<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00979

Description Heat shock 70 kDa protein
SequenceMMAGSWKRGSLFVLAIISIGCLFACSNAKEEATKLGTVIGIDLGTTYSCVGVYKNGHVEIIANDQGNRITPSWVSFTDDERLIGEAAKNLAAVNPERTIFDVKRLIGRKFEDKEVQRDMKLVPYKIVNRDGKPYIQVRVKDGETKVFSPEEISAMILGKMKETAEGFLGKTIRDAVVTVPAYFNDAQRQATKDAGVIAGLNVARIINEPTAAAIAYGLDKKGGEKNILVFDLGGGTFDVSILTIDNGVFEVLATNGDTHLGGEDFDQRIMEYFIKLIKKKHSKDISKDNRALGKLRRESERAKRALSSQHQVRVEIESLFDGVDFSEPLTRARFEELNNDLFRKTMGPVKKAMDDAGLQKNQIDEIVLVGGSTRIPKVQQLLKDYFDGKEPNKGVNPDEAVAFGAAVQGSILSGEGGVETKDILLLDVAPLTLGIETVGGVMTKLIPRNTVIPTKKSQVFTTYQDQQTTVSIQVFEGERSLTKDCRLLGKFDLSGIPPAPRGTPQIEVTFEVDANGILNVKAEDKGTGKSEKITITNEKGRLSQEEIERMVREAEEFAEEDKKVKERIDARNALETYVYNMKNQVSDKDKLADKLESDEKEKIETAVKEALEWLDDNQSVEKEEYEEKLKEVEAVCNPIITAVYQRSGGAPGGGASGEDEEDESHDEL
Length668
PositionUnknown
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.06
Grand average of hydropathy-0.438
Instability index30.81
Isoelectric point5.08
Molecular weight73697.63
Publications
PubMed=22089132
PubMed=24767513

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IBA:GO_Central
endoplasmic reticulum chaperone complex	GO:0034663	IBA:GO_Central
endoplasmic reticulum lumen	GO:0005788	IBA:GO_Central
membrane	GO:0016020	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IBA:GO_Central
ATPase activity	GO:0016887	IBA:GO_Central
heat shock protein binding	GO:0031072	IBA:GO_Central
misfolded protein binding	GO:0051787	IBA:GO_Central
protein folding chaperone	GO:0044183	IBA:GO_Central
unfolded protein binding	GO:0051082	IBA:GO_Central

GO - Biological Process
cellular response to unfolded protein	GO:0034620	IBA:GO_Central
chaperone cofactor-dependent protein refolding	GO:0051085	IBA:GO_Central
endoplasmic reticulum unfolded protein response	GO:0030968	IBA:GO_Central
protein refolding	GO:0042026	IBA:GO_Central
ubiquitin-dependent ERAD pathway	GO:0030433	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00979
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.77|      21|      21|     589|     609|       1
---------------------------------------------------------------------------
  561-  580 (23.08/11.04)	DkKVKERI..DARNALETYVYN
  589-  609 (33.28/18.89)	D.KLADKLESDEKEKIETAVKE
  615-  631 (20.41/ 8.99)	.....DDNQSVEKEEYEEKLKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.28|      17|      21|      67|      84|       2
---------------------------------------------------------------------------
   67-   84 (28.40/24.53)	N..RITPSWVSFtDDERLIG
   89-  107 (25.88/16.59)	NlaAVNPERTIF.DVKRLIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.92|      15|      21|     416|     430|       3
---------------------------------------------------------------------------
  416-  430 (26.48/16.85)	GGVETKDILLLDVAP
  439-  453 (28.44/18.60)	GGVMTKLIPRNTVIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.30|      11|      27|     232|     242|       4
---------------------------------------------------------------------------
  232-  242 (20.46/ 9.31)	LGGGTFDVSIL
  260-  270 (21.85/10.34)	LGGEDFDQRIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.55|      16|      16|     186|     201|       5
---------------------------------------------------------------------------
  186-  201 (26.64/20.25)	AQRQATKDAGVIA.GLN
  203-  219 (20.92/14.12)	ARIINEPTAAAIAyGLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.52|      15|      18|     317|     332|       7
---------------------------------------------------------------------------
  317-  332 (21.32/17.54)	ESLFDGVdFSE...PLTRA
  335-  352 (20.21/10.92)	EELNNDL.FRKtmgPVKKA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00979 with Med37 domain of Kingdom Viridiplantae
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