<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00990

Description Mediator of RNA polymerase II transcription subunit 33A
SequenceMAMAVPAQTIAGYDRFPWDAILLQTNSALMNNTDPNVWASQIISTLRSTAVTLPSVDLAHRLVSHLFWNHHSPIAWKLLDIAASLNLLPPLLLVALLSTRIVPMRKVYPQAYRLYLELVKQYVLMLQFRNNSPNYEMIMESIDNVLQLSQVYSHKVCEPGVALVEFVFSILWQLLEAILDDEGLLDHVPENKPRWLSRSHDMDIAEHDCINEMKTEQKEGMQRKNTMIAIEIIVQLLQNKMTSRLLCLVHRNMPSYWGSFNHQMQLIASKSSILKNLKHITADTLLSLMENIHGVVSCNTKSKLESNVVIPAGSQIAFGGQCEGSSWSSIWLPIDLILEDALDGGHVAALSAIEIITDLVKSLHAVNGTMWHNTFLGLWIAALRLVQRERNLSEGPVPRLDTCMCILLSITTNVVANIIEEEEGELIEEAECGPTNQGKNQQVLGKRRGELITCLQSLGDFQCLLTPPQAVLREANQAAAKAMPIMLVSGNPVGSGHSKSSSMDDLPMNCFGNLRHLIVEACIARNILDTSAYFWPGYVNACSNQIPSSISNQVDGWSSLMKGSKLTPGLVDVLAATPASSLAEIEKVYEITIDGSDEEKISAATILCGASLASGWNIQEHTIIFITKLLSPICLPNHTGTENHLISQARFLNVLLVGISSADCVHIFSLHGLVPLLAAGLMQICEVFGSCVYDVSWTVATGGKLSPQEVFSNAFTLLLRFWRFDHLSIEQVRGNAATPPLGNLFSPENLLLVRNSRVASFGRSTKDSLKLKRLSKIVRFPKESIYIDSFPKLNFWHRQHQERIASTHSGLMPGGPVQQIVDALLRMMFRKVNVGFEPSTPTTLGSISSSRFGSALDDALVKLKVPAWDILEAVPFVLDASLNACAYGTVSTRELATGLKRLADFIPASLVAIASYFSAEVTRGIWKPVFMNGTDWPSPAANLSLVEQHIKKILAATGVDVPSLAIDEEYPATLPLPLAAFVSLSITYKLDKGKGRFLLLIGPTLNAVASVCVWPCMPILTSLWIQKVKRWRDYFLLRASGTVFHHNKDAVVQLLKSCFTSTLGLGSTCMNNNGGVGALLGHGLASHSPVAPGILYLRVYRFIGDIMFLNKAIMSILLLSVRDIASSDELPKGDVKKQLNKIKYGMKRGQVSLVRYMARVKQAALLGASLVWISGGQKLVQSLIRGTVPSWFLSADTLEQEDGETGVLVAMLSGYALAYFVMLSVAFAWGIDHSSVPPNRRAKVIAIHLDFLADTMERFTTLSCHHATWQAYVSGFVSLIVCCTPMWIREVDAELLKRLSKGLRQLNEDELALRLLEIGGIGVMGTAAEMIIESARML
Length1338
PositionTail
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.07
Grand average of hydropathy0.201
Instability index42.55
Isoelectric point6.94
Molecular weight147190.62
Publications
PubMed=22089132
PubMed=24767513

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00990
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.50|      18|      23|     921|     938|       1
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  921-  938 (36.95/23.12)	VTRGIWKPVFMNGTDWPS
  946-  963 (30.54/17.89)	VEQHIKKILAATGVDVPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.11|      84|     237|     248|     354|       2
---------------------------------------------------------------------------
  248-  354 (123.54/129.32)	LVHRNmPSYWGsfnhqmqliASKSS........ILKNLKHitadtllsLMenihgVVSCNTKSKLESNV......VIPAGSQIAFGGQCEGSSWSSIWLPIDLI..LEDALDGGHVAALSAIE
  487-  586 (126.57/82.62)	LVSGN.PVGSG.........HSKSSsmddlpmnCFGNLRH........LI.....VEACIARNILDTSAyfwpgyVNACSNQIPSSISNQVDGWSSLMKGSKLTpgLVDVLAATPASSLAEIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.40|      11|     234|     978|     988|       3
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  978-  988 (19.19/12.52)	LAAFVSLSITY
 1217- 1227 (20.21/13.60)	LAYFVMLSVAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      14|     260|    1021|    1038|       5
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 1021- 1038 (20.98/19.08)	TSLWIQKVkrwrDYFLLR
 1284- 1297 (26.72/12.78)	TPMWIREV....DAELLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.86|      57|     103|     637|     739|       6
---------------------------------------------------------------------------
  637-  726 (72.31/106.51)	NHTGTENHLIsqARFLNVLLVGISSADCVHIFSLHGLVpllaaglmqicevfgscvydvswtvatggKLsPQE.VFSNAFTlLLRFWRFDH
  743-  800 (95.55/45.01)	NLFSPENLLL..VRNSRVASFGRSTKDSLKLKRLSKIV.............................RF.PKEsIYIDSFP.KLNFWHRQH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.73|      13|     817|     233|     245|       7
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  233-  245 (22.69/14.41)	IVQLLQNKMTSRL
 1051- 1063 (23.04/14.75)	VVQLLKSCFTSTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.38|      26|     235|     146|     193|      10
---------------------------------------------------------------------------
  153-  179 (41.68/55.79)	SHKVCEPGV...ALVEFVFSILWqLLEAIL
 1086- 1114 (42.70/11.71)	SHSPVAPGIlylRVYRFIGDIMF.LNKAIM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00990 with Med33 domain of Kingdom Viridiplantae
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