------------
  312-  329 (30.82/24.89)	QMNLYEDIMSELDSDDDL
  331-  348 (30.41/24.45)	KPNKRSKTFAPLEDDADL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00995 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QDQQVMNQQQIPTEEAGVDFAKELQEILNGASRNTSTAQTANVECTTSSFQEVNVQPEELRAPAPNAGEGSSTGLLHES
2) SSMAIGDRIHETGNAITPEPVSTSQHNSQELVVSK
3) STSTLDSQSFPTNAFNGNMTSISTLDSQSSQTNNFNRNMTSTSTLDSQS
370
269
461
448
303
509










Molecular Recognition Features






MoRF SequenceStartStop




1) FAPLE
2) LQDFFK
339
348
343
353