<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00990

Description Mediator of RNA polymerase II transcription subunit 33A
SequenceMAMAVPAQTIAGYDRFPWDAILLQTNSALMNNTDPNVWASQIISTLRSTAVTLPSVDLAHRLVSHLFWNHHSPIAWKLLDIAASLNLLPPLLLVALLSTRIVPMRKVYPQAYRLYLELVKQYVLMLQFRNNSPNYEMIMESIDNVLQLSQVYSHKVCEPGVALVEFVFSILWQLLEAILDDEGLLDHVPENKPRWLSRSHDMDIAEHDCINEMKTEQKEGMQRKNTMIAIEIIVQLLQNKMTSRLLCLVHRNMPSYWGSFNHQMQLIASKSSILKNLKHITADTLLSLMENIHGVVSCNTKSKLESNVVIPAGSQIAFGGQCEGSSWSSIWLPIDLILEDALDGGHVAALSAIEIITDLVKSLHAVNGTMWHNTFLGLWIAALRLVQRERNLSEGPVPRLDTCMCILLSITTNVVANIIEEEEGELIEEAECGPTNQGKNQQVLGKRRGELITCLQSLGDFQCLLTPPQAVLREANQAAAKAMPIMLVSGNPVGSGHSKSSSMDDLPMNCFGNLRHLIVEACIARNILDTSAYFWPGYVNACSNQIPSSISNQVDGWSSLMKGSKLTPGLVDVLAATPASSLAEIEKVYEITIDGSDEEKISAATILCGASLASGWNIQEHTIIFITKLLSPICLPNHTGTENHLISQARFLNVLLVGISSADCVHIFSLHGLVPLLAAGLMQICEVFGSCVYDVSWTVATGGKLSPQEVFSNAFTLLLRFWRFDHLSIEQVRGNAATPPLGNLFSPENLLLVRNSRVASFGRSTKDSLKLKRLSKIVRFPKESIYIDSFPKLNFWHRQHQERIASTHSGLMPGGPVQQIVDALLRMMFRKVNVGFEPSTPTTLGSISSSRFGSALDDALVKLKVPAWDILEAVPFVLDASLNACAYGTVSTRELATGLKRLADFIPASLVAIASYFSAEVTRGIWKPVFMNGTDWPSPAANLSLVEQHIKKILAATGVDVPSLAIDEEYPATLPLPLAAFVSLSITYKLDKGKGRFLLLIGPTLNAVASVCVWPCMPILTSLWIQKVKRWRDYFLLRASGTVFHHNKDAVVQLLKSCFTSTLGLGSTCMNNNGGVGALLGHGLASHSPVAPGILYLRVYRFIGDIMFLNKAIMSILLLSVRDIASSDELPKGDVKKQLNKIKYGMKRGQVSLVRYMARVKQAALLGASLVWISGGQKLVQSLIRGTVPSWFLSADTLEQEDGETGVLVAMLSGYALAYFVMLSVAFAWGIDHSSVPPNRRAKVIAIHLDFLADTMERFTTLSCHHATWQAYVSGFVSLIVCCTPMWIREVDAELLKRLSKGLRQLNEDELALRLLEIGGIGVMGTAAEMIIESARML
Length1338
PositionTail
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.07
Grand average of hydropathy0.201
Instability index42.55
Isoelectric point6.94
Molecular weight147190.62
Publications
PubMed=22089132
PubMed=24767513

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00990
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.50|      18|      23|     921|     938|       1
---------------------------------------------------------------------------
  921-  938 (36.95/23.12)	VTRGIWKPVFMNGTDWPS
  946-  963 (30.54/17.89)	VEQHIKKILAATGVDVPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.11|      84|     237|     248|     354|       2
---------------------------------------------------------------------------
  248-  354 (123.54/129.32)	LVHRNmPSYWGsfnhqmqliASKSS........ILKNLKHitadtllsLMenihgVVSCNTKSKLESNV......VIPAGSQIAFGGQCEGSSWSSIWLPIDLI..LEDALDGGHVAALSAIE
  487-  586 (126.57/82.62)	LVSGN.PVGSG.........HSKSSsmddlpmnCFGNLRH........LI.....VEACIARNILDTSAyfwpgyVNACSNQIPSSISNQVDGWSSLMKGSKLTpgLVDVLAATPASSLAEIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.40|      11|     234|     978|     988|       3
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  978-  988 (19.19/12.52)	LAAFVSLSITY
 1217- 1227 (20.21/13.60)	LAYFVMLSVAF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      14|     260|    1021|    1038|       5
---------------------------------------------------------------------------
 1021- 1038 (20.98/19.08)	TSLWIQKVkrwrDYFLLR
 1284- 1297 (26.72/12.78)	TPMWIREV....DAELLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.86|      57|     103|     637|     739|       6
---------------------------------------------------------------------------
  637-  726 (72.31/106.51)	NHTGTENHLIsqARFLNVLLVGISSADCVHIFSLHGLVpllaaglmqicevfgscvydvswtvatggKLsPQE.VFSNAFTlLLRFWRFDH
  743-  800 (95.55/45.01)	NLFSPENLLL..VRNSRVASFGRSTKDSLKLKRLSKIV.............................RF.PKEsIYIDSFP.KLNFWHRQH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.73|      13|     817|     233|     245|       7
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  233-  245 (22.69/14.41)	IVQLLQNKMTSRL
 1051- 1063 (23.04/14.75)	VVQLLKSCFTSTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.38|      26|     235|     146|     193|      10
---------------------------------------------------------------------------
  153-  179 (41.68/55.79)	SHKVCEPGV...ALVEFVFSILWqLLEAIL
 1086- 1114 (42.70/11.71)	SHSPVAPGIlylRVYRFIGDIMF.LNKAIM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00990 with Med33 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA