<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00972

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMATPGMGMLDGGVPTAQPPGTDMTGICFRDQLWLNTYPLDRNLVFDYFALSPFYDWTSNNEQLRMRSHHPLDSSQLTKMIGIEYVLSEVMEPHLFIMKKQKRDSPDKVTPMLAYYILDGSIYQAPQLSNVFAARIGRALYYIEKAFTTAASKLEKIGYVDSENETTIPEPKVAKETIDLKEIKRVDHILASLQRKLPPAPPPPPFPEGYVPPSTAETEKGPETQEAAESLAPTVDPILDQGPAKRMKF
Length248
PositionHead
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.09
Grand average of hydropathy-0.412
Instability index57.60
Isoelectric point5.33
Molecular weight27789.56
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00972
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.16|      11|      29|      30|      40|       1
---------------------------------------------------------------------------
   30-   40 (22.36/16.41)	DQLWLNT.YPLD
   61-   72 (16.80/10.55)	EQLRMRShHPLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00972 with Med6 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SLQRKLPPAPPPPPFPEGYVPPSTAETEKGPETQEAAESLAPTVDPILDQGPAKRM
191
246










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRMKF
2) ILASLQ
243
188
248
193